High prevalence of CFHR deletions in Indian women with pregnancy‐associated hemolytic uremic syndrome

Background and objectives

Pregnancy-associated hemolytic uremic syndrome (P-aHUS) is an important cause of peripartum acute kidney injury). Studies from Europe have described mutations in complement regulator genes, while the data in Indian P-aHUS patients is scarce.

Methods

We present 17 patients of P-aHUS who were investigated for complement protein levels and genetic analysis with multiplex ligation-dependent probe amplification (MLPA) for complement genes. Plasma exchange therapy was offered to all patients presenting in acute phase.

Results

Mean age 26.74 (3.36) years with 15/17 delivered by cesarean section. Eleven patients received early (within 7 days) plasma exchange, three were dialysis-dependent at 3 months and seven were dialysis-free. Only one of the three patients receiving late (after 7 days) plasma exchange was dialysis-free. MLPA showed that 11 patients had heterozygous deletions of exons 3, 5, 6 of CFHR1 and upstream region of exons 1, 2, 3, 6 and intron 4 of CFHR3 gene while four patients had homozygous deletions at the same loci. Two patients had no MLPA-detectable variations.

Conclusions

This study reports a high proportion of deletions of exons of CFHR1 & CFHR3 genes in Indian P-aHUS patients detectable by MLPA by copy number variations. This needs confirmation in large multi-center studies. Plasma exchange can be an effective therapy in the non-availability of Eculizumab.

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