Analgesic characteristics of a newly developed α2δ ligand, mirogabalin, on inflammatory pain

1. Attal, N . Pharmacological treatments of neuropathic pain: the latest recommendations. Rev Neurol (Paris) 2019; 175: 46–50.
Google Scholar | Crossref | Medline2. Finnerup, NB, Attal, N, Haroutounian, S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015; 14: 162–173.
Google Scholar | Crossref | Medline | ISI3. Moulin, D, Boulanger, A, Clark, A, et al. Pharmacological management of chronic neuropathic pain: revised consensus statement from the canadian pain society. Pain Res Manag 2014; 19: 328–335.
Google Scholar | Crossref | Medline | ISI4. Domon, Y, Arakawa, N, Inoue, T, et al. Binding characteristics and analgesic effects of mirogabalin, a Novel Ligand for the α2δ subunit of voltage-gated calcium channels. J Pharmacol Exp Ther 2018; 365: 573–582.
Google Scholar | Crossref | Medline5. Dolphin, AC . The α2δ subunits of voltage-gated calcium channels. Biochim Biophys Acta 2013; 1828: 1541–1549.
Google Scholar | Crossref | Medline | ISI6. Field, MJ, Cox, PJ, Stott, E, et al. Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A 2006; 103: 17537–17542.
Google Scholar | Crossref | Medline | ISI7. Geisler, S, Schöpf, CL, Obermair, GJ. Emerging evidence for specific neuronal functions of auxiliary calcium channel α2δ subunits. Gen Physiol Biophys 2015; 34: 105–118.
Google Scholar | Crossref | Medline8. Marais, E, Klugbauer, N, Hofmann, F. Calcium channel α2δ subunits structure and gabapentin binding. Mol Pharmacol 2001; 59: 1243–1248.
Google Scholar | Crossref | Medline | ISI9. Qin, N, Yagel, S, Momplaisir, M-L, et al. Molecular cloning and characterization of the human voltage-gated calcium channel α2δ-4 subunit. Mol Pharmacol 2002; 62: 485–496.
Google Scholar | Crossref | Medline10. Taylor, CP, Angelotti, T, Fauman, E. Pharmacology and mechanism of action of pregabalin: the calcium channel α2−δ (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007; 73: 137–150.
Google Scholar | Crossref | Medline | ISI11. Kato, J, Matsui, N, Kakehi, Y, et al. Mirogabalin for the management of postherpetic neuralgia: a randomized, double-blind, placebo-controlled phase 3 study in Asian patients. Pain 2019; 160: 1175–1185.
Google Scholar | Crossref | Medline12. Baba, M, Matsui, N, Kuroha, M, et al. Mirogabalin for the treatment of diabetic peripheral neuropathic pain: a randomized, double‐blind, placebo‐controlled phase III study in Asian patients. J Diabetes Investig 2019; 10: 1299–1306.
Google Scholar | Crossref | Medline13. Arnold, LM, Whitaker, S, Hsu, C, et al. Efficacy and safety of mirogabalin for the treatment of fibromyalgia: results from three 13-week randomized, double-blind, placebo- and active-controlled, parallel-group studies and a 52-week open-label extension study. Curr Med Res Opin 2019; 35: 1825–1835.
Google Scholar | Crossref | Medline14. Kremer, M, Salvat, E, Muller, A, et al. Antidepressants and gabapentinoids in neuropathic pain: mechanistic insights. Neuroscience 2016; 338: 183–206.
Google Scholar | Crossref | Medline | ISI15. Chincholkar, M . Analgesic mechanisms of gabapentinoids and effects in experimental pain models: a narrative review. Br J Anaesth 2018; 120: 1315–1334.
Google Scholar | Crossref | Medline16. Tanabe, M, Takasu, K, Kasuya, N, et al. Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse. Br J Pharmacol 2005; 144: 703–714.
Google Scholar | Crossref | Medline | ISI17. Hayashida, K-i, Obata, H, Nakajima, K, et al. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology 2008; 109: 1077–1084.
Google Scholar | Crossref | Medline | ISI18. Yamamoto, T, Yaksh, TL. Comparison of the anti-nociceptive effects of pre- and post-treatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiolgy 1992; 77: 757–763.
Google Scholar | Crossref | Medline | ISI19. Nakamura, S, Nonaka, T, Yoshida, K, et al. An endogenous NPBW1 and NPBW2 ligand, produced an analgesic effect via activation of the descending pain modulatory system during a rat formalin test. Mol Pain 2021; 17: 1–9.
Google Scholar | SAGE Journals20. Biggs, JE, Boakye, PA, Ganesan, N, et al. Analysis of the long-term actions of gabapentin and pregabalin in dorsal root ganglia and substantia gelatinosa. J Neurophysiol 2014; 112: 2398–2412.
Google Scholar | Crossref | Medline | ISI21. Kitano, Y, Wakimoto, S, Tamura, S, et al. Effects of mirogabalin, a novel ligand for the α2δ subunit of voltage-gated calcium channels, on N-type calcium channel currents of rat dorsal root ganglion culture neurons. Pharmazie 2019; 74: 147–149.
Google Scholar | Medline22. Hummig, W, Kopruszinski, CM, Chichorro, JG. Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain. J Oral Facial Pain Headache 2014; 28: 350–359.
Google Scholar | Crossref | Medline23. Bockbrader, HN, Wesche, D, Miller, R, et al. Comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet 2010; 49: 661–669.
Google Scholar | Crossref | Medline | ISI24. Brown, K, Mendell, J, Ohwada, S, et al. Tolerability, pharmacokinetics, and pharmacodynamics of mirogabalin in healthy subjects: results from phase 1 studies. Pharmacol Res Perspect 2018; 6: e00418.
Google Scholar | Crossref | Medline25. Buvanendran, A, Kroin, JS, Kari, M, et al. Can a single dose of 300 mg of pregabalin reach acute antihyperalgesic levels in the central nervous system? Reg Anesth Pain Med 2010; 35: 535–538.
Google Scholar | Crossref | Medline26. Sturman, O, Germain, P-L, Bohacek, J. Exploratory rearing: a context- and stress-sensitive behavior recorded in the open-field test. Stress 2018; 21: 443–452.
Google Scholar | Crossref | Medline27. Bauer, CS, Nieto-Rostro, M, Rahman, W, et al. The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin. J Neurosci 2009; 29: 4076–4088.
Google Scholar | Crossref | Medline | ISI28. Hoppa, MB, Lana, B, Margas, W, et al. α2δ expression sets presynaptic calcium channel abundance and release probability. Nature 2012; 486: 122–125.
Google Scholar | Crossref | Medline | ISI29. Oyama, M, Watanabe, S, Iwai, T, et al. Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects. J Pharmaol Sci 2021; 146: 33–39.
Google Scholar | Crossref | Medline30. Suzuki, R, Rahman, W, Rygh, LJ, et al. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain 2005; 117: 292–303.
Google Scholar | Crossref | Medline | ISI31. Rocha-González, HI, Meneses, A, Carlton, SM, et al. Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test. Pain 2005; 117: 182–192.
Google Scholar | Crossref | Medline

留言 (0)

沒有登入
gif