Ahamad A, Kumar J (2023) Pyrethroid pesticides: an overview on classification, toxicological assessment and monitoring. J Hazard Mater Adv 10:100284

Article  Google Scholar 

Ahmed T, Zulfiqar A, Arguelles S, Rasekhian M, Nabavi SF, Silva AS, Nabavi SM (2020) Map kinase signaling as therapeutic target for neurodegeneration. Pharmacol Res 160:105090

Article  PubMed  Google Scholar 

Ali S, Ullah MI, Sajjad A, Shakeel Q, Hussain A (2021) Environmental and health effects of pesticide residues. Sustainable Agric Reviews 48(Pesticide Occurrence, Analysis and Remediation 2 Analysis):311–336

Article  Google Scholar 

Alotaibi BS, Abdel-Rahman Mohamed A, Abd-Elhakim YM, Noreldin AE, Elhamouly M, Khamis T, Di Cerbo A (2024) Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and in-silico approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles. Front Pharmacol 15:1388784

Article  PubMed  PubMed Central  Google Scholar 

Althagafy HS, Hassanein EH (2024) Fluoxetine attenuates chlorpyrifos-induced neuronal injury through the PPARγ, SIRT1, NF-κB, and JAK1/STAT3 signals. Int Immunopharmacol 136:112335

Article  PubMed  Google Scholar 

Altinoz MA, Elmaci I, Hacimuftuoglu A, Ozpinar A, Hacker E, Ozpinar A (2021) PPARδ and its ligand erucic acid may act anti-tumoral, neuroprotective, and myelin protective in neuroblastoma, glioblastoma, and Parkinson’s disease. Mol Aspects Med 78:100871

Article  PubMed  Google Scholar 

Anadón A, Martínez-Larrañaga MR, Martínez MA (2009) Use and abuse of pyrethrins and synthetic pyrethroids in veterinary medicine. Vet J 182(1):7–20

Article  PubMed  Google Scholar 

Andersen HR, David A, Freire C, Fernández MF, d’Cruz SC, Reina-Pérez I, Blaha L (2022) Pyrethroids and developmental neurotoxicity-A critical review of epidemiological studies and supporting mechanistic evidence. Environ Res 214:113935

Article  PubMed  Google Scholar 

Ansari I, El-Kady MM, Arora C, Sundararajan M, Maiti D, Khan A (2021) A review on the fatal impact of pesticide toxicity on environment and human health. Global Clim Change, 361–391

Arsuffi-Marcon R, Souza LG, Santos-Miranda A, Joviano-Santos JV (2024) Neurotoxicity of Pyrethroids in exacerbating neurodegenerative diseases: From animals’ models to humans’ studies. Chemico-Biol Interact, 110911

Atere AD, Moronkeji A, Moronkeji AI, Osadolor HB (2021) Serum levels of inflammatory biomarkers, glycaemic control indices and leptin receptors expression in adult male wistar rats exposed to pyrethroids. J Cell Biotechnol 7(1):41–55

Article  Google Scholar 

Barrios-Arpi L, Arias Y, Lopez-Torres B, Ramos-Gonzalez M, Ticli G, Prosperi E, Rodríguez JL (2022) In vitro neurotoxicity of flumethrin pyrethroid on SH-SY5Y neuroblastoma cells: apoptosis associated with oxidative stress. Toxics 10(3):131

Article  PubMed  PubMed Central  Google Scholar 

Bennett DL, Clark AJ, Huang J, Waxman SG, Dib-Hajj SD (2019) The role of voltage-gated sodium channels in pain signaling. Physiol Rev 99(2):1079–1151

Article  PubMed  Google Scholar 

Bhardwaj K, Sharma R, Abraham J, Sharma P (2020) Pyrethroids: a natural product for crop protection. Nat Bioactive Prod Sustainable Agric, 113–130

Bhardwaj S, Grewal AK, Singh S, Dhankar V, Jindal A (2024) An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer’s disease: targeting molecular approach Nrf2, NF-κB, and CREB. Inflammopharmacology, 1–18

Bordoni L, Nasuti C, Mirto M, Caradonna F, Gabbianelli R (2015) Intergenerational effect of early life exposure to permethrin: changes in global DNA methylation and in Nurr1 gene expression. Toxics 3(4):451–461

Article  PubMed  PubMed Central  Google Scholar 

Bordoni L, Nasuti C, Fedeli D, Galeazzi R, Laudadio E, Massaccesi L, Gabbianelli R (2019) Early impairment of epigenetic pattern in neurodegeneration: additional mechanisms behind pyrethroid toxicity. Exp Gerontol 124:110629

Article  PubMed  Google Scholar 

Bottino-Rojas V, Talyuli OA, Carrara L, Martins AJ, James AA, Oliveira PL, Paiva-Silva GO (2018) The redox-sensing gene Nrf2 affects intestinal homeostasis, insecticide resistance, and Zika virus susceptibility in the mosquito aedes aegypti. J Biol Chem 293(23):9053–9063

Article  PubMed  PubMed Central  Google Scholar 

Boutin C (2020) Herbicides: Non-target species effects. Managing Global resources and Universal processes. CRC, pp 33–48

Bradberry SM, Cage SA, Proudfoot AT, Vale JA (2005) Poisoning due to pyrethroids. Toxicol Rev 24:93–106

Article  PubMed  Google Scholar 

Breckenridge CB, Holden L, Sturgess N, Weiner M, Sheets L, Sargent D, Ray D (2009) Evidence for a separate mechanism of toxicity for the type I and the type II pyrethroid insecticides. Neurotoxicology 30:S17–S31

Article  PubMed  Google Scholar 

Brini M, Calì T, Ottolini D, Carafoli E (2014) Neuronal calcium signaling: function and dysfunction. Cell Mol Life Sci 71:2787–2814

Article  PubMed  PubMed Central  Google Scholar 

Bülow P, Segal M, Bassell GJ (2022) Mechanisms driving the emergence of neuronal hyperexcitability in fragile X syndrome. Int J Mol Sci 23(11):6315

Article  PubMed  PubMed Central  Google Scholar 

Carloni M, Nasuti C, Fedeli D, Montani M, Amici A, Vadhana MD, Gabbianelli R (2012) The impact of early life permethrin exposure on development of neurodegeneration in adulthood. Exp Gerontol 47(1):60–66

Article  PubMed  Google Scholar 

Carloni M, Nasuti C, Fedeli D, Montani M, Vadhana MD, Amici A, Gabbianelli R (2013) Early life permethrin exposure induces long-term brain changes in Nurr1, NF-kB and Nrf-2. Brain Res 1515:19–28

Article  PubMed  Google Scholar 

Clark JM, Symington SB (2007) Pyrethroid action on calcium channels: neurotoxicological implications. Invertebr Neurosci 7:3–16

Article  Google Scholar 

Cooke MS, Evans MD, Dizdaroglu M, Lunec J (2003) Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17(10):1195–1214

Article  PubMed  Google Scholar 

Curtis MA, Dhamsania RK, Branco RC, Guo JD, Creeden J, Neifer KL, Burkett JP (2023) Developmental pyrethroid exposure causes a neurodevelopmental disorder phenotype in mice. PNAS nexus 2(4):pgad085

Article  PubMed  PubMed Central  Google Scholar 

Davies TGE, Field LM, Usherwood PNR, Williamson MS (2007) DDT, pyrethrins, pyrethroids and insect sodium channels. IUBMB Life 59(3):151–162

Article  PubMed  Google Scholar 

Davies TGE, Field LM, Williamson MS (2012) The re-emergence of the bed bug as a nuisance pest: implications of resistance to the pyrethroid insecticides. Med Vet Entomol 26(3):241–254

Article  PubMed  Google Scholar 

Denac H, Mevissen M, Scholtysik G (2000) Structure, function and pharmacology of voltage-gated sodium channels. Naunyn Schmiedebergs Arch Pharmacol 362:453–479

Article  PubMed  Google Scholar 

Deuis JR, Mueller A, Israel MR, Vetter I (2017) The pharmacology of voltage-gated sodium channel activators. Neuropharmacology 127:87–108

Article  PubMed  Google Scholar 

Duarte V, Amorim FA, Palmeira JM, C., Rolo P, A (2015) Regulation of mitochondrial function and its impact in metabolic stress. Curr Med Chem 22(20):2468–2479

Article  PubMed  Google Scholar 

Farag MR, Alagawany M, Bilal RM, Gewida AG, Dhama K, Abdel-Latif HM, Naiel MA (2021) An overview on the potential hazards of pyrethroid insecticides in fish, with special emphasis on cypermethrin toxicity. Animals 11(7):1880

Article  PubMed  PubMed Central  Google Scholar 

Farkhondeh T, Mehrpour O, Buhrmann C, Pourbagher-Shahri AM, Shakibaei M, Samarghandian S (2020a) Organophosphorus compounds and MAPK signaling pathways. Int J Mol Sci 21(12):4258

Article  PubMed  PubMed Central  Google Scholar 

Farkhondeh T, Mehrpour O, Forouzanfar F, Roshanravan B, Samarghandian S (2020b) Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review. Environ Sci Pollut Res 27:24799–24814

Article  Google Scholar 

Figueiredo DM, Krop EJ, Duyzer J, Gerritsen-Ebben RM, Gooijer YM, Holterman HJ, Vermeulen RC (2021) Pesticide exposure of residents living close to agricultural fields in the Netherlands: protocol for an observational study. JMIR Res Protocols, 10(4), e27883

Fluegge KR, Nishioka M, Wilkins III, J. R (2016) Effects of simultaneous prenatal exposures to organophosphate and synthetic pyrethroid insecticides on infant neurodevelopment at three months of age. J Environ Toxiology Public Health 1:60

Google Scholar 

Gargouri B, Yousif NM, Attaai A, Bouchard M, Chtourou Y, Fiebich BL, Fetoui H (2018) Pyrethroid bifenthrin induces oxidative stress, neuroinflammation, and neuronal damage, associated with cognitive and memory impairment in murine hippocampus. Neurochem Int 120:121–133

Article  PubMed  Google Scholar 

Gibney ER, Nolan CM (2010) Epigenetics and gene expression. Heredity 105(1):4–13

Article  PubMed  Google Scholar