Rehm J, Samokhvalov AV, Shield KD. Global burden of alcoholic liver diseases. J Hepatol. 2013;59:160–8.

Article  PubMed  Google Scholar 

Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, et al. Alcoholic liver disease. Nat Rev Dis Prim. 2018;4:16.

Article  PubMed  Google Scholar 

Mackowiak B, Fu Y, Maccioni L, Gao B. Alcohol-associated liver disease. J Clin Invest [Internet]. 2024 Feb 1 [cited 2024 Nov 5];134. Available from: https://www.jci.org/articles/view/176345.

Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011;141:1572–85.

Article  CAS  PubMed  Google Scholar 

Pissios P. Nicotinamide N-methyltransferase: more than a vitamin B3 clearance enzyme. Trends Endocrinol Metab. 2017;28:340–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberti A, Fernández AF, Fraga MF. Nicotinamide N-methyltransferase: at the crossroads between cellular metabolism and epigenetic regulation. Mol Metab. 2021;45:101165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Longato L, Ripp K, Setshedi M, Dostalek M, Akhlaghi F, Branda M, et al. Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease. Oxid Med Cell Longev. 2012;2012:e479348.

Article  Google Scholar 

Kaplowitz N, Than TA, Shinohara M, Ji C. Endoplasmic reticulum stress and liver injury. Semin Liver Dis. 2007;27:367–77.

Article  CAS  PubMed  Google Scholar 

Ji C, Kaplowitz N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology. 2003;124:1488–99.

Article  CAS  PubMed  Google Scholar 

Kono H, Rusyn I, Yin M, Gäbele E, Yamashina S, Dikalova A, et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest. 2000;106:867–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508:258–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Komatsu M, Kanda T, Urai H, Kurokochi A, Kitahama R, Shigaki S, et al. NNMT activation can contribute to the development of fatty liver disease by modulating the NAD + metabolism. Sci Rep. 2018;8:8637.

Article  PubMed  PubMed Central  Google Scholar 

Song Q, Chen Y, Wang J, Hao L, Huang C, Griffiths A, et al. ER stress-induced upregulation of NNMT contributes to alcohol-related fatty liver development. J Hepatol. 2020;73:783–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ding Q, Ma Y, Lai S, Dou X, Li S. NNMT aggravates hepatic steatosis, but alleviates liver injury in alcoholic liver disease. J Hepatol. 2021;74:1248–50.

Article  CAS  PubMed  Google Scholar 

Sidor K, Jeznach A, Hoser G, Skirecki T. 1-Methylnicotinamide (1-MNA) inhibits the activation of the NLRP3 inflammasome in human macrophages. Int Immunopharmacol. 2023;121:110445.

Article  CAS  PubMed  Google Scholar 

Biedroń R, Ciszek M, Tokarczyk M, Bobek M, Kurnyta M, Słominska EM, et al. 1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages. Arch Immunol Ther Exp. 2008;56:127–34.

Article  Google Scholar 

Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, et al. How to improve R&D productivity: the pharmaceutical industry’s grand challenge. Nat Rev Drug Discov. 2010;9:203–14.

Article  CAS  PubMed  Google Scholar 

McGonigle P, Ruggeri B. Animal models of human disease: challenges in enabling translation. Biochem Pharmacol. 2014;87:162–71.

Article  CAS  PubMed  Google Scholar 

Plenge RM, Scolnick EM, Altshuler D. Validating therapeutic targets through human genetics. Nat Rev Drug Discov. 2013;12:581–94.

Article  CAS  PubMed  Google Scholar 

Koscielny G, An P, Carvalho-Silva D, Cham JA, Fumis L, Gasparyan R, et al. Open Targets: a platform for therapeutic target identification and validation. Nucleic Acids Res. 2017;45:D985–94.

Article  CAS  PubMed  Google Scholar 

Tian Z, Chen F, Wang J, Wu B, Shao J, Liu Z, et al. CAS Array: design and assessment of a genotyping array for Chinese biobanking. Precis Clin Med. 2023;6:pbad002.

Article  PubMed  PubMed Central  Google Scholar 

Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL, et al. Large-scale integration of the plasma proteome with genetics and disease. Nat Genet. 2021;53:1712–21.

Article  CAS  PubMed  Google Scholar 

Zhang J, Dutta D, Köttgen A, Tin A, Schlosser P, Grams ME, et al. Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies. Nat Genet. 2022;54:593–602.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36:1–48.

Article  Google Scholar 

Schwenzer NF, Springer F, Schraml C, Stefan N, Machann J, Schick F. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol. 2009;51:433–45.

Article  PubMed  Google Scholar 

Sherman KE. Alanine aminotransferase in clinical practice: a review. Arch Intern Med. 1991;151:260–5.

Article  CAS  PubMed  Google Scholar 

McGill MR. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J. 2016;15:817–28.

PubMed  PubMed Central  Google Scholar 

Holmes RS, Duley JA, Algar EM, Mather PB, Rout UK. Biochemical and genetic studies on enzymes of alcohol metabolism: the mouse as a model organism for human studies. Alcohol Alcohol. 1986;21:41–56.

CAS  PubMed  Google Scholar 

Liu SX, Du YC, Zeng T. A mini-review of the rodent models for alcoholic liver disease: shortcomings, application, and future prospects. Toxicol Res. 2021;10:523–30.

Article  Google Scholar 

Mestas J, Hughes CCW. Of mice and not men: differences between mouse and human immunology. J Immunol. 2004;172:2731–8.

Article  CAS  PubMed  Google Scholar 

Hines IN, Wheeler MD. Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis. Am J Physiol-Gastrointest Liver Physiol. 2004;287:G310–4.

Article  CAS  PubMed  Google Scholar 

Altamirano J, Bataller R. Alcoholic liver disease: pathogenesis and new targets for therapy. Nat Rev Gastroenterol Hepatol. 2011;8:491–501.

Article  CAS  PubMed  Google Scholar 

Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, et al. Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database. Toxicol Appl Pharmacol. 2017;334:100–9.

Article  CAS  PubMed  Google Scholar