Neurodegenerative Diseases
Marotta J. · Piano C. · BRUNETTI V. · Genovese D. · Bentivoglio A.R. · Calabresi P. · Cortelli P. · Della Marca G.Log in to MyKarger to check if you already have access to this content.
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Article / Publication Details AbstractIntroduction Autonomic dysfunction has been reported as one of non-motor manifestations of both pre-symptomatic and manifest Huntington’s Disease (HD). The aim of our study was to evaluate heart rate variability (HRV) during wake and sleep in a cohort of patients with manifest HD. Methods Thirty consecutive patients with manifest HD were enrolled, 14 men and 16 women, mean age 57.3±12.2 years. All patients underwent full-night attended video-polysomnography. HRV was analyzed during wake, NREM and REM sleep, in time and frequency domain. Results were compared with a control group of healthy volunteers matched for age and sex. Results During wake HD patients presented significantly higher mean heart rate than controls (72.4±9.6 vs 58.1±7.3 bpm; p
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