Enhancing preclinical drug discovery with artificial intelligence

Vijayan Ramaswamy Vijayan Ramaswamy (R.S.K Vijayan) is a research scientist at the Institute for Applied Cancer Science, University of Texas MD Anderson Cancer, TX, USA. Before starting at the MD Anderson Cancer in 2016, he was a postdoctoral fellow at Rutgers University, NJ, USA, and at Temple University, PA, USA. He received his PhD as a CSIR senior research fellow from the Indian Institute of Chemical Biology, Kolkata, India. His research focuses on applying computational chemistry methods to drive small-molecule drug discovery programs in oncology and neurodegenerative diseases.

Jan Kihlberg Jan Kihlberg has held a chair in Organic Chemistry at Uppsala University (Sweden) since 2013. Before moving to Uppsala, he spent 10 years at AstraZeneca R&D in Gothenburg, seven of which as Director of Medicinal Chemistry. He was appointed professor in bioorganic chemistry at Umeå University in 1996, after having established his independent research group at Lund University in 1991. Currently, his main research interest is to understand what properties convey cell permeability, oral bioavailability, and target binding to drugs in the beyond rule of 5 space, in particular macrocycles and PROTACs.

Jason B. Cross Jason B. Cross leads the Structural Chemistry group at the Institute for Applied Cancer Science, University of Texas MD Anderson Cancer Center, TX, USA. Before joining MD Anderson in 2015, he provided computational chemistry support for drug discovery projects at Affinium Pharmaceuticals and Wyeth Pharmaceuticals, and led the molecular modeling group at Cubist Pharmaceuticals. He received his PhD from Wayne State University, MI, USA, before completing a postdoctoral fellowship at Pfizer Inc. in Ann Arbor, MI, USA. His research focuses on the application of computational methods to support small-molecule drug discovery.

Vasanthanathan Poongavanam Vasanthanathan Poongavanam is a researcher in the Department of Chemistry-BMC, Uppsala University, Sweden. Before starting at Uppsala University in a postdoctoral position with Jan Kihlberg in 2016, he was a postdoctoral fellow at the University of Vienna, Austria, and at the University of Southern Denmark. He obtained his PhD in medicinal chemistry as a Drug Research Academy Fellow at the University of Copenhagen, Denmark, on computational modeling of Cytochrome P450. His research interests focus on understanding the molecular properties that govern the pharmacokinetic profile of molecules beyond the Ro5 space, including macrocycles and PROTACs.

© 2021 The Author(s). Published by Elsevier Ltd.

留言 (0)

沒有登入
gif