Nussbaum S.R. Carter M.J. Fife C.E. et al.

An economic evaluation of the impact, cost, and medicare policy implications of chronic nonhealing wounds.

Value Health. 21: 27-32

Chronic wound healing: a review of current management and treatments.

Adv Ther. 34: 599-610Smiell J.M. Wieman T.J. Steed D.L. Perry B.H. Sampson A.R. Schwab B.H.

Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with nonhealing, lower extremity diabetic ulcers: a combined analysis of four randomized studies.

Wound Repair Regen. 7: 335-346Harrison S. Vavken P. Kevy S. Jacobson M. Zurakowski D. Murray M.M.

Platelet activation by collagen provides sustained release of anabolic cytokines.

Am J Sports Med. 39: 729-734Strandberg G. Sellberg F. Sommar P. et al.

Standardizing the freeze-thaw preparation of growth factors from platelet lysate.

Transfusion. 57: 1058-1065Landesberg R. Burke A. Pinsky D. et al.

Activation of platelet-rich plasma using thrombin receptor agonist peptide.

J Oral Maxillofac Surg. 63: 529-535Drago L. Bortolin M. Vassena C. Taschieri S. Del Fabbro M.

Antimicrobial activity of pure platelet-rich plasma against microorganisms isolated from oral cavity.

BMC Microbiol. 13: 47Cieslik-Bielecka A. Bielecki T. Gazdzik T.S. Arendt J. Król W. Szczepanski T.

Autologous platelets and leukocytes can improve healing of infected high-energy soft tissue injury.

Transfus Apher Sci. 41: 9-12Chadwick P. Edmonds M. McCardle J. Armstrong D.

Best practice guidelines: Wound management in diabetic foot ulcers.

Wounds Int. 5: 27Lavery L.A. Davis K.E. Berriman S.J. et al.

WHS guidelines update: diabetic foot ulcer treatment guidelines.

Wound Repair Regen. 24: 112-126National Institute for Health and Care Excellence

Diabetic foot problems: prevention and management.

Gould L. Stuntz M. Giovannelli M. et al.

Wound Healing Society 2015 update on guidelines for pressure ulcers.

Wound Repair Regen. 24: 145

Prevention and Treatment of Pressure Ulcers/Injuries: Clinical Practice Guideline The International Guideline.

Elraiyah T. Tsapas A. Prutsky G. et al.

A systematic review and meta-analysis of adjunctive therapies in diabetic foot ulcers.

J Vasc Sug. 63: 46S-58S.e41-58S.e42Game F. Jeffcoate W. Tarnow L. et al.

LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial.

Lancet Diabetes Endocrinol. 6: 870-878Yang L. Gao L. Lv Y. Wang J.

Autologous platelet-rich gel for lower-extremity ischemic ulcers in patients with type 2 diabetes.

Int J Clin Exp Med. 10: 13796-13801Driver V.R. Hanft J. Fylling C.P. Beriou J.M. Autologel Diabetic Foot Ulcer Study Gruop

A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers.

Ostomy Wound Manage. 52 (): 68-70Burgos-Alonso N. Lobato I. Hernandez I. et al.

Autologous platelet-rich plasma in the treatment of venous leg ulcers in primary care: a randomised controlled, pilot study.

J Wound Care. 27: S20-S24Serra R. Grande R. Butrico L. et al.

Skin grafting and topical application of platelet gel in the treatment of vascular lower extremity ulcers.

Acta Phlebologica. 15: 129-136Moher D. Liberati A. Tetzlaff J. Altman D.G.

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

BMJ. 339: b2535Sterne J.A.C. Savovic J. Page M.J. et al.

RoB 2: a revised tool for assessing risk of bias in randomised trials.

BMJ. 366: l4898Wells G. Shea B. O’Connell D. et al.

The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. In: 2000.

Rover C. Knapp G. Friede T.

Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies.

BMC Med Res Methodol. 15: 99US Department of Health and Human Services. Agency for Healthcare Research and Quality, ed. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality, Rockville, MDLi L. Chen D. Wang C. et al.

Autologous platelet-rich gel for treatment of diabetic chronic refractory cutaneous ulcers: a prospective, randomized clinical trial.

Wound Repair Regen. 23: 495-505Gude W. Hagan D. Abood F. Clausen P.

Aurix gel is an effective intervention for chronic diabetic foot ulcers: a pragmatic randomized controlled trial.

Adv Skin Wound Care. 32: 416-426Ahmed M. Reffat S.A. Hassan A. Eskander F.

Platelet-rich plasma for the treatment of clean diabetic foot ulcers.

Ann Vasc Surg. 38: 206-211Saad Setta H. Elshahat A. Elsherbiny K. Massoud K. Safe I.

Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study.

Int Wound J. 8: 307-312Saldalamacchia G. Lapice E. Cuomo V. et al.

A controlled study of the use of autologous platelet gel for the treatment of diabetic foot ulcers.

Nutr Metab Cardiovasc Dis. 14: 395-396Karimi R. Afshar M. Salimian M. Sharif A. Hidariyan M.

The effect of platelet rich plasma dressing on healing diabetic foot ulcers.

Nurs Midwifery Stud. 5: e30314Kakagia D.D. Kazakos K.J. Xarchas K.C. et al.

Synergistic action of protease-modulating matrix and autologous growth factors in healing of diabetic foot ulcers. A prospective randomized trial.

J Diabetes Complications. 21: 387-391Singh S.P. Kumar V. Pandey A. Pandey P. Gupta V. Verma R.

Role of platelet-rich plasma in healing diabetic foot ulcers: a prospective study.

J Wound Care. 27: 550-556Elsaid A. El-Said M. Emile S. Youssef M. Khafagy W. Elshobaky A.

Randomized controlled trial on autologous platelet-rich plasma versus saline dressing in treatment of non-healing diabetic foot ulcers.

World J Surg. 44: 1294-1301Xie J. Fang Y. Zhao Y. Cao D. Lv Y.

Autologous platelet-rich gel for the treatment of diabetic sinus tract wounds: a clinical study.

J Surg Res. 247: 271-279Milek T. Baranowski K. Zydlewski P. Ciostek P. Mlosek K. Olszewski W.

Role of plasma growth factor in the healing of chronic ulcers of the lower legs and foot due to ischaemia in diabetic patients.

Postepy Dermatol Alergol. 34: 601-606Glukhov A.A. Aralova M.V.

The study of the effectiveness of the drug combination of collagen and platelet-rich plasma for the regional treatment of venous ulcers.

Res J Pharm Biol Chem Sci. 8: 2258-2263Senet P. Bon F.X. Benbunan M. et al.

Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers.

J Vasc Surg. 38: 1342-1348Escamilla Cardenosa M. Dominguez-Maldonado G. Cordoba-Fernandez A.

Efficacy and safety of the use of platelet-rich plasma to manage venous ulcers.

J Tissue Viability. 26: 138-143Milek T. Nagraba L. Mitek T. et al.

Autologous platelet-rich plasma reduces healing time of chronic venous leg ulcers: a prospective observational study.

Adv Exp Med Biol. 1176: 109-117Etugov D. Mateeva V. Mateev G.

Autologous platelet-rich plasma for treatment of venous leg ulcers: a prospective controlled study.

J Biol Regul Homeost Agents. 32: 593-597Elbarbary A.H. Hassan H.A. Elbendak E.A.

Autologous platelet-rich plasma injection enhances healing of chronic venous leg ulcer: a prospective randomised study.

Int Wound J. 17: 992-1001

Comparison of efficacy of autologous platelet-rich fibrin versus unna's paste dressing in chronic venous leg ulcers: a comparative study.

Indian Dermatol. 11: 58-61Moneib H.A. Youssef S.S. Aly D.G. Rizk M.A. Abdelhakeem Y.I.

Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: a comparative study.

J Cosmet Dermatol. 17: 495-501

Comparison of platelet-rich plasma gel in the care of the pressure ulcers with the dressing with serum physiology in terms of healing process and dressing costs.

Int Wound J. 17: 831-841Singh R. Rohilla R.K. Dhayal R.K. Sen R. Sehgal P.K.

Role of local application of autologous platelet-rich plasma in the management of pressure ulcers in spinal cord injury patients.

Spinal Cord. 52: 809-816

National Health Service. National Diabetes Foot Care Audit, 2014-2018.

()Margolis D.J. Kantor J. Berlin J.A.

Healing of diabetic neuropathic foot ulcers receiving standard treatment. A meta-analysis.

Diabetes Care. 22: 692-695Ndosi M. Wright-Hughes A. Brown S. et al.

Prognosis of the infected diabetic foot ulcer: a 12-month prospective observational study.

Diabet Med. 35: 78-88Sheehan P. Jones P. Caselli A. Giurini J.M. Veves A.

Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial.

Diabetes Care. 26: 1879-1882

Priorities in offloading the diabetic foot.

Diabetes Metab Res Rev. 28: 54-59Meijer J.W.G. Trip J. Jaegers S.M.H.J. et al.

Quality of life in patients with diabetic foot ulcers.

Disability Rehab. 23: 336-340Roth R.S. Lowery J.C. Hamill J.B.

Assessing persistent pain and its relation to affective distress, depressive symptoms, and pain catastrophizing in patients with chronic wounds: a pilot study.

Am J Phys Med Rehabil. 83: 827-834

Centralization phenomenon as a prognostic factor for chronic low back pain and disability.

Spine (Phila Pa 1976. 26: 758-764Lindholm C. Bjellerup M. Christensen O.B. Zederfeldt B.

Quality of life in chronic leg ulcer patients. An assessment according to the Nottingham Health Profile.

Acta Derm Venereol. 73: 440-443Ribu L. Rustoen T. Birkeland K. Hanestad B.R. Paul S.M. Miaskowski C.

The prevalence and occurrence of diabetic foot ulcer pain and its impact on health-related quality of life.

J Pain. 7: 290-299Paschou S.A. Stamou M. Vuagnat H. Tentolouris N. Jude E.

Pain management of chronic wounds: Diabetic ulcers and beyond.

Maturitas. 117: 17-21Volkow N.D. McLellan A.T.

Opioid abuse in chronic pain—misconceptions and mitigation strategies.

N Engl J Med. 374: 1253-1263Mahdavian Delavary B. van der Veer W.M. van Egmond M. Niessen F.B. Beelen R.H.

Macrophages in skin injury and repair.

Immunobiology. 216: 753-762Hofman D. Ryan T.J. Arnold F. et al.

Pain in venous leg ulcers.

J Wound Care. 6: 222-224Vilela L. Salomé G. Pereira R. Ferreira L.

Pain assessment in patients with venous leg ulcer treated by compression therapy with unnas boot.

J Tissue Sci Eng. 7: 2