1. Vincent, J-L, Opal, SM, Marshall, JC, Tracey, KJ. Sepsis definitions: time for change. Lancet Lond Engl. 2013;381(9868):774-775. doi:10.1016/S0140-6736(12)61815-7
Google Scholar | Crossref | Medline2. Wiersinga, WJ, Leopold, SJ, Cranendonk, DR, van der Poll, T. Host innate immune responses to sepsis. Virulence. 2014;5(1):36-44. doi:10.4161/viru.25436
Google Scholar | Crossref | Medline | ISI3. Gaieski, DF, Edwards, JM, Kallan, MJ, Carr, BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013;41(5):1167-1174. doi:10.1097/CCM.0b013e31827c09f8
Google Scholar | Crossref | Medline | ISI4. Kumar, G, Kumar, N, Taneja, A, et al. Nationwide trends of severe sepsis in the 21st century (2000-2007). Chest. 2011;140(5):1223-1231. doi:10.1378/chest.11-0352
Google Scholar | Crossref | Medline | ISI5. Yo, C-H, Lai, C-C, Hsu, T-C, et al. National trends of organ dysfunctions in sepsis: an 11-year longitudinal population-based cohort study. J Acute Med. 2019;9(4):178-188. doi:10.6705/j.jacme.201912_9(4).0004
Google Scholar | Crossref | Medline6. Rivers, E, Nguyen, B, Havstad, S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345(19):1368-1377. doi:10.1056/NEJMoa010307
Google Scholar | Crossref | Medline | ISI7. Singer, M, Deutschman, CS, Seymour, CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287
Google Scholar | Crossref | Medline | ISI8. Martin, GS, Mannino, DM, Eaton, S, Moss, M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348(16):1546-1554. doi:10.1056/NEJMoa022139
Google Scholar | Crossref | Medline | ISI9. Baldo, V, Cocchio, S, Gallo, T, et al. Pneumococcal conjugated vaccine reduces the high mortality for community-acquired pneumonia in the elderly: an Italian regional experience. PloS One. 2016;11(11):e0166637. doi:10.1371/journal.pone.0166637
Google Scholar | Crossref | Medline10. Rhee, C, Dantes, R, Epstein, L, et al. Incidence and trends of sepsis in US hospitals using clinical versus claims data, 2009-2014. JAMA. 2017;318(13):1241-1249. doi:10.1001/jama.2017.13836
Google Scholar | Crossref | Medline11. Langley, G, Schaffner, W, Farley, MM, et al. Twenty years of active bacterial core surveillance. Emerg Infect Dis. 2015;21(9):1520-1528. doi:10.3201/eid2109.141333
Google Scholar | Crossref | Medline12. HCUP Nationwide Inpatient Sample (NIS). Healthcare Cost and Utilization Project (HCUP). 2011. Agency for Healthcare Research and Quality, Rockville, MD. Accessed July 11, 2021. https://www.hcup-us.ahrq.gov/nisoverview.jsp
Google Scholar13. Sehgal, M, Ladd, HJ, Totapally, B. Trends in epidemiology and microbiology of severe sepsis and septic shock in children. Hosp Pediatr. 2020;10(12):1021-1030. doi:10.1542/hpeds.2020-0174
Google Scholar | Crossref | Medline14. Liu, MA, Bakow, BR, Hsu, T-C, et al. Temporal trends in sepsis incidence and mortality in patients With cancer in the US population. Am J Crit Care Off Publ Am Assoc Crit-Care Nurses. 2021;30(4):e71-e79. doi:10.4037/ajcc2021632
Google Scholar | Crossref | Medline15. Moore, BJ, White, S, Washington, R, Coenen, N, Elixhauser, A. Identifying increased risk of readmission and In-hospital mortality using hospital administrative data: the AHRQ Elixhauser Comorbidity Index. Med Care. 2017;55(7):698-705. doi:10.1097/MLR.0000000000000735
Google Scholar | Crossref | Medline16. Goto, T, Yoshida, K, Tsugawa, Y, Filbin, MR, Camargo, CA, Hasegawa, K. Mortality trends in U.S. adults with Septic shock, 2005-2011: a serial cross-sectional analysis of nationally-representative data. BMC Infect Dis. 2016;16:294. doi:10.1186/s12879-016-1620-1
Google Scholar | Crossref | Medline17. Kaukonen, K-M, Bailey, M, Suzuki, S, Pilcher, D, Bellomo, R. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA. 2014;311(13):1308-1316. doi:10.1001/jama.2014.2637
Google Scholar | Crossref | Medline | ISI18. Esper, AM, Martin, GS. Extending international sepsis epidemiology: the impact of organ dysfunction. Crit Care Lond Engl. 2009;13(1):120. doi:10.1186/cc7704
Google Scholar | Crossref | Medline19. Harrison, DA, Welch, CA, Eddleston, JM. The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care Lond Engl. 2006;10(2):R42. doi:10.1186/cc4854
Google Scholar | Crossref | Medline20. Danai, P, Martin, GS. Epidemiology of sepsis: recent advances. Curr Infect Dis Rep. 2005;7(5):329-334. doi:10.1007/s11908-005-0005-1
Google Scholar | Crossref | Medline21. Mayr, FB, Yende, S, Angus, DC. Epidemiology of severe sepsis. Virulence. 2014;5(1):4-11. doi:10.4161/viru.27372
Google Scholar | Crossref | Medline | ISI22. Rudd, KE, Johnson, SC, Agesa, KM, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study. Lancet Lond Engl. 2020;395(10219):200-211. doi:10.1016/S0140-6736(19)32989-7
Google Scholar | Crossref | Medline23. Brun-Buisson, C, Doyon, F, Carlet, J. Bacteremia and severe sepsis in adults: a multicenter prospective survey in ICUs and wards of 24 hospitals. French bacteremia-sepsis study group. Am J Respir Crit Care Med. 1996;154(3 Pt 1):617-624. doi:10.1164/ajrccm.154.3.8810595
Google Scholar | Crossref | Medline24. Sievert, DM, Ricks, P, Edwards, JR, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the national healthcare safety network at the centers for disease control and prevention, 2009-2010. Infect Control Hosp Epidemiol. 2013;34(1):1-14. doi:10.1086/668770
Google Scholar | Crossref | Medline | ISI25. Hidron, AI, Edwards, JR, Patel, J, et al. NHSN Annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the national healthcare safety network at the centers for disease control and prevention, 2006-2007. Infect Control Hosp Epidemiol. 2008;29(11):996-1011. doi:10.1086/591861
Google Scholar | Crossref | Medline | ISI26. Albrecht, SJ, Fishman, NO, Kitchen, J, et al. Reemergence of gram-negative health care-associated bloodstream infections. Arch Intern Med. 2006;166(12):1289-1294. doi:10.1001/archinte.166.12.1289
Google Scholar | Crossref | Medline27. Maschmeyer, G, Haas, A, Cornely, OA. Invasive aspergillosis: epidemiology, diagnosis and management in immunocompromised patients. Drugs. 2007;67(11):1567-1601. doi:10.2165/00003495-200767110-00004
Google Scholar | Crossref | Medline | ISI28. Pittet, D, Wenzel, RP. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med. 1995;155(11):1177-1184. doi:10.1001/archinte.155.11.1177
Google Scholar | Crossref | Medline29. Cleveland, AA, Harrison, LH, Farley, MM, et al. Declining incidence of candidemia and the shifting epidemiology of Candida resistance in two US metropolitan areas, 2008-2013: results from population-based surveillance. PLoS One. 2015;10(3):e0120452. doi:10.1371/journal.pone.0120452
Google Scholar | Crossref | Medline30. Nguyen, MH, Peacock, JE, Morris, AJ, et al. The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance. Am J Med. 1996;100(6):617-623. doi:10.1016/s0002-9343(95)00010-0
Google Scholar | Crossref | Medline | ISI31. Martin, GS . Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther. 2012;10(6):701-706. doi:10.1586/eri.12.50
Google Scholar | Crossref | Medline | ISI32. Lassmann, B, Gustafson, DR, Wood, CM, Rosenblatt, JE. Reemergence of anaerobic bacteremia. Clin Infect Dis Off Publ Infect Dis Soc Am. 2007;44(7):895-900. doi:10.1086/512197
Google Scholar | Crossref | Medline33. Leibovici, L . Bacteraemia in the very old. Features and treatment. Drugs Aging. 1995;6(6):456-464. doi:10.2165/00002512-199506060-00005
Google Scholar | Crossref | Medline34. Fenner, L, Widmer, AF, Straub, C, Frei, R. Is the incidence of anaerobic bacteremia decreasing? Analysis of 114 000 blood cultures over a ten-year period. J Clin Microbiol. 2008;46(7):2432-2434. doi:10.1128/JCM.00013-08
Google Scholar | Crossref | Medline35. Brook, I, Frazier, EH. Aerobic and anaerobic infection associated with malignancy. Support Care Cancer Off J Multinatl Assoc Support Care Cancer. 1998;6(2):125-131. doi:10.1007/s005200050146
Google Scholar | Crossref | Medline36. Lark, RL, McNeil, SA, VanderHyde, K, Noorani, Z, Uberti, J, Chenoweth, C. Risk factors for anaerobic bloodstream infections in bone marrow transplant recipients. Clin Infect Dis Off Publ Infect Dis Soc Am. 2001;33(3):338-343. doi:10.1086/322595
Google Scholar | Crossref | Medline37. Tonneau, M, Elkrief, A, Pasquier, D, et al. The role of the gut microbiome on radiation therapy efficacy and gastrointestinal complications: a systematic review. Radiother Oncol J Eur Soc Ther Radiol Oncol. 2021;156(3):1-9. doi:10.1016/j.radonc.2020.10.033
Google Scholar | Crossref | Medline38. Deen, J, von Seidlein, L, Andersen, F, Elle, N, White, NJ, Lubell, Y. Community-acquired bacterial bloodstream infections in developing countries in south and Southeast Asia: a systematic review. Lancet Infect Dis. 2012;12(6):480-487. doi:10.1016/S1473-3099(12)70028-2
Google Scholar | Crossref | Medline39. Mughini-Gras, L, Pijnacker, R, Duijster, J, et al. Changing epidemiology of invasive non-typhoid Salmonella infection: a nationwide population-based registry study. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2020;26(7):941.e9-941.e14. doi:10.1016/j.cmi.2019.11.015
Google Scholar | Crossref40. Wang, X, Biswas, S, Paudyal, N, et al. Corrigendum: antibiotic resistance in Salmonella Typhimurium isolates recovered from the food chain through national antimicrobial resistance monitoring system between 1996 and 2016. Front Microbiol. 2020;11:1738. doi:10.3389/fmicb.2020.01738
Google Scholar | Crossref | Medline41. Karlowsky, JA, Walkty, AJ, Adam, HJ, Baxter, MR, Hoban, DJ, Zhanel, GG. Prevalence of antimicrobial resistance among clinical isolates of Bacteroides fragilis group in Canada in 2010-2011: CANWARD surveillance study. Antimicrob Agents Chemother. 2012;56(3):1247-1252. doi:10.1128/AAC.05823-11
Google Scholar | Crossref | Medline42. Pneumococcal Disease Surveillance Reporting and Trends | CDC. Published April 7, 2021. Accessed July 11, 2021. https://www.cdc.gov/pneumococcal/surveillance.html
Google Scholar43. Wagenvoort, GHJ, Knol, MJ, de Melker, HE, et al. Risk and outcomes of invasive pneumococcal