The Vein Glossary.

J Vasc Surg Venous Lymphat Disord. 6: e11-e217Tatsioni A. Balk E. TFJr O’Donnell Lau J.

Usual care in the management of chronic wounds: a review of the recent literature.

J Am Coll Surg. 205: 617-624Ruckley C.V. Evans C.J. Allan P. Lee A.J. Fowkes G.R.

Chronic venous insufficiency: Clinical and duplex correlations. The Edinburgh Vein Study of venous disorders in the general population.

J Vasc Surg. 36: 520-525Jawien A. Grzela T. Ochwat A.

Prevalence of chronic venous insufficiency in men and women in Poland: Multicenter cross-sectional study in 40,095 patients.

Phlebology. 18: 110Rabe E. Pannier-Fischer F. Bromen K. Schuldt K. Stang A. Poncar C. et al.

Bonner Venenstudie der Deutschen Gesellschaft fu¨r Phlebolo- gieepidemiologische Untersuchung zur Frage der Ha¨ufigkeit und Auspra¨gung von chronischen Venenkrankheiten in der sta¨dtischen und la¨ndlichen Wohnbevo¨lkerung.

Phlebologie. 32: 1-14Margolis D.J. Bilker W. Santanna J. Baumgarten M.

Venous leg ulcer: incidence and prevalence in the elderly.

J Am Acad Dermatol. 46: 381-386

Venous leg ulceration pathophysiology and evidence based treatment.

Vasc Med. 20: 168-181Hopman W.M. VanDenKerkhof E.G. Carley M.E. Kuhnke J.L. Harrison M.B.

Factors associated with health-related quality of life in chronic leg ulceration.

Qual Life Res. 23: 1833-1840Barwell J.R. Davies C.E. Deacon J. Harvey K. Minor J. Sassano A. et al.

Comparison of surgery and compression with compression alone in chronic venous ulceration (ESCHAR study): randomised controlled trial.

Lancet. 363: 1854-1859Gohel M.S. Barwell J.R. Taylor M. Chant T. Foy C. Earnshaw J.J. et al.

Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): Randomized controlled trial.

BMJ. 335: 83Ma H. O’Donnell T.F. Rosen N.A. Iafrati M.D.

The real costs of treating venous ulcers in a contemporary vascular practice.

J Vasc Surg Venous Lymphat Disord. 2: 355-361Rice J.B. Desai U. Cummings A.K. Birnbaum H.G. Skornicki M. Parsons N.

Burden of venous leg ulcers in the United States.

J Med Econ. 17: 347-356O’Donnell T.F. Passman M.A. Marston W.A. Ennis W.J. Dalsing M. Kistner R.L. et al.

Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery ® and the American Venous Forum.

J Vasc Surg. 60: 3S-59SO’Meara S. Cullum N.A. Nelson E.A.

Compression for venous leg ulcers.

Cochrane Database Syst Rev. 1: CD000265Kankam H.K.N. Lim C.S. Fiorentino F. Davies A.H. Gohel M.S.

A summation analysis of compliance and complications of compression hosiery for patients with chronic venous disease or post-thrombotic syndrome.

Eur J Vasc Endovasc Surg. 55: 406e416Moffatt C. Kommala D. Dourdin N. Choe Y.

Venous leg ulcers: patient concordance with compression therapy and its impact on healing and prevention of recurrence.

Int Wound J. 6: 386-393Jull A.B. Arroll B. Parag V. Waters J.

Pentoxifylline for treating venous leg ulcers.

Cochrane Database Syst Rev. 3: CD001733Coleridge-Smith P. Lok C. Ramelet A.A.

Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction.

Eur J Vasc Endovasc Surg. 30: 198-208Scallon C. Bell-Syer S.E.M. Aziz Z.

Flavonoids for treating venous leg ulcers.

Cochrane Database of Systematic Reviews. 5: CD006477Wu B. Lu J. Yang M. Xu T.

Sulodexide for treating venous leg ulcers.

Cochrane Database Syst Rev. 6: CD010694Raffetto J.D. Eberhardt R.T. Dean S.M. Ligi D. Mannello F.

Pharmacologic treatment to improve venous leg ulcer healing.

J Vasc Surg Venous Lymphat Disord. 4: 371-374O’Meara S. Al-Kurdi D. Ologun Y. Ovington L.G. Martyn-St James M. Richardson R. et al.

Antibiotics and antiseptics for venous leg ulcers.

Cochrane Database Syst Rev. 1: CD003557van Gent W.B. Hop W.C. van Praag M.C. Mackaay A.J. de Boer E.M. Wittens C.H.

Conservative versus surgical treatment of venous leg ulcers: a prospective, randomized, multicenter trial.

J Vasc Surg. 44: 563-571Gohel M.S. Heatley F. Liu X. Bradbury A. Bulbulia R. Cullum N. et al.

A randomized trial of early endovenous ablation in venous ulceration.

N Engl J Med. 378: 2105-2114

U.S. Food and Drug Administration website. “[email protected]: FDA-Approved Drugs.” Updated March 22, 2018. Accessed April 22, 2021. https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm.

Marston W. Tang J. Kirsner R.S. Ennis W.

Wound healing society 2015 update on guidelines for venous ulcers.

Wound Rep Reg. 24: 136-144Moher D. Liberati A. Tetzlaff J. Altman D.G. PRISMA Group

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.

PLoS Med. 6e1000097Wilcox J.R. Carter M.J. Covington S.

Frequency of Debridements and Time to Heal: A Retrospective Cohort Study of 312 744 Wounds.

JAMA Dermatol. 149: 1050-1058Trengove N.J. Bielefeldt-Ohmann H. Stacey M.C.

Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers.

Wound Repair Regen. 8: 13-25Ulrich D. Lichtenegger F. Unglaub F. Smeets R. Pallua N.

Effect of chronic wound exudates and MMP-2/-9 inhibitor on angiogenesis in vitro.

Plast Reconstr Surg. 116: 539-545Raffetto J.D. Ligi D. Maniscalco R. Khalil R.A. Mannello F.

Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment.

J Clin Med. 10: 29

World Union of Wound Healing Societies (WUWHS). Principles of best practice: Wound exudate and the role of dressings. A consensus document. London: MEP Ltd, 2007.

Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig.

Nature. 193: 293-294Palfreyman S. Nelson E.A. Michaels J.A.

Dressings for venous leg ulcers: systematic review and meta-analysis.

BMJ. 335: 244Norman G. Westby M.J. Rithalia A.D. Stubbs N. Soares M.O. Dumville J.C. et al.

Dressings and topical agents for treating venous leg ulcers.

Cochrane Database of Systematic Reviews. 6: CD012583

Skin grafting for venous leg ulcers.

Cochrane Database Syst Rev. 2: CD001737Falanga V. Margolis D. Alvarez O. Auletta M. Maggiacomo F. Altman M. et al.

Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent. Human Skin Equivalent Investigators Group.

Arch Dermatol. 134: 293-300Mostow E.N. Haraway G.D. Dalsing M. Hodde J.P. King D. OASIS Venus Ulcer Study Group

Effectiveness of an extracellular matrix graft (OASIS Wound Matrix) in the treatment of chronic leg ulcers: a randomized clinical trial.

J Vasc Surg. 41: 837-843Romanelli M. Dini V. Bertone M.S.

Randomized comparison of OASIS wound matrix versus moist wound dressing in the treatment of difficult-to-heal wounds of mixed arterial/ venous etiology.

Adv Skin Wound Care. 23: 34-38

A randomized controlled trial comparing a human acellular dermal matrix versus conventional care for the treatment of venous leg ulcers.

Wounds. 31: 68-74Carter M.J. Waycaster C. Schaum K. Gilligan A.M.

Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers.

Value Health. 17: 801-813Da Costa R.M. Ribeiro Jesus F.M. Aniceto C. Mendes M.

Randomized, double-blind, placebo-controlled, dose- ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers.

Wound Repair Regen. 7: 17-25Da Costa R.M. Jesus F.M. Aniceto C. Mendes M.

Double-blind randomized placebo-controlled trial of the use of granulocyte-macrophage colony-stimulating factor in chronic leg ulcers.

Am J Surg. 173: 165-168

The healing properties of Promogran in venous leg ulcers.

J Wound Care. 11: 335-341

Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;366:I4898.

Kasenda B. von Elm E. You J.J. Blümle A. Tomonaga Y. Saccilotto R.

Agreements between industry and academia on publication rights: a retrospective study of protocols and publications of randomized clinical trials.

PLoS Med. 13e1002046Eaglstein W.H. Mertz P.M.

“Inert” vehicles do affect wound healing.

J Invest Dermatol. 74: 90-91Marston W.A. Crowner J. Kouri A. Kalbaugh C.A.

Incidence of venous leg ulcer healing and recurrence after treatment with endovenous laser ablation.

JVS. 5: 525-532Harlander-Locke M. Lawrence P.F. Alktaifi A. Jimenez J.C. Rigberg D. DeRubertis B.

The impact of ablation of incompetent superficial and perforator veins on ulcer healing rates.

J Vasc Surg. 55: 458-464Margolis D.J. Allen-Taylor L. Hoffstad O. Berlin J.A.

The accuracy of venous leg ulcer prognostic models in a wound care system.

Wound Repair and Regeneration. 12: 163‐8Cardinal M. Eisenbud D.E. Phillips T. Harding K.

Early healing rates and wound area measurements are reliable predictors of later complete wound closure.

Wound Repair Regen. 16: 19-22

The Wound Healing Index for Predicting Venous Leg Ulcer Outcome.

Adv Wound Care (New Rochelle). 9: 68-77Takeuchi Y. Ueno K. Mizoguchi T. Samura M. Harada T. Oga A. et al.

Development of Novel Mouse Model of Ulcers Induced by Implantation of Magnets.

Sci Rep. 7: 4843