STING/NF-κB/IL-6-Mediated Inflammation in Microglia Contributes to Spared Nerve Injury (SNI)-Induced Pain Initiation

Abdullah A, Zhang M, Frugier T, Bedoui S, Taylor JM, Crack PJ (2018) STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury. J Neuroinflammation 15:323

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ahn J, Gutman D, Saijo S, Barber GN (2012) STING manifests self DNA-dependent inflammatory disease. Proceedings of the National Academy of Sciences of the United States of America

Baral P, Udit S, Chiu IM (2019) Pain and immunity: implications for host defence. Nat Rev Immunol

Barker RN, Erwig LP, Pearce WP, Devine A, Rees AJ (1999) Differential Effects of Necrotic or Apoptotic Cell Uptake on Antigen Presentation by Macrophages. Pathobiology 67:302–305

CAS  PubMed  Article  PubMed Central  Google Scholar 

Barragan-Iglesias P, Franco-Enzastiga U, Jeevakumar V, Shiers S, Wangzhou A, Granados-Soto V, Campbell ZT, Dussor G, Price TJ (2020) Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain. J Neurosci 40:3517–3532

CAS  PubMed  PubMed Central  Article  Google Scholar 

Bauer S (2006) Toll-erating self DNA. Nat Immunol 7:13–15

CAS  PubMed  Article  PubMed Central  Google Scholar 

Beutler B (2009) Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunol Rev 227

Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57–69

CAS  PubMed  Article  PubMed Central  Google Scholar 

Burdette DL, Vance RE (2013) STING and the innate immune response to nucleic acids in the cytosol. Nat Immunol 14:19–26

CAS  PubMed  Article  PubMed Central  Google Scholar 

Cao F, Gao F, Xu AJ, Chen ZJ, Chen SS, Yang H, Yu HH, Mei W, Liu XJ, Xiao XP et al (2010) Regulation of spinal neuroimmune responses by prolonged morphine treatment in a rat model of cancer induced bone pain. Brain Res 1326:162–173

CAS  PubMed  Article  PubMed Central  Google Scholar 

Chamilos G, Gregorio J, Meller S, Lande R, Kontoyiannis DP, Modlin RL, Gilliet M (2012) Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37. Blood 120:3699

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chang HH, Miaw SC, Tseng W, Sun YW, Liu CC, Tsao HW, Ho IC (2013) PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium-Induced Colitis. J Immunol

Chen G, Zhang YQ, Qadri YJ, Serhan CN, Ji RR (2018a) Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain. Neuron 100:1292–1311

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chen Q, Sun L, Chen ZJ (2016) Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat Immunol 17:1142–1149

CAS  PubMed  Article  Google Scholar 

Chen SP, Sun J, Zhou YQ, Cao F, Braun C, Luo F, Ye DW, Tian YK (2018b) Sinomenine attenuates cancer-induced bone pain via suppressing microglial JAK2/STAT3 and neuronal CAMKII/CREB cascades in rat models. Mol Pain 14:1744806918793232

CAS  PubMed  PubMed Central  Google Scholar 

Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149–158

PubMed  Article  Google Scholar 

Deleo JA, Colburn RW, Nichols M, Malhotra A (1996) Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. Journal of Interferon & Cytokine Research the Official Journal of the International Society for Interferon & Cytokine Research 16:695–700

CAS  Article  Google Scholar 

Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T et al (2014) STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. Immunity 41:843–852

CAS  PubMed  PubMed Central  Article  Google Scholar 

Dominguez E, Mauborgne A, Mallet J, Desclaux M, Pohl M (2010) SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J Neurosci

Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M (2008) JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat. J Neurochem 107:50–60

CAS  PubMed  Article  PubMed Central  Google Scholar 

Donnelly CR, Jiang C, Andriessen AS, Wang K, Wang Z, Ding H, Zhao J, Luo X, Lee MS, Lei YL et al (2021) STING controls nociception via type I interferon signalling in sensory neurons. Nature

Dunphy G, Flannery SM, Almine JF, Connolly DJ, Paulus C, Jonsson KL, Jakobsen MR, Nevels MM, Bowie AG, Unterholzner L (2018) Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-kappaB Signaling after Nuclear DNA Damage. Mol Cell 71:745–760 e745

Fairbanks CA (2003) Spinal delivery of analgesics in experimental models of pain and analgesia. Adv Drug Deliv Rev 55:1007–1041

CAS  PubMed  Article  PubMed Central  Google Scholar 

Grace PM, Rolan PE, Hutchinson MR (2011) Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behav Immun 25:1322–1332

CAS  PubMed  Article  PubMed Central  Google Scholar 

Haag SM, Gulen MF, Reymond L, Gibelin A, Abrami L, Decout A, Heymann M, van der Goot FG, Turcatti G, Behrendt R, Ablasser A (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559:269–273

CAS  PubMed  Article  PubMed Central  Google Scholar 

Hilkens CM, Schlaak JF, Kerr IM (2003) Differential responses to IFN-alpha subtypes in human T cells and dendritic cells. J Immunol 171:5255–5263

CAS  PubMed  Article  PubMed Central  Google Scholar 

Hou Y, Liang H, Rao E, Zheng W, Huang X, Deng L, Zhang Y, Yu X, Xu M, Mauceri H et al (2018) Non-canonical NF-kappaB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy. Immunity 49:490–503 e494

Hornung V, Latz E (2010) Intracellular DNA recognition. Nat Rev Immunol 10:123–130

CAS  PubMed  Article  PubMed Central  Google Scholar 

Hunter MM, Wang A, Parhar KS, Johnston MJG, Rooijen NV, Beck PL, Mckay DM (2010) In Vitro-Derived Alternatively Activated Macrophages Reduce Colonic Inflammation in Mice. Gastroenterology 138:1395–1405

CAS  PubMed  Article  PubMed Central  Google Scholar 

Inoue K, Tsuda M (2018) Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 19:138–152

CAS  PubMed  Article  PubMed Central  Google Scholar 

Jensen TS, Baron R, Haanpää M, Kalso E, Loeser JD, Rice AS, Treede RD (2011) A new definition of neuropathic pain. Pain 152:2204–2205

PubMed  Article  PubMed Central  Google Scholar 

Jiang X, Liu G, Hu Z, Chen G, Chen J, Lv Z (2019) cGAMP inhibits tumor growth in colorectal cancer metastasis through the STING/STAT3 axis in a zebrafish xenograft model. Fish Shellfish Immunol 95:220–226

CAS  PubMed  Article  PubMed Central  Google Scholar 

Kawai T, Akira S (2009) The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol

Kawasaki Y, Zhang L, Cheng JK, Ji RR (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28:5189–5194

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kim D, You B, Jo EK, Han SK, Simon MI, Lee SJ (2010) NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A 107:14851–14856

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K (2013) Minocycline selectively inhibits M1 polarization of microglia. Cell Death Dis 4:e525

Larner AC, Chaudhuri A, Darnell JE Jr (1986) Transcriptional induction by interferon. New protein (s) determine the extent and length of the induction. J Biol Chem 261:453–459

CAS  PubMed  Article  PubMed Central  Google Scholar 

Le WD, Rowe D, Xie WJ, Ortiz I, Appel SH (2001) Microglial Activation and Dopaminergic Cell Injury: An In Vitro Model Relevant to Parkinson’s Disease. The Journal of Neuroence: the Official Journal of the Society for Neuroence 21:8447–8455

CAS  Google Scholar 

Li N, Zhou H, Wu H, Wu Q, Duan M, Deng W, Tang Q (2019) STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3. Redox Biol 24:101215

Li T, Chen ZJ (2018) The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. J Exp Med 215:1287–1299

CAS  PubMed  PubMed Central  Article  Google Scholar 

Li T, Liu T, Chen X, Li L, Feng M, Zhang Y, Wan L, Zhang C, Yao W (2020) Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain. J Neuroinflammation 17:211

CAS  PubMed  PubMed Central  Article  Google Scholar 

Liu S, Karaganis S, Mo RF, Li XX, Wen RX, Song XJ (2020) IFNbeta Treatment Inhibits Nerve Injury-induced Mechanical Allodynia and MAPK Signaling By Activating ISG15 in Mouse Spinal Cord. J Pain 21:836–847

PubMed  Article  PubMed Central  Google Scholar 

Luo W, Wang Y, Zhang L, Ren P, Shen YH (2020) Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture. Circulation 141:42–66

CAS  PubMed  Article  PubMed Central  Google Scholar 

Mathur V, Burai R, Vest RT, Bonanno LN, Lehallier B, Zardeneta ME, Mistry KN, Do D, Marsh SE, Abud EM et al (2017) Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation. Neuron 96:1290–1302 e1296

Mc A, Jmd A, Ddlba B (2012) The role of the immune system in the generation of neuropathic pain - ScienceDirect. Lancet Neurol 11:629–642

Article  CAS  Google Scholar 

Möser C, Kynast K, Baatz K, Russe OQ, Niederberger E (2011) The Protein Kinase IKKε Is a Potential Target for the Treatment of Inflammatory Hyperalgesia. J Immunol 187:2617

PubMed  Article  PubMed Central  Google Scholar 

Moser CV, Stephan H, Altenrath K, Kynast KL, Russe OQ, Olbrich K, Geisslinger G, Niederberger E (2015) TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-kappaB dependent genes. J Neuroinflammation 12:100

留言 (0)

沒有登入
gif