The work of Bossenko et al. emphasizes the foundational role of semantic interoperability in enabling efficient healthcare delivery and secondary data use. Tools developed for transforming health data formats, such as the transition from CDA to FHIR in Estonia, exemplify the potential of reusable, domain-expert-friendly solutions to address interoperability challenges. Similarly, Bregonzio et al.'s work on FAIRification and data fusion within distributed analytics platforms highlights the importance of creating scalable, reusable, and interoperable data infrastructures. Together, these contributions underline the significance of harmonized data frameworks in driving global healthcare innovation.

Ahmed et al. systematic review examines ethical concerns surrounding precision medicine, emphasizing the patient perspective. Key themes include privacy, economic impacts, informed consent, and the risk of discrimination. Addressing these ethical issues requires proactive patient education, research, and policy reforms to build trust and mitigate risks. These findings complement the recommendations by Kurihara et al., who advocates for a data-driven, participant-centered approach in research ethics, reinforcing the value of dynamic consent, and open science practices in fostering inclusivity and transparency.

Khalil et al.'s exploration of cloud-based regulatory platforms underscores their potential to revolutionize drug development by expediting the review process and enhancing global accessibility. However, realizing this potential requires concerted policy efforts and technological readiness. Sturmberg et al.'s critique of reductionist research methodologies highlights the need for ecosystemic approaches to clinical decision-making, emphasizing the integration of complex, multi-level health determinants.

Figueiredo et al.'s work on Living Labs showcases the value of end-user engagement in designing dementia care solutions. By addressing challenges such as sustainability and scalability, her proposed guidelines aim to maximize the impact of these collaborative innovation methods. Carriazo et al.'s analysis of the Andalusian digital health strategies further illustrates the power of Quadruple Helix collaboration in driving health improvements through ecosystemic approaches.

Laleci Erturkmen et al. and Katehakis et al. focus on the European Health Data Space (EHDS) initiative and the smartHEALTH European Digital Innovation Hub, respectively. Their work underscores the importance of harmonized data standards and interdisciplinary collaboration in advancing precision medicine and AI-driven healthcare services. These initiatives highlight the potential of unified data ecosystems to enhance global clinical research and improve patient outcomes.

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Shift-HUB has received generous funding from the European Union's Horizon Europe research and innovation programme under grant agreement no. 101095720 (1).

Edited and reviewed by: Beatriz S. Lima, Research Institute for Medicines (iMed.ULisboa), Portugal

Copyright © 2025 Koumpis, Bamidis, Costa and Konstantinidis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Adamantios Koumpis, YWRhbWFudGlvcy5rb3VtcGlzQGdtYWlsLmNvbQ==