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Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation
Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation
Protein translation regulation is a crucial and tightly controlled regulatory process that contribute...
Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2
Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2
Human coronaviruses are pathogens capable of causing respiratory illnesses in humans, with seven iden...
Prediction of Behavioral Problems Based on Attachment Styles and Sensory Processing in Children with a History of Prematurity at Birth
Abstract Background: Despite significant advancements in the care of premature infants, it must be acknowledged that pre...
Improving Attitudes and Inclination towards Neonatal Feeding with Milk donated from Milk Bank in Mothers with Premature Neonates: A Comparison of Two Educational Interventions
Background & Objective: Milk bank is one of the most important emerging issues in the field of neonatal health. The pr...
Comparison of combined Apgar score and umbilical cord arterial blood gas in prediction of poor short term outcomes in neonates
Introduction: Apgar scoring system, including conventional, expanded and combined Apgar scores have been used to evaluate ...
Management of anorectal malformations: A five-year experience from a tertiary care center of southern Iraq
Background: Anorectal malformations are the most common congenital anomalies of the gastrointestinal tract in pediatric su...
RADIO-TARTAGLIA SYNDROME: A RARE CAUSE OF DELAY IN NEURODEVELOPMENT – A CASE REPORT
Background: Radio-Tartaglia syndrome or RATARS is an unfamiliar disease caused by an heterozygous mutation of the SPEN gen...
Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway
Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway
Background:The COBLL1 gene has been implicated in human central obesity, fasting insulin levels, type 2 diabetes, and bloo...
Cardiac fibroblasts in heart failure and regeneration
Cardiac fibroblasts in heart failure and regeneration
In heart disease patients, myocyte loss or malfunction invariably leads to fibrosis, involving the activation and accumula...
Editorial: Protein kinase inhibitors in neurodegeneration and cancer targeted therapies
Editorial: Protein kinase inhibitors in neurodegeneration and cancer targeted therapies
Protein kinases play roles in diverse cellular functions, with approximately 2% of the human genome dedicated to encoding ...
Editorial: Intervertebral disc degeneration: mechanisms and therapeutics
Editorial: Intervertebral disc degeneration: mechanisms and therapeutics
Low back pain (LBP) is a prevalent musculoskeletal disorder, affecting approximately 70% of individuals at some point in t...
Vitamin D effects on Chlamydia trachomatis infection: a case-control and experimental study
Vitamin D effects on Chlamydia trachomatis infection: a case-control and experimental study
IntroductionVitamin D deficiency is the most common nutritional deficiency worldwide. Chronic vitamin D deficiency causes ...
Tissue-specific localization of tick-borne pathogens in ticks collected from camels in Kenya: insights into vector competence
Tissue-specific localization of tick-borne pathogens in ticks collected from camels in Kenya: insights into vector competence
BackgroundTick-borne pathogen (TBP) surveillance studies often use whole-tick homogenates when inferring tick-pathogen ass...
Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry
Cellugyrin (synaptogyrin-2) dependent pathways are used by bacterial cytolethal distending toxin and SARS-CoV-2 virus to gain cell entry
Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is capable of intoxicating lymphocytes macrophages...
Insights into the molecular phylogeny and morphology of three novel Dothiora species, along with a worldwide checklist of Dothiora
Insights into the molecular phylogeny and morphology of three novel Dothiora species, along with a worldwide checklist of Dothiora
Most species of Dothiora are known from the dead parts of various host plants as saprobic fungi in terrestrial habitats oc...
Uncovering specific taxonomic and functional alteration of gut microbiota in chronic kidney disease through 16S rRNA data
Uncovering specific taxonomic and functional alteration of gut microbiota in chronic kidney disease through 16S rRNA data
IntroductionChronic kidney disease (CKD) is worldwide healthcare burden with growing incidence and death rate. Emerging ev...
Case report: Chronic Candida albicans meningitis: a rare entity diagnosed by metagenomic next-generation sequencing
Case report: Chronic Candida albicans meningitis: a rare entity diagnosed by metagenomic next-generation sequencing
The aetiology of chronic aseptic meningitis is difficult to establish. Candida meningitis in particular is often diagnosed...
Yeast species in the respiratory samples of COVID-19 patients; molecular tracking of Candida auris
Yeast species in the respiratory samples of COVID-19 patients; molecular tracking of Candida auris
IntroductionAlthough the existence of Candida species in the respiratory tract is often considered commensal, it is crucia...
Expression of Toll-like receptors in the cerebellum during pathogenesis of prion disease
Expression of Toll-like receptors in the cerebellum during pathogenesis of prion disease
Prion diseases, such as scrapie, entail the accumulation of disease-specific prion protein (PrPSc) within the brain. Toll-...
SV2A PET imaging in human neurodegenerative diseases
SV2A PET imaging in human neurodegenerative diseases
This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrit...
Neuroanatomical correlates of distracted straight driving performance: a driving simulator MRI study across the lifespan
Neuroanatomical correlates of distracted straight driving performance: a driving simulator MRI study across the lifespan
BackgroundDriving is the preferred mode of transportation for adults across the healthy age span. However, motor vehicle c...
Incidence and risk factors of age-related macular degeneration in patients with Parkinson’s disease: a population-based study
Incidence and risk factors of age-related macular degeneration in patients with Parkinson’s disease: a population-based study
Background and objectiveThe association between age-related macular degeneration (AMD) and Parkinson’ disease (PD) remains...
Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application
Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application
Metastasis poses a major challenge in colorectal cancer (CRC) treatment and remains a primary cause of mortality among pat...
Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration
Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration
Neurodegenerative diseases are increasingly recognized for their association with oxidative stress, which leads to progres...
Community-oriented primary care footprinting: An undergraduate programme experience
The South African Family Practice is a peer-reviewed scientific journal, which strives to provide primary care physicians ...
Palliative care in the emergency department: An observational study of doctors in KwaZulu-Natal
The South African Family Practice is a peer-reviewed scientific journal, which strives to provide primary care physicians ...
circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood–brain barrier integrity and cognitive function in uremic encephalopathy
circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood–brain barrier integrity and cognitive function in uremic encephalopathy
Uremic encephalopathy (UE) poses a significant challenge in neurology, leading to the need to investigate the involvement ...
Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
Activation of CTU2 expression by LXR promotes the development of hepatocellular carcinoma
Cytosolic thiouridylase 2 (CTU2) is an enzyme modifying transfer RNAs post-transcriptionally, which has been implicated in...
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage
LAMC1 attenuates neuronal apoptosis via FAK/PI3K/AKT signaling pathway after subarachnoid hemorrhage
Subarachnoid hemorrhage (SAH) accounts for 5–10% of all strokes, of which about 80% are caused by ruptured aneurysms, with...
An improved method for generating human spinal cord neural stem cells
An improved method for generating human spinal cord neural stem cells
Human neural stem cells and neural progenitor cells have been tested in a variety of CNS disorders, including spinal cord ...
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