This work was supported by Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA. The funding source was involved in study design and in the writing of the report. SS Moser, L Apter, G Chodick, V Shalev and N Siegelmann-Danieli have no conflict of interest. A Arunachalam and T Burke are employees of Merck & Co., Inc., and own stocks in the company. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.