Melatonin: Revisited Role as Vaccine Adjuvant During Outbreaks of COVID-19 Caused by the Delta Variant

Baghban Rahimi S, Mohebbi A, Vakilzadeh G, Biglari P, Jahromi SR, Mohebi SR, Shirian S, Gorji A, Ghaemi A (2018) Enhancement of therapeutic DNA vaccine potency by melatonin through inhibiting VEGF expression and induction of antitumor immunity mediated by CD8 + T cells. Arch Virol 163(3):587–597

CAS  Article  Google Scholar 

Favresse J, Bayart JL, Mullier F, Elsen M, Eucher C, Van Eeckhoudt S, Roy T, Wieers G, Laurent C, Dogné JM, Closset M, Douxfils J (2021) Antibody titres decline 3-month post-vaccination with BNT162b2. Emerg Microbes Infect 10(1):1495–1498

CAS  Article  Google Scholar 

Jordan SC, Shin BH, Gadsden TM, Chu M, Petrosyan A, Le CN, Zabner R, Oft J, Pedraza I, Cheng S, Vo A, Ammerman N, Plummer J, Ge S, Froch M, Berg A, Toyoda M, Zhang R (2021) T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals. Cell Mol Immunol 16:1–3

Google Scholar 

Lissoni P, Vigorè L, Rescaldani R, Rovelli F, Brivio F, Giani L, Barni S, Tancini G, Ardizzoia A, Viganò MG (1995) Neuroimmunotherapy with low-dose subcutaneous interleukin-2 plus melatonin in AIDS patients with CD4 cell number below 200/mm3: a biological phase-II study. J Biol Regul Homeost Agents 9(4):155–158

CAS  PubMed  Google Scholar 

Lopez Bernal J, Andrews N, Gower C, Gallagher E, Simmons R, Thelwall S, Stowe J, Tessier E, Groves N, Dabrera G, Myers R, Campbell CNJ, Amirthalingam G, Edmunds M, Zambon M, Brown KE, Hopkins S, Chand M, Ramsay M (2021) Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant. N Engl J Med 385(7):585–594

Maestroni G (2020) Exogenous melatonin as potential adjuvant in anti-SarsCov2 vaccines. J Neuroimmune Pharmacol 15(4):572–573

Article  Google Scholar 

Naaber P, Tserel L, Kangro K, Sepp E, Jürjenson V, Adamson A, Haljasmägi L, Rumm AP, Maruste R, Kärner J, Gerhold JM, Planken A, Ustav M, Kisand K, Peterson P (2021) Dynamics of antibody response to BNT162b2 vaccine after six months: a longitudinal prospective study. Lancet Reg Health Eur 6:100208

Noh JY, Jeong HW, Kim JH, Shin EC (2021) T cell-oriented strategies for controlling the COVID-19 pandemic. Nat Rev Immunol 8:1–2

Google Scholar 

Ramos A, Míguez MP, Morgado S, Sanchez-Correa B, Gordillo JJ, Casado JG, Tarazona R, Regodon S (2008) Melatonin enhances responsiveness to Dichelobacter nodosus vaccine in sheep and increases peripheral blood CD4 T lymphocytes and IgG-expressing B lymphocytes. Vet Immunol Immunopathol 206:1–8

Article  Google Scholar 

Sheikh A, McMenamin J, Taylor B, Robertson C, Scotland PH, the EAVE II Collaborators, (2021) SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness. Lancet 397(10293):2461–2462

CAS  Article  Google Scholar 

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