Voltage-Gated Sodium Channel β1 Gene: An Overview

Al-Ward H.a· Liu C.-Y.b· Liu N.a· Shaher F.c· Al-Nusaif M.d· Mao J.a· Xu H.a

Author affiliations

aDepartment of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China
bDepartment of Biochemistry and Molecular Biology, Ankang University School of Medicine, Ankang, China
cDepartment of Pathophysiology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China
dDepartment of Neurology, Dalian Medical University, Dalian, China

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Article / Publication Details

First-Page Preview

Abstract of Review

Received: February 10, 2021
Accepted: April 01, 2021
Published online: May 26, 2021

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE

Abstract

Background: Voltage-gated sodium channels are protein complexes composed of 2 subunits, namely, pore-forming α- and regulatory β-subunits. A β-subunit consists of 5 proteins encoded by 4 genes (i.e., SCN1B–SCN4B). Summary: β1-Subunits regulate sodium ion channel functions, including gating properties, subcellular localization, and kinetics. Key Message: Sodium channel β1- and its variant β1B-subunits are encoded by SCN1B. These variants are associated with many human diseases, such as epilepsy, Brugada syndrome, Dravet syndrome, and cancers. On the basis of previous research, we aimed to provide an overview of the structure, expression, and involvement of SCN1B in physiological processes and focused on its role in diseases.

© 2021 S. Karger AG, Basel

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First-Page Preview

Abstract of Review

Received: February 10, 2021
Accepted: April 01, 2021
Published online: May 26, 2021

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 2

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE

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