A narrative synthesis of research with 5-MeO-DMT

Abramson, HA, Gettner, HH, Carone, PA, et al. (1979) The intracranial injection of drugs in goldfish – I: Hallucinogens and their antagonism to smooth muscle activity. Journal of Asthma Research 16(2): 55–61.
Google Scholar | Crossref | Medline Acosta-Urquidi, J (2015) QEEG studies of the acute effects of the visionary tryptamine DMT. Cosmos and History: The Journal of Natural and Social Philosophy 11(2): 115–129.
Google Scholar Adrien, J, Lanfumey, L (1986) Ontogenesis of unit activity in the raphe dorsalis of the behaving kitten: Its relationship with the states of vigilance. Brain Research 366(1–2): 10–21.
Google Scholar | Crossref | Medline Agurell, S, Holmstedt, B, Lindgren, JE (1969) Metabolism of 5-methoxy-N,N dimethyltryptamine-14C in the rat. Biochemical Pharmacology 18(12): 2771–2781.
Google Scholar | Crossref | Medline Ahlborg, U, Holmstedt, B, Lindgren, JE (1968) Fate and metabolism of some hallucinogenic indolealkylamines. Advances in Pharmacology 6(Pt. B): 213–229.
Google Scholar | Crossref | Medline Ahlenius, S, Larsson, K (1991) Opposite effects of 5-methoxy-N, N-di-methyl-tryptamine and 5-hydroxytryptophan on male rat sexual behavior. Pharmacology, Biochemistry, and Behavior 38(1): 201–205.
Google Scholar | Crossref | Medline Archer, T, Ogren, SO, Ross, SB (1982) Serotonin involvement in aversive conditioning: Reversal of the fear retention deficit by long-term p-chloroamphetamine but not p-chlorophenylalanine. Neuroscience Letters 34(1): 75–82.
Google Scholar | Crossref | Medline Barbeau, H, Rossignol, S (1990) The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat. Brain Research 514(1): 55–67.
Google Scholar | Crossref | Medline Barker, SA, Littlefield-Chabaud, MA, David, C (2001) Distribution of the hallucinogens N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine in rat brain following intraperitoneal injection: Application of a new solid-phase extraction LC–APcI–MS–MS–isotope dilution method. Journal of Chromatography B: Biomedical Sciences and Applications 751(1): 37–47.
Google Scholar | Crossref | Medline Barker, SA, McIlhenny, EH, Strassman, R (2012) A critical review of reports of endogenous psychedelic N, N-dimethyltryptamines in humans: 1955-2010. Drug Testing and Analysis 4(7–8): 617–635.
Google Scholar | Crossref | Medline | ISI Barrett, FS, Bradstreet, MP, Leoutsakos, J-MS, et al. (2016) The Challenging Experience Questionnaire: Characterization of challenging experiences with psilocybin mushrooms. Journal of Psychopharmacology 30(12): 1279–1295.
Google Scholar | SAGE Journals | ISI Barrett, FS, Johnson, MW, Griffiths, RR (2015) Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin. Journal of Psychopharmacology 29(11): 1182–1190.
Google Scholar | SAGE Journals | ISI Barsuglia, J, Davis, AK, Palmer, R, et al. (2018) Intensity of mystical experiences occasioned by 5-MeO-DMT and comparison with a prior psilocybin study. Frontiers in Psychology 9: 2459.
Google Scholar | Crossref | Medline Barsuglia, JP, Polanco, M, Palmer, R, et al. (2018) A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder. Progress in Brain Research 242: 121–158.
Google Scholar | Crossref | Medline Beaton, JM, Morris, PE (1984) Ontogeny of N, N-dimethyltryptamine and related indolealkylamine levels in neonatal rats. Mechanisms of Ageing and Development 25(3): 343–347.
Google Scholar | Crossref | Medline Bedard, P, Pycock, CJ (1977) ‘Wet-dog’ shake behaviour in the rat: A possible quantitative model of central 5-hydroxytryptamine activity. Neuropharmacology 16(10): 663–670.
Google Scholar | Crossref | Medline Benington, F, Morin, RD, Clark, LC (1965) 5-methoxy-N, N-dimethyltryptamine, a possible endogenous psychotoxin. The Alabama Journal of Medical Sciences 2(4): 397–403.
Google Scholar | Medline Berendsen, HHG, Jenck, F, Broekkamp, CLE (1989) Selective activation of 5HT1A receptors induces lower lip retraction in the rat. Pharmacology, Biochemistry, and Behavior 33(4): 821–827.
Google Scholar | Crossref | Medline Berge, O, Chacho, D, Hole, K (1983) Inhibitory effect of 5-methoxy-N,N-dimethyltryptamine on the synaptosomal uptake of 5-hydroxytryptamine. European Journal of Pharmacology 90(2–3): 293–296.
Google Scholar | Crossref | Medline Berge, O-G (1982) Effects of 5-HT receptor agonists and antagonists on a reflex response to radiant heat in normal and spinally transected rats. Pain 13(3): 253–266.
Google Scholar | Crossref | Medline Berge, O-G, Hole, K, Dahle, H (1980) Nociception is enhanced after low doses and reduced after high doses of the serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine. Neuroscience Letters 19(2): 219–223.
Google Scholar | Crossref | Medline Berger, G, Mazière, M, Marazano, C, et al. (1978) Carbon-11 labeling of the psychoactive drug O-methyl-bufotenine and its distribution in the animal organism. European Journal of Nuclear Medicine 3(2): 101–104.
Google Scholar | Crossref | Medline Blough, BE, Landavazo, A, Decker, AM, et al. (2014) Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes. Psychopharmacology 231(21): 4135–4144.
Google Scholar | Crossref | Medline Bogenschutz, MP, Forcehimes, AA, Pommy, JA, et al. (2015) Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study. Journal of Psychopharmacology 29(3): 289–299.
Google Scholar | SAGE Journals | ISI Bogenschutz, MP, Podrebarac, SK, Duane, JH, et al. (2018) Clinical interpretations of patient experience in a trial of psilocybin-assisted psychotherapy for alcohol use disorder. Frontiers in Pharmacology 9: 100.
Google Scholar | Crossref | Medline Bourke, C, Carrigan, M, Dixon, R (1988) Experimental evidence that tryptamine alkaloids do not cause Phalaris aquatica sudden death syndrome in sheep. Australian Veterinary Journal 65(7): 218–220.
Google Scholar | Crossref | Medline Bourke, C, Carrigan, M, Dixon, R (1990) The pathogenesis of the nervous syndrome of Phalaris aquatica toxicity in sheep. Australian Veterinary Journal 67(10): 356–358.
Google Scholar Bruno, R, Matthews, AJ, Dunn, M, et al. (2012) Emerging psychoactive substance use among regular ecstasy users in Australia. Drug and Alcohol Dependence 124(1–2): 19–25.
Google Scholar | Crossref | Medline Brush, DE, Bird, SB, Boyer, EW (2004) Monoamine oxidase inhibitor poisoning resulting from internet misinformation on illicit substances. Journal of Toxicology: Clinical Toxicology 42(2): 191–195.
Google Scholar | Crossref | Medline Canada Justice Laws (1996) Consolidated Federal Laws of Canada, Controlled Drugs and Substances Act (S.C. 1996, c. 19). Available at: https://laws-lois.justice.gc.ca/eng/acts/C-38.8/ (accessed 26 February 2021).
Google Scholar Canal, CE, Murnane, KS (2017) The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens. Journal of Psychopharmacology 31(1): 127–143.
Google Scholar | SAGE Journals | ISI Carhart-Harris, RL, Nutt, DJ (2010) User perceptions of the benefits and harms of hallucinogenic drug use: A web-based questionnaire study. Journal of Substance Use 15(4): 283–300.
Google Scholar | Crossref Carhart-Harris, RL, Bolstridge, M, Day, CMJ, et al. (2018) Psilocybin with psychological support for treatment-resistant depression: Six-month follow-up. Psychopharmacology 235(2): 399–408.
Google Scholar | Crossref | Medline Carhart-Harris, RL, Bolstridge, M, Rucker, J, et al. (2016) Psilocybin with psychological support for treatment-resistant depression: An open-label feasibility study. The Lancet Psychiatry 3(7): 619–627.
Google Scholar | Crossref | Medline Carlsson, M, Eriksson, E (1986) A central serotonin receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, has different effects on prolactin secretion in male and female rats. Acta Pharmacologica et Toxicologica 58(4): 297–302.
Google Scholar | Crossref | Medline Castellanos, JP, Woolley, C, Bruno, KA, et al. (2020) Chronic pain and psychedelics: A review and proposed mechanism of action. Regional Anesthesia & Pain Medicine 45(7): 486–494.
Google Scholar | Crossref | Medline Cazala, P, Garrigues, AM (1983) Effects of apomorphine, clonidine or 5-methoxy-NN-dimethyltryptamine on approach and escape components of lateral hypothalamic and mesencephalic central gray stimulation in two inbred strains of mice. Pharmacology, Biochemistry, and Behavior 18(1): 87–93.
Google Scholar | Crossref | Medline Christian, ST, Benington, F, Morin, RD, et al. (1975) Gas-liquid chromatographic separation and identification of biologically important indolealkylamines from human cerebrospinal fluid. Biochemical Medicine 14(2): 191–200.
Google Scholar | Crossref | Medline Clinicaltrials.gov (2019) Safety of GH001 in Healthy Volunteers (ClinicalTrials.gov Identifier: NCT 04640831). Bethesda, MD: National Library of Medicine. Available at: https://clinicaltrials.gov/ct2/show/NCT04640831 (accessed 16 August 2021).
Google Scholar Clinicaltrials.gov (2021a) ClinicalTrials.gov Identifier: NCT 04698603 Clinical Study of GH001 in Depression. Bethesda, MD: National Library of Medicine. Available at: https://clinicaltrials.gov/ct2/show/NCT04698603 (accessed 16 August 2021).
Google Scholar Clinicaltrials.gov (2021b) ClinicalTrials.gov Identifier: NCT 05032833 Single Ascending Dose Study with 5-MeO-DMT in Healthy Subjects. Bethesda, MD: National Library of Medicine. Available at: https://clinicaltrials.gov/ct2/show/NCT05032833 (accessed 3 September 2021).
Google Scholar Corbett, L, Christian, ST, Morin, RD, et al. (1978) Hallucinogenic N-methylated indolealkylamines in the cerebrospinal fluid of psychiatric and control populations. The British Journal of Psychiatry 132: 139–144.
Google Scholar | Crossref | Medline Critchley, MAE, Handley, SL (1987) Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors. Psychopharmacology 93(4): 7243.
Google Scholar | Crossref Dabiré, H (1991) Central 5-hydroxytryptamine (5-HT) receptors in blood pressure regulation. Therapie 46(6): 421–429.
Google Scholar | Medline Dabiré, H, Cherqui, C, Fournier, B, et al. (1987) Comparison of effects of some 5-HT1 agonists on blood pressure and heart rate of normotensive anaesthetized rats. European Journal of Pharmacology 140(3): 259–266.
Google Scholar | Crossref | Medline Dakic, V, Minardi Nascimento, J, Costa Sartore, R, et al. (2017) Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT. Scientific Reports 7(1): 12779.
Google Scholar | Crossref | Medline Danysz, W, Minor, BG, Post, C, et al. (1986) Chronic treatment with antidepressant drugs and the analgesia induced by 5-methoxy-N, N-dimethyltryptamine: Attenuation by desipramine. Acta Pharmacologica et Toxicologica 59(2): 103–112.
Google Scholar | Crossref | Medline Davis, AK, Averill, LA, Sepeda, ND, et al. (2020) Psychedelic treatment for trauma-related psychological and cognitive impairment among US special operations forces veterans. Chronic Stress 4: 93956.
Google Scholar | SAGE Journals Davis, AK, Barsuglia, JP, Lancelotta, R, et al. (2018) The epidemiology of 5-methoxy-N, N-Dimethyltryptamine (use Benefits consequences patterns of use subjective effects and reasons for consumption). Journal of Psychopharmacology 32(7): 779–792.
Google Scholar | SAGE Journals | ISI Davis, AK, So, S, Lancelotta, R, et al. (2019) 5-methoxy-N, N-dimethyltryptamine (used in a naturalistic group setting is associated with unintended improvements in depression and anxiety). The American Journal of Drug and Alcohol Abuse 45(2): 161–169.
Google Scholar | Crossref | Medline Derogatis, LR (2001) Brief Symptom Inventory 18: Administration, Scoring and Procedures Manual. NCS Pearson. Available at: https://www.pearsonassessments.com/store/usassessments/en/Store/Professional-Assessments/Personality-%26-Biopsychosocial/Brief-Symptom-Inventory-18/p/100000638.html (accessed 11 March 2021).
Google Scholar Dickinson, SL, Curzon, G (

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