Coronavirus disease 2019 (COVID-19), as a new infectious disease, has spread worldwide. COVID-19 mainly impacts respiratory system, but digestive manifestations have been frequently described in COVID-19 cases as well, even as the initial symptoms. And there have been several reports about the different gastrointestinal (GI) manifestations in mild and severe patients or in remission stages. So it is reasonable to consult that GI symptoms have distinct characteristics in different periods of COVID-19. Therefore, this review article will try to summarize the gastrointestinal manifestations and possible mechanisms of COVID-19 in different periods, and explain the significance of gastrointestinal manifestations in systemic inflammatory injury.

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