Sonoporation‐Enhanced Delivery of STING Agonist Induced Robust Immune Modulation and Tumor Regression (Adv. Therap. 10/2021)

In article number 2100154, Jun Xu, Adam Procopio, and co-workers have demonstrated a 5 min clinically translatable sonoporation procedure using FDA-approved microbubbles and commercially available diagnostic ultrasound enabled the systemic delivery of CDN-based STING agonist MSA-1 and regressed both unilaterally and bilaterally inoculated syngeneic tumors as a result of improved PK/PD and immune modulation. image

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