Thrombosis and Bleeding After Implementation of an Intermediate-Dose Prophylactic Anticoagulation Protocol in ICU Patients With COVID-19: A Multicenter Screening Study

1. Iba, T, Levy, JH, Levi, M, Connors, JM, Thachil, J. Coagulopathy of coronavirus disease 2019. Crit Care Med. 2020;48(9):1358‐1364. doi:10.1097/CCM.0000000000004458
Google Scholar | Crossref | Medline2. Klok, FA, Kruip, MJHA, van der Meer, NJM, et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb Res. 2020;191:148‐150. doi:10.1016/j.thromres.2020.04.041
Google Scholar | Crossref | Medline3. Helms, J, Tacquard, C, Severac, F, et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: A multicenter prospective cohort study. Intensive Care Med. 2020;46(6):1089‐1098. doi:10.1007/s00134-020-06062-x
Google Scholar | Crossref | Medline4. Poissy, J, Goutay, J, Caplan, M, et al. Pulmonary embolism in patients with COVID-19: Awareness of an increased prevalence. Circulation. 2020;142(2):184‐186. doi:10.1161/CIRCULATIONAHA.120.047430
Google Scholar | Crossref | Medline5. Middeldorp, S, Coppens, M, van Haaps, TF, et al. Incidence of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost. 2020;18(8):1995‐2002. doi:10.1111/jth.14888
Google Scholar | Crossref | Medline6. Nahum, J, Morichau-Beauchant, T, Daviaud, F, et al. Venous thrombosis among critically ill patients with coronavirus disease 2019 (COVID-19). JAMA Netw Open. 2020;3(5):e2010478. Published 2020 May 1. doi:10.1001/jamanetworkopen.2020.10478
Google Scholar | Crossref | Medline7. Tavazzi, G, Civardi, L, Caneva, L, Mongodi, S, Mojoli, F. Thrombotic events in SARS-CoV-2 patients: An urgent call for ultrasound screening. Intensive Care Med. 2020;46(6):1121‐1123. doi:10.1007/s00134-020-06040-3
Google Scholar | Crossref | Medline8. Ren, B, Yan, F, Deng, Z, et al. Extremely high incidence of lower extremity deep venous thrombosis in 48 patients with severe COVID-19 in Wuhan. Circulation. 2020;142(2):181‐183. doi:10.1161/CIRCULATIONAHA.120.047407
Google Scholar | Crossref | Medline9. Desborough, MJR, Doyle, AJ, Griffiths, A, Retter, A, Breen, KA, Hunt, BJ. Image-proven thromboembolism in patients with severe COVID-19 in a tertiary critical care unit in the United Kingdom. Thromb Res. 2020;193:1‐4. doi:10.1016/j.thromres.2020.05.049
Google Scholar | Crossref | Medline10. Mirsadraee, S, Gorog, DA, Mahon, CF, et al. Prevalence of thrombotic complications in ICU-treated patients with coronavirus disease 2019 detected with systematic CT scanning. Crit Care Med. 2021;49(5):804‐815. doi:10.1097/CCM.0000000000004890
Google Scholar | Crossref | Medline11. Suh, YJ, Hong, H, Ohana, M, et al. Pulmonary embolism and deep vein thrombosis in COVID-19: A systematic review and meta-analysis. Radiology. 2021;298(2):E70‐E80. doi:10.1148/radiol.2020203557
Google Scholar | Crossref | Medline12. Bonaventura, A, Vecchié, A, Dagna, L, et al. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol. 2021;21(5):319‐329. doi:10.1038/s41577-021-00536-9
Google Scholar | Crossref | Medline13. Jiménez, D, García-Sanchez, A, Rali, P, et al. Incidence of VTE and bleeding among hospitalized patients with coronavirus disease 2019: A systematic review and meta-analysis. Chest. 2021;159(3):1182‐1196. doi:10.1016/j.chest.2020.11.005
Google Scholar | Crossref | Medline14. Piazza, G, Campia, U, Hurwitz, S, et al. Registry of arterial and venous thromboembolic complications in patients with COVID-19. J Am Coll Cardiol. 2020;76(18):2060‐2072. doi:10.1016/j.jacc.2020.08.070
Google Scholar | Crossref | Medline15. Spyropoulos, AC, Levy, JH, Ageno, W, et al. Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID-19. J Thromb Haemost. 2020;18(8):1859‐1865. doi:10.1111/jth.14929
Google Scholar | Crossref | Medline16. NICE Guideline [NG 191]: COVID-19 rapid guideline: managing COVID-19. National Institute for Health and Care Excellence; 2021. Available at: https://www.nice.org.uk/guidance/ng191/resources/covid19-rapid-guideline-managing-covid19-pdf-51035553326. Accessed May 11, 2021
Google Scholar17. INSPIRATION Investigators , Sadeghipour, P, Talasaz, AH, et al. Effect of intermediate-dose vs standard-dose prophylactic anticoagulation on thrombotic events, extracorporeal membrane oxygenation treatment, or mortality among patients with COVID-19 admitted to the intensive care unit: The INSPIRATION randomized clinical trial. JAMA. 2021;325(16):1620‐1630. doi:10.1001/jama.2021.4152
Google Scholar | Crossref | Medline18. Longchamp, A, Longchamp, J, Manzocchi-Besson, S, et al. Venous thromboembolism in critically ill patients with COVID-19: Results of a screening study for deep vein thrombosis. Res Pract Thromb Haemost. 2020;4(5):842‐847. Published 2020 Jun 30. doi:10.1002/rth2.12376
Google Scholar | Crossref | Medline19. Voicu, S, Bonnin, P, Stépanian, A, et al. High prevalence of deep vein thrombosis in mechanically ventilated COVID-19 patients. J Am Coll Cardiol. 2020;76(4):480‐482. doi:10.1016/j.jacc.2020.05.053
Google Scholar | Crossref | Medline20. Raskob, GE, Spyropoulos, AC, Cohen, AT, et al. Association between asymptomatic proximal deep vein thrombosis and mortality in acutely ill medical patients. J Am Heart Assoc. 2021;10(5):e019459. doi:10.1161/JAHA.120.019459
Google Scholar | Crossref | Medline21. Alhazzani, W, Evans, L, Alshamsi, F, et al. Surviving sepsis campaign guidelines on the management of adults with coronavirus disease 2019 (COVID-19) in the ICU: First update. Crit Care Med. 2021;49(3):e219‐e234. doi:10.1097/CCM.0000000000004899
Google Scholar | Crossref | Medline22. Shiloh, AL, McPhee, C, Eisen, L, Koenig, S, Millington, SJ. Better with ultrasound: detection of DVT. Chest. 2020;158(3):1122‐1127. doi:10.1016/j.chest.2020.01.038
Google Scholar | Crossref | Medline23. Schulman, S, Kearon, C. Subcommittee on control of anticoagulation of the scientific and standardization committee of the international society on thrombosis and haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. J Thromb Haemost. 2005;3(4):692‐694. doi:10.1111/j.1538-7836.2005.01204.x
Google Scholar | Crossref | Medline | ISI24. Kaatz, S, Ahmad, D, Spyropoulos, AC, Schulman, S. Subcommittee on control of anticoagulation. Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH. J Thromb Haemost. 2015;13(11):2119‐2126. doi:10.1111/jth.13140
Google Scholar | Crossref | Medline25. Llitjos, JF, Leclerc, M, Chochois, C, et al. High incidence of venous thromboembolic events in anticoagulated severe COVID-19 patients. J Thromb Haemost. 2020;18(7):1743‐1746. doi:10.1111/jth.14869
Google Scholar | Crossref | Medline26. Criel, M, Falter, M, Jaeken, J, et al. Venous thromboembolism in SARS-CoV-2 patients: only a problem in ventilated ICU patients, or is there more to it? Eur Respir J. 2020;56(1):2001201. Published 2020 Jul 30. doi:10.1183/13993003.01201-2020
Google Scholar | Crossref | Medline27. Zerwes, S, Hernandez Cancino, F, Liebetrau, D, et al. Erhöhtes Risiko für tiefe Beinvenenthrombosen bei Intensivpatienten mit COVID-19-Infektion? – Erste Daten [Increased risk of deep vein thrombosis in intensive care unit patients with CoViD-19 infections?-Preliminary data] [published correction appears in Chirurg. 2020 Jun 29;:]. Chirurg. 2020;91(7):588‐594. doi:10.1007/s00104-020-01222-7
Google Scholar | Crossref | Medline28. Chen, S, Zhang, D, Zheng, T, Yu, Y, Jiang, J. DVT incidence and risk factors in critically ill patients with COVID-19. J Thromb Thrombolysis. 2021;51(1):33‐39. doi:10.1007/s11239-020-02181-w
Google Scholar | Crossref | Medline29. Moll, M, Zon, RL, Sylvester, KW, et al. VTE in ICU patients with COVID-19. Chest. 2020;158(5):2130‐2135. doi:10.1016/j.chest.2020.07.031
Google Scholar | Crossref | Medline30. Al-Samkari, H, Karp Leaf, RS, Dzik, WH, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood. 2020;136(4):489‐500. doi:10.1182/blood.2020006520
Google Scholar | Crossref | Medline31. Nopp, S, Moik, F, Jilma, B, Pabinger, I, Ay, C. Risk of venous thromboembolism in patients with COVID-19: A systematic review and meta-analysis [published online ahead of print, 2020 Sep 25]. Res Pract Thromb Haemost. 2020;4(7):1178‐1191. doi:10.1002/rth2.12439
Google Scholar | Crossref32. ATTACC Investigators, ACTIV-4a Investigators, REMAP-CAP Investigators , et al. Therapeutic anticoagulation with heparin in noncritically ill patients with COVID-19 [published online ahead of print, 2021 Aug 4]. N Engl J Med. 2021;10.1056. doi:10.1056/NEJMoa2105911
Google Scholar | Crossref33. REMAP-CAP Investigators, ACTIV-4a Investigators, ATTACC Investigators , et al. Therapeutic anticoagulation with heparin in critically ill patients with COVID-19 [published online ahead of print, 2021 Aug 4]. N Engl J Med. 2021. doi:10.1056/NEJMoa2103417
Google Scholar | Crossref34. Moll, M, Zon, RL, Sylvester, KW, et al. Intermediate versus standard dose heparin prophylaxis in COVID-19 ICU patients: A propensity score-matched analysis [published online ahead of print, 2021 Apr 19]. Thromb Res. 2021;203:57‐60. doi:10.1016/j.thromres.2021.04.009
Google Scholar | Crossref | Medline35. De Cobelli, F, Palumbo, D, Ciceri, F, et al. Pulmonary vascular thrombosis in COVID-19 pneumonia [published online ahead of print, 2021 Jan 13]. J Cardiothorac Vasc Anesth. 2021;S1053-0770(21):00013‐6. doi:10.1053/j.jvca.2021.01.011
Google Scholar | Crossref36. Tomashefski, JF, Davies, P, Boggis, C, Greene, R, Zapol, WM, Reid, LM. The pulmonary vascular lesions of the adult respiratory distress syndrome. Am J Pathol. 1983;112(1):112‐126.
Google Scholar | Medline | ISI37. Chandra, A, Chakraborty, U, Ghosh, S, Dasgupta, S. Anticoagulation in COVID-19: current concepts and controversies [published online ahead of print, 2021 Apr 13]. Postgrad Med J. 2021; doi:10.1136/postgradmedj-2021–139923
Google Scholar | Crossref38. O’Donnell, JS, Peyvandi, F, Martin-Loeches, I. Pulmonary immuno-thrombosis in COVID-19 ARDS pathogenesis. Intensive Care Med. 2021;47(8):899‐902. doi:10.1007/s00134-021-06419-w
Google Scholar | Crossref | Medline39. Fox, SE, Akmatbekov, A, Harbert, JL, Li, G, Quincy Brown, J, Vander Heide, RS. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. Lancet Respir Med. 2020;8(7):681‐686. doi:10.1016/S2213-2600(20)30243-5
Google Scholar | Crossref | Medline40. Ackermann, M, Verleden, SE, Kuehnel, M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in COVID-19. N Engl J Med. 2020;383(2):120‐128. doi:10.1056/NEJMoa2015432
Google Scholar | Crossref | Medline41. Roberts, L, Rozen, T, Murphy, D, et al. A preliminary study of intensivist-performed DVT ultrasound screening in trauma ICU patients (APSIT study). Ann Intensive Care. 2020;10(1):122. Published 2020 Sep 14. doi:10.1186/s13613-020-00739-8.
Google Scholar | Crossref | Medline42. Hussain, A, Via, G, Melniker, L, et al. Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus. Crit Care. 2020;24(1):702. Published 2020 Dec 24. doi:10.1186/s13054-020-03369-5
Google Scholar | Crossref | Medline43. Arabi, YM, Burns, KEA, Alsolamy, SJ, et al. Surveillance or no surveillance ultrasonography for deep vein thrombosis and outcomes of critically ill patients: a pre-planned sub-study of the PREVENT trial. Intensive Care Med. 2020;46(4):737‐746. doi:10.1007/s00134-019-05899-1

留言 (0)

沒有登入
gif