https://covid19.who.int/. Accessed 18 Dec 2020.
2.•Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26:1017–32. https://doi.org/10.1038/s41591-020-0968-3This review highlights the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 in order to help clinicians and scientists in recognizing and monitoring the spectrum of manifestations.
CAS Article PubMed Google Scholar
3.Scudellari M. How Iceland hammered COVID with science. Nature. 2020;587:536–9. https://doi.org/10.1038/d41586-020-03284-3.
CAS Article PubMed Google Scholar
4.Obesity. 2020. https://www.who.int/health-topics/obesity. Accessed 18 Dec 2020.
5.Hales CM, Carroll MD, Fryar CD, Ogden CL. Prevalence of obesity and severe obesity among adults: United States, 2017–2018. 2020. NCHS Data Brief, no 360. Hyattsville, MD: National Center for Health Statistics.
6.Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008;32:1431–7. https://doi.org/10.1038/ijo.2008.102.
7.Wadman M. Why obesity worsens COVID-19. Science. 2020;369:1280–1. https://doi.org/10.1126/science.369.6509.1280.
CAS Article PubMed Google Scholar
8.Hill MA, Sowers JR, Mantzoros CS. Commentary: COVID-19 and obesity pandemics converge into a syndemic requiring urgent and multidisciplinary action. Metabolism. 2020;114:154408. https://doi.org/10.1016/j.metabol.2020.154408.
CAS Article PubMed PubMed Central Google Scholar
9.Obesity and overweight. 2020. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Accessed 18 December 2020.
10.Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6–10. https://doi.org/10.1016/j.metabol.2018.09.005.
CAS Article PubMed Google Scholar
11.Rizzo S, Chawla D, Zalocusky K, Keebler D, Chia J, Lindsay L et al. Descriptive epidemiology of 16,780 hospitalized COVID-19 patients in the United States. 2020:2020.07.17.20156265. 10.1101/2020.07.17.20156265 %J medRxiv. https://doi.org/10.1101/2020.07.17.20156265
12.••Hendren NS, de Lemos JA, Ayers C, Das SR, Rao A, Carter S, et al. Association of Body mass index and age with morbidity and mortality in patients hospitalized with COVID-19: results from the American Heart Association COVID-19 Cardiovascular Disease Registry. Circulation. 2021;143:135–44. https://doi.org/10.1161/circulationaha.120.051936In this American Heart Association’s COVID-19 Cardiovascular Disease Registry, it was shown that patients with obesity are more likely to be hospitalized with COVID-19, and are at higher risk of in-hospital death or mechanical ventilation, in particular, if young (age ≤50 years).
CAS Article PubMed Google Scholar
13.Eastment MC, Berry K, Locke E, Green P, O'Hare A, Crothers K, et al. Body mass index (BMI) and outcomes of SARS-CoV-2 among US veterans. Obesity (Silver Spring). 2020. https://doi.org/10.1002/oby.23111.
14.Maffetone PB, Laursen PB. The Perfect storm: coronavirus (COVID-19) pandemic meets overfat pandemic. Front Public Health. 2020;8:135. https://doi.org/10.3389/fpubh.2020.00135.
Article PubMed PubMed Central Google Scholar
15.Bhasin A, Nam H, Yeh C, Lee J, Liebovitz D, Achenbach C. Is BMI higher in younger patients with COVID-19? Association between BMI and COVID-19 hospitalization by age. Obesity (Silver Spring). 2020;28:1811–4. https://doi.org/10.1002/oby.22947.
16.Kass DA, Duggal P, Cingolani O. Obesity could shift severe COVID-19 disease to younger ages. Lancet. 2020;395:1544–5. https://doi.org/10.1016/s0140-6736(20)31024-2.
CAS Article PubMed PubMed Central Google Scholar
17.Karampela I, Chrysanthopoulou E, Christodoulatos GS, Dalamaga M. Is There an obesity paradox in critical illness? Epidemiologic and metabolic considerations. Curr Obes Rep. 2020;9:231–44. https://doi.org/10.1007/s13679-020-00394-x.
18.Karampela I, Christodoulatos GS, Dalamaga M. The role of adipose tissue and adipokines in sepsis: inflammatory and metabolic considerations, and the obesity paradox. Curr Obes Rep. 2019;8:434–57. https://doi.org/10.1007/s13679-019-00360-2.
19.Burn E, You SC, Sena AG, Kostka K, Abedtash H, Abrahão MTF, et al. An international characterisation of patients hospitalised with COVID-19 and a comparison with those previously hospitalised with influenza. medRxiv. 2020. https://doi.org/10.1101/2020.04.22.20074336.
20.Giannouchos TV, Sussman RA, Mier JM, Poulas K, Farsalinos K. Characteristics and risk factors for COVID-19 diagnosis and adverse outcomes in Mexico: an analysis of 89,756 laboratory-confirmed COVID-19 cases. Eur Respir J. 2020. https://doi.org/10.1183/13993003.02144-2020.
21.Gu T, Mack JA, Salvatore M, Sankar SP, Valley TS, Singh K, et al. COVID-19 outcomes, risk factors and associations by race: a comprehensive analysis using electronic health records data in Michigan Medicine. medRxiv. 2020. https://doi.org/10.1101/2020.06.16.20133140.
22.Reilev M, Kristensen KB, Pottegård A, Lund LC, Hallas J, Ernst MT, et al. Characteristics and predictors of hospitalization and death in the first 11 122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort. Int J Epidemiol. 2020. https://doi.org/10.1093/ije/dyaa140.
23.ICNARC report on COVID-19 in critical care. 2020. https://www.anhinternational.org/resources/documents/icnarc-covid-19-report-2020-07-10/. Accessed 18 December 2020.
24.••Popkin BM, Du S, Green WD, Beck MA, Algaith T, Herbst CH, et al. Individuals with obesity and COVID-19: a global perspective on the epidemiology and biological relationships. Obes Rev. 2020;21:e13128. https://doi.org/10.1111/obr.13128This meta-analysis has shown that obesity increases the risks of infection from SARS-CoV-2, severe infection and hospitalization, admission to the ICU and need of invasive mechanical ventilation as well as the risk of mortality.
CAS Article PubMed Google Scholar
25.Soeroto AY, Soetedjo NN, Purwiga A, Santoso P, Kulsum ID, Suryadinata H, et al. Effect of increased BMI and obesity on the outcome of COVID-19 adult patients: a systematic review and meta-analysis. Diabetes Metab Syndr. 2020;14:1897–904. https://doi.org/10.1016/j.dsx.2020.09.029.
Article PubMed PubMed Central Google Scholar
26.Yang J, Tian C, Chen Y, Zhu C, Chi H, Li J. Obesity aggravates COVID-19: an updated systematic review and meta-analysis. J Med Virol. 2020. https://doi.org/10.1002/jmv.26677.
27.Leong A, Cole J, Brenner LN, Meigs JB, Florez JC, Mercader JM. Cardiometabolic risk factors for COVID-19 susceptibility and severity: a Mendelian randomization analysis. medRxiv. 2020. https://doi.org/10.1101/2020.08.26.20182709.
28.Singh S, Bilal M, Pakhchanian H, Raiker R, Kochhar GS, Thompson CC. Impact of obesity on outcomes of patients with coronavirus disease 2019 in the United States: a multicenter electronic health records network study. Gastroenterology. 2020;159:2221–5.e6. https://doi.org/10.1053/j.gastro.2020.08.028.
CAS Article PubMed Google Scholar
29.Yanover C, Mizrahi B, Kalkstein N, Marcus K, Akiva P, Barer Y, et al. What factors increase the risk of complications in SARS-CoV-2-infected patients? A cohort study in a nationwide Israeli health organization. JMIR Public Health Surveill. 2020;6:e20872. https://doi.org/10.2196/20872.
Article PubMed PubMed Central Google Scholar
30.Petrilli CM, Jones SA, Yang J, Rajagopalan H, O'Donnell L, Chernyak Y, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. Bmj. 2020;369:m1966. https://doi.org/10.1136/bmj.m1966.
Article PubMed PubMed Central Google Scholar
31.••Du Y, Lv Y, Zha W, Zhou N, Hong X. Association of Body mass index (BMI) with critical COVID-19 and in-hospital mortality: a dose-response meta-analysis. Metabolism. 2020:154373. https://doi.org/10.1016/j.metabol.2020.154373This meta-analysis has shown a linear dose-response association between BMI and both COVID-19 severity and mortality.
32.Chu Y, Yang J, Shi J, Zhang P, Wang X. Obesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis. Eur J Med Res. 2020;25:64. https://doi.org/10.1186/s40001-020-00464-9.
CAS Article PubMed PubMed Central Google Scholar
33.Bello-Chavolla OY, Bahena-López JP, Antonio-Villa NE, Vargas-Vázquez A, González-Díaz A, Márquez-Salinas A, et al. Predicting mortality due to SARS-CoV-2: a mechanistic score relating obesity and diabetes to COVID-19 outcomes in Mexico. J Clin Endocrinol Metab. 2020;105. https://doi.org/10.1210/clinem/dgaa346.
34.Kim L, Garg S, O'Halloran A, Whitaker M, Pham H, Anderson EJ, et al. Risk factors for intensive care unit admission and in-hospital mortality among hospitalized adults identified through the U.S. coronavirus disease 2019 (COVID-19)-associated hospitalization surveillance network (COVID-NET). Clin Infect Dis. 2020. https://doi.org/10.1093/cid/ciaa1012.
35.Kaeuffer C, Ruch Y, Fabacher T, Hinschberger O, Mootien J, Eyriey M, et al. The BAS(2)IC score: a useful tool to identify patients at high risk of early progression to severe coronavirus disease 2019. Open Forum Infect Dis. 2020;7:ofaa405. https://doi.org/10.1093/ofid/ofaa405.
CAS Article PubMed PubMed Central Google Scholar
36.Hamadah H, Alahmad B, Behbehani M, Al-Youha S, Almazeedi S, Al-Haddad M, et al. COVID-19 clinical outcomes and nationality: results from a nationwide registry in Kuwait. BMC Public Health. 2020;20:1384. https://doi.org/10.1186/s12889-020-09490-y.
CAS Article PubMed PubMed Central Google Scholar
37.Földi M, Farkas N, Kiss S, Zádori N, Váncsa S, Szakó L, et al. Obesity is a risk factor for developing critical condition in COVID-19 patients: a systematic review and meta-analysis. Obes Rev. 2020;21:e13095. https://doi.org/10.1111/obr.13095.
CAS Article PubMed Google Scholar
38.Malik P, Patel U, Patel K, Martin M, Shah C, Mehta D, et al. Obesity a predictor of outcomes of COVID-19 hospitalized patients-a systematic review and meta-analysis. J Med Virol. 2020. https://doi.org/10.1002/jmv.26555.
39.Hajifathalian K, Kumar S, Newberry C, Shah S, Fortune B, Krisko T, et al. Obesity is associated with worse outcomes in COVID-19: analysis of early data from New York City. Obesity (Silver Spring). 2020;28:1606–12. https://doi.org/10.1002/oby.22923.
40.Goyal P, Choi JJ, Pinheiro LC, Schenck EJ, Chen R, Jabri A, et al. Clinical characteristics of COVID-19 in New York City. N Engl J Med. 2020;382:2372–4. https://doi.org/10.1056/NEJMc2010419.
41.Argenziano MG, Bruce SL, Slater CL, Tiao JR, Baldwin MR, Barr RG, et al. Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series. Bmj. 2020;369:m1996. https://doi.org/10.1136/bmj.m1996.
Article PubMed PubMed Central Google Scholar
42.Baqui P, Bica I, Marra V, Ercole A, van der Schaar M. Ethnic and regional variations in hospital mortality from COVID-19 in Brazil: a cross-sectional observational study. Lancet Glob Health. 2020;8:e1018–e26. https://doi.org/10.1016/s2214-109x(20)30285-0.
Article PubMed PubMed Central Google Scholar
43.Hussain A, Mahawar K, Xia Z, Yang W, El-Hasani S. Obesity and mortality of COVID-19. Meta-analysis. Obes Res Clin Pract. 2020;14:295–300. https://doi.org/10.1016/j.orcp.2020.07.002.
Article PubMed PubMed Central Google Scholar
44.Pranata R, Lim MA, Yonas E, Vania R, Lukito AA, Siswanto BB, et al. Body mass index and outcome in patients with COVID-19: a dose-response meta-analysis. Diabetes Metab. 2020. https://doi.org/10.1016/j.diabet.2020.07.005.
45.Seidu S, Gillies C, Zaccardi F, Kunutsor SK, Hartmann-Boyce J, Yates T, et al. The impact of obesity on severe disease and mortality in people with SARS-CoV-2: a systematic review and meta-analysis. Endocrinol Diabetes Metab. 2020:e00176. https://doi.org/10.1002/edm2.176.
46.Huang Y, Lu Y, Huang YM, Wang M, Ling W, Sui Y, et al. Obesity in patients with COVID-19: a systematic review and meta-analysis. Metabolism. 2020;113:154378. https://doi.org/10.1016/j.metabol.2020.154378.
CAS Article PubMed PubMed Central Google Scholar
47.Földi M, Farkas N, Kiss S, Dembrovszky F, Szakács Z, Balaskó M, et al. Visceral adiposity elevates the risk of critical condition in COVID-19: a systematic review and meta-analysis. Obesity (Silver Spring). 2020. https://doi.org/10.1002/oby.23096.
48.Ho FK, Celis-Morales CA, Gray SR, Katikireddi SV, Niedzwiedz CL, Hastie C, et al. Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. J BMJ Open. 2020;10:e040402. https://doi.org/10.1136/bmjopen-2020-040402.
49.Huizinga GP, Singer BH, Singer K. The collision of meta-inflammation and SARS-CoV-2 pandemic infection. Endocrinology. 2020;161. https://doi.org/10.1210/endocr/bqaa154.
50.Zachariah P, Johnson CL, Halabi KC, Ahn D, Sen AI, Fischer A, et al. Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (COVID-19) in a children's hospital in New York City, New York. JAMA Pediatr. 2020;174:e202430. https://doi.org/10.1001/jamapediatrics.2020.2430.
51.Aung N, Khanji MY, Munroe PB, Petersen SE. Causal inference for genetic obesity, cardiometabolic profile and COVID-19 susceptibility: a Mendelian randomization study. Front Genet. 2020;11:586308. https://doi.org/10.3389/fgene.2020.586308.
CAS Article PubMed PubMed Central Google Scholar
52.Zheng KI, Gao F, Wang XB, Sun QF, Pan KH, Wang TY, et al. Letter to the editor: obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease. Metabolism. 2020;108:154244. https://doi.org/10.1016/j.metabol.2020.154244.
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