Testosterone Disorders and Male Hypogonadism in Kidney Disease

The vulnerable man: impact of testosterone deficiency on the uraemic phenotype.

Nephrol Dial Transplant. 27: 4030-4041Khurana KK Navaneethan SD Arrigain S

Serum testosterone level and mortality in men with CKD stages 3-4.

Am J Kidney Dis. 64: 367-374Carrero JJ Qureshi AR Parini P Lindholm B Bárány P Heimbürger O et al.

Low serum testosterone increases mortality risk among male dialysis patients.

J Am Soc Nephrol. 20: 613-620Nieschlag E Behre HM Nieschlag S

Testosterone action, deficiency, substitution.

Cambridge, United Kingdom: Cambridge University Press, Cambridge, UK. : 15-23Bhasin S Brito JP Cunningham GR Hayes FJ Hodis HN Matsumoto AM et al.

Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline.

J Clin Endocrinol Metab. 103: 1715-1744Harman SM Metter EJ Tobin JD Pearson J Blackman MR

Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging.

J Clin Endocrinol Metab. 86: 724-731Roy TA Blackman MR Harman SM Tobin JD Schrager M Metter EJ et al.

Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men.

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Serum sex steroid hormones and frailty in older American men of the Third National Health and Nutrition Examination Survey (NHANES III).

Aging Male. 15: 208-215Haring R Xanthakis V Coviello A Sullivan L Bhasin S Wallaschofski H et al.

Clinical correlates of sex steroids and gonadotropins in men over the late adulthood: the Framingham Heart Study.

Int J Androl. 35: 775-782Gandolfo MT Verzola D Salvatore F Gianiorio F Procopio V Romagnoli A, et al.

Gender and progression of chronic kidney disease: does apoptosis make the difference?.

Minerva Urol Nefrol. 56: 1-14Neugarten J Acharya A Silbiger SR

Effect of gender on the progression of nondiabetic renal disease: a meta-analysis.

J Am Soc Nephrol. 11: 319-329Carrero JJ Hecking M Chesnaye N Jager KJ

Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease.

Nat Rev Nephrol. 14: 151-164Seppi T Prajczer S Dörler MM Eiter O Hekl D Nevinny-Stickel M et al.

Sex differences in renal proximal tubular cell homeostasis.

J Am Soc Nephrol. 27: 3051-3062Blush J Lei L Ju W Silbiger S Pullman J Neugarten J

Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice.

Kidney Int. 66: 2148-2159

Sex and gender differences in cardiovascular, renal and metabolic diseases.

Am J Physiol Regul Integr Comp Physiol. 309: R1057-R1059Doublier S Lupia E Catanuto P Sharon JE

Estrogens and progression of diabetic kidney damage.

Curr Diabetes Rev. 7: 28-34

Gender differences in renal nuclear receptors and aryl hydrocarbon receptor in 5/6 nephrectomized rats.

Kidney Int. 70: 1920-1929Verzola D Gandolfo MT Salvatore F Villaggio B Gianiorio F Traverso P et al.

Testosterone promotes apoptotic proximal tubule damage in human renal tubular cells..

Kidney Int. 65: 1252-1261Verzola D Villaggio B Procopio V Gandolfo MT Gianiorio F Famà A et al.

Androgen-mediated apoptosis of kidney tubule cells: role of c-Jun amino terminal kinase.

Biochem Biophys Res Commun. 387: 531-536Kharaba ZJ Buabeid MA Alfoteih YA

Effectiveness of testosterone therapy in hypogonadal patients and its controversial adverse impact on the cardiovascular system..

Crit Rev Toxicol. 50: 491-512Shores MD Arnold AM Biggs ML Longstreth WT Smith NL Kizer JR et al.

Testosterone and dihydrotestosterone and incident ischaemic stroke in men in the Cardiovascular Health Study.

Clin Endocrinol. 81: 746-753Ruth KS Day FR Tyrrell J Thompson DJ Wood AR Mahajan A et al.

Using human genetics to understand the disease impacts of testosterone in men and women.

Nat Med. 26: 252-258

The hypothalamic-pituitary axis in men and women with chronic kidney disease.

Adv Chronic Kidney Dis. 4: 337-341Dunkel L Raivio T Laine J Holmberg C

Circulating luteinizing hormone receptor inhibitor(s) in boys with chronic renal failure.

Kidney Int. 51: 777-784Gungor O Kircelli F Carrero JJ Asci G Toz H Tataret E et al.

Endogenous testosterone and mortality in male hemodialysis patients: is it the result of aging?.

Clin J Am Soc Nephrol. 5: 2018-2023Kyriazis J Tzanakis I Stylianou K Katsipi I Moisiadis D Papadaki A et al.

Low serum testosterone, arterial stiffness and mortality in male haemodialysis patients.

Nephrol Dial Transplant. 26: 2971-2977Bello AK Stenvinkel P Lin M Hemmelgarn B Thadhani R Klarenbach S et al.

Serum testosterone levels and clinical outcomes in male hemodialysis patients.

Am J Kidney Dis. 63: 268-275Yi S Selvin E Rohrmann S Basaria S Menke A Rifai N et al.

Endogenous sex steroid hormones and measures of chronic kidney disease in a nationally representative sample of men.

Clin Endocrinol. 71: 246-252

The decline of androgen levels in elderly men and its clinical and therapeutic implications.

Endocr Rev. 26: 833-876

Male sexual dysfunction and chronic kidney disease.

Front Med. 4: 32.Yilmaz MI Sonmez A Qureshi AR Saglam M Stenvinkel P Yaman H et al.

Endogenous testosterone, endothelial dysfunction, and cardiovascular events in men with nondialysis chronic kidney disease.

Clin J Am Soc Nephrol. 6: 1617-1625

Relationship between total testosterone, cognitive function, depressive behavior, and sleep quality in chronic kidney disease patients not on dialysis.

Clin Exp Nephrol. 17: 59-65Haring R Nauck M Völzke H Endlich K Lendeckel U Friedrich N et al.

Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy.

Am J Nephrol. 33: 209-217Shoskes DA Kerr H Askar M Goldfarb DA Schold J

Low testosterone at time of transplant is independently associated with poor patient and graft survival in male renal transplant recipients.

J Urol. 192: 1168-1171Lofaro D Perri A Aversa A Aquino B Bonofiglio M La Russa A et al.

Testosterone in renal transplant patients: effect on body composition and clinical parameters.

J Nephrol. 31: 775-783

Pubertal development in children with chronic kidney disease..

Pediatr Nephrol. 32: 949-964Rosas SE Joffe M Franklin E Strom BL Kotzker W Brensinger C et al.

Association of decreased quality of life and erectile dysfunction in hemodialysis patients.

Kidney Int. 64: 232-238Türk S Guney I Altintepe L Tonbul Z Yildiz A Yeksan M

Quality of life in male hemodialysis patients. Role of erectile dysfunction.

Nephron Clin Pract. 96: c21-c27Carrero JJ Bárány P Yilmaz MI Qureshi AR Sonmez A Heimbürger O et al.

Testosterone deficiency is a cause of anaemia and reduced responsiveness to erythropoiesis-stimulating agents in men with chronic kidney disease.

Nephrol Dial Transplant. 27: 709-715Jørgensen HS Winther S Bøttcher M Hauge EM Rejnmark L Svensson M et al.

Bioavailable testosterone is positively associated with bone mineral density in male kidney transplantation candidates.

Kidney Int Rep. 3: 661-670Rettew JA Huet-Hudson YM Marriott I

Testosterone reduces macrophage expression in the mouse of Toll-like receptor 4, a trigger for inflammation and innate immunity.

Biol Reprod. 78: 432-437Nakashima A Ohkido I Yokoyama K Mafune A Urashima M Yokoo T

Testosterone and all-cause mortality and infection-related hospitalization in male hemodialysis patients: a prospective cohort study.

Kidney Int Rep. 2: 1160-1168

Sex differences in severity and mortality from COVID-19: are males more vulnerable?.

Biol Sex Differ. : 53-58Bonanni A Mannucci I Verzola D Sofia A Saffioti S Gianetta E et al.

Protein-energy wasting and mortality in chronic kidney disease.

Int J Environ Res Public Health. 8: 1631-1654Windahl K Irving GF Almquist T Lideen MK van de Luijtgaarden M Chesnaye N, et al.

Prevalence and risk of protein-energy wasting assessed by subjective global assessment in older adults with advanced chronic kidney disease: results from the EQUAL study.

J Ren Nutr. 28: 165-174Kalantar-Zadeh K Moore LW

Improving muscle strength and preventing sarcopenia and cachexia in chronic kidney disease and transplanted patients by physical activity and exercise.

J Ren Nutr. 29: 465-466Garibotto G Picciotto D Saio M Esposito P Verzola D

Muscle protein turnover and low-protein diets in patients with chronic kidney disease.

Nephrol Dial Transplant. 35: 741-751Zhang L Chen Q Chen Z Wang Y Gamboa JL Ikizler TA et al.

Mechanisms regulating muscle protein synthesis in chronic kidney disease.

J Am Soc Nephrol. 31: 2573-2587Church DD Pasiakos SM Wolfe RR Ferrando AA

Acute testosterone administration does not affect muscle anabolism.

Nutr Metab. 16: 1-7Ferrando AA Tipton KD Phillips SM Cortiella PJ Wolfe RJ

Testosterone injection stimulates net protein synthesis but not tissue amino acid transport.

Am J Physiol. 275: E864-E871

Pharmacology of anabolic steroids.

Br J Pharmacol. 154: 502-521Yu JG Bonnerud P Eriksson A Stål PS Yelverton Tegner Y Malm C

Effects of long term supplementation of anabolic androgen steroids on human skeletal muscle.

PLoS One. 9 ()Cigarrán S Pousa M Castro MJ González B Martínez A, Barril G, et al.

Endogenous testosterone, muscle strength, and fat-free mass in men with chronic kidney disease.

J Ren Nutr. 23: e89-e95Rymarz A Matyjek A Gomółka M Niemczyk S

Lean tissue index and body cell mass can be predictors of low free testosterone levels in men on hemodialysis.

J Ren Nutr. 29: 529-535Chiang J Kaysen G Segal M Chertow GM Delgado C Johansen KL et al.

Low testosterone is associated with frailty, muscle wasting, and physical dysfunction among men receiving hemodialysis: a longitudinal analysis.

Nephrol Dial Transplant. 34: 802-810Shoji T Emoto M Nishizawa Y Inaba M

Endocrine and metabolic changes affecting cardiovascular disease in dialysis patients.

J Ren Nut. 25: 223-225Morley JE Vellas B van Kan GA Anker SD Bauer JM Bernabei R et al.

Frailty consensus: a call to action.

J Am Med Dir Assoc. 14: 392-397

Systemic inflammation in the genesis of frailty and sarcopenia: an overview of the preventative and therapeutic role of exercise and the potential for drug treatments.

Geriatrics. 2: 6-11Pialoux T Goyard J Lesourd B

Screening tools for frailty in primary health care: a systematic review.

Geriatr Gerontol Int. 12: 189-197Saad F Röhrig G von Haehling S Traish A

Testosterone deficiency and testosterone treatment in older men.

Gerontology. 63: 144-155Stenvinkel P Carrero JJ von Walden F Ikizler TA Nader GA

Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies.

Nephrol Dial Transplant. 31: 1070-1077Dalrymple LS Katz R Rifkin DE Siscovick D Newman AB Fried LF et al.

Kidney function and prevalent and incident frailty.

Clin J Am Soc Nephrol. 8: 2091-2099

Androgen deficiency as a biological determinant of frailty: hope or hype?.

J Am Geriatr Soc. 62: 1174-1178Johansen KL Dalrymple LS Delgado C Chertow GM Segal MR Chiang J et al.

Factors associated with frailty and its trajectory among patients on hemodialysis.

Clin J Am Soc Nephrol. 12: 1100-1108Wu PY Chao CT Chan DD Huang JW Hung KY

Contributors, risk associates, and complications of frailty in patients with chronic kidney disease: a scoping review.

Ther Adv Chronic Dis. 10: 1-23

Modulatory influence of sex hormones on vascular aging.

Am J Physiol Heart Circ Physiol. 316: H522-H526Khaw KT Dowsett M Folkerd E Bingham S Wareham N Luben R et al.

Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study.

Circulation. 116 ()Haring R Volzke H Steveling A Krebs A Felix SB Schöfl C et al.

Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79.

Eur Heart J. 31 ()Chan YX Knuiman MW Hung J Divitini ML Beilby JP Handelsman DJ et al.

Neutral associations of testosterone, dihydrotestosterone and estradiol with fatal and nonfatal cardiovascular events, and mortality in men aged 17–97 years.

Clin Endocrinol. 85: 575-582Shores MM Biggs ML Arnold AM Smith NL Longstreth Jr, WT Kizer JR et al.

Testosterone, dihydrotestosterone, and incident cardiovascular disease and mortality in the cardiovascular health study.

J Clin Endocrinol Metab. 99: 2061-2068Gagliano-Jucá T Basaria S

Testosterone replacement therapy and cardiovascular risk.

Nat Rev Cardiol. 16: 555-574Cigarrán S Coronel F Florit E Calviño J Villa J Gonzalez Tabares L et al.

Testosterone deficiency in dialysis patients: difference between dialysis techniques.

Nefrologia. 37: 526-530van Eps C Hawley C Jeffries J Johnson DW Campbell S Isbel N et al.

Changes in serum prolactin, sex hormones and thyroid function with alternate nightly nocturnal home haemodialysis.

Nephrology. 17: 42-47Bhasin S Storer TW Berman N Yarasheski KE Clevenger B Phillips J et al.

Testosterone replacement increases fat-free mass and muscle size in hypogonadal men.

J Clin Endocrinol Metab. 82: 407-413Wang YJ Zhan JK Huang W Wang Y Liu Y Wang S et al.

Effects of low-dose testosterone undecanoate treatment on bone mineral density and bone turnover markers in elderly male osteoporosis with low serum testosterone.

Int J Endocrinol. 2013570413Bouloux PM Legros JJ Elbers JM Geurts TB Kaspers MJ Meehan AG et al.

Effects of oral testosterone undecanoate therapy on bone mineral density and body composition in 322 aging men with symptomatic testosterone deficiency: a 1-year, randomized, placebo-controlled, dose-ranging study.

Aging Male. 16: 38-47Yeo JK Koo HS Yu J Park MG

Effects of testosterone treatment on quality of life in patients with chronic kidney disease.

Am J Mens Health. 14 ()Wang C Alexander G Berman N Salehian B Davidson T McDonald V et al.

Testosterone replacement therapy improves mood in hypogonadal men-a clinical research center study.

J Clin Endocrinol Metab. 81: 3578-3583Ottenbacher KJ Ottenbacher ME Ottenbacher AJ Acha AA Ostir GV

Androgen treatment and muscle strength in elderly men: a meta-analysis.

J Am Geriatr Soc. 54: 1666-1673Johansen KL Mulligan K Schambelan M

Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial.

JAMA. 281: 1275-1281Johansen KL Painter PL Sakkas GK Gordon P Doyle J Shubert T

Effects of resistance exercise training and nandrolone decanoate on body composition and muscle function among patients who receive hemodialysis: a randomized, controlled trial.

J Am Soc Nephrol. 17: 2307-2314Supasyndh O Satirapoj B Aramwit P Viroonudomphol D Chaiprasert A Thanachatwej V et al.

Effect of oral anabolic steroid on muscle strength and muscle growth in hemodialysis patients.

Clin J Am Soc Nephrol. 8: 271-279Pampa Saico S Teruel Briones JL Fernández Lucas M Delgado Yagüe M García Cano AM Liaño García F

Treatment of the testosterone deficiency in hemodialysis patients. Preliminary results.

Nefrologia. 36: 462-463Inoue Y Nakamura K Kuwahara Y Lu Y Masuda N Horie S et al.

Efficacy of testosterone treatment in hemodialysis patients as assessed by aging males’ symptoms scores: a pilot study.

Am J Mens Health. 12: 1541-1547Aleksova J Rodriguez AJ McLachlan R Kerr P Milat F Peter R et al.

Gonadal hormones in the pathogenesis and treatment of bone health in patients with chronic kidney disease: a systematic review and meta-analysis.

Osteoporos Rep. 16: 674-692Alexander GC Lyer G Lucas E Lin D Singh S

Cardiovascular risks of exogenous testosterone use among men: a systematic review and meta-analysis.

Am J Med. 130: 293-305Basaria MD Coviello AD Travison TG Storer TW Farwell WR Jette AM et al.

Adverse events associated with testosterone administration.

N Engl J Med. 363: 109-122Snyder PJ Bhasin S Cunningham GR Matsumoto AM Stephens-Shields AJ Cauley JA et al.

Lessons from the testosterone trials.

Endocr Rev. 39: 369-386

The practical management of testosterone deficiency in men.

Nat Rev Urol. 12: 641-650Mulhall JP Trost LW Brannigan RE Kurtz EG Redmon JB Chiles KA et al.

Evaluation and management of testosterone deficiency: AUA guideline.

J Urol. 200: 423-432

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