Front. Neurosci.

Sec. Gut-Brain Axis

Volume 18 - 2024 | doi: 10.3389/fnins.2024.1501134

This article is part of the Research Topic Reviews in Gut-Brain Axis: Stress, dysregulation in gut-brain axis function and stress related disorders View all 7 articles

Provisionally accepted

Min Jiang 1* Li Kang 2 Ya-Li Wang 3 Bin Zhou 3 Hong-Yi Li 3 Qiang Yan 4 Zhi-Gang Liu 1 1 Department of Clinical Laboratory, Neijiang Central District People’s Hospital, Nejiang, China 2 Department of Anesthesiology, The First People's Hospital of Neijiang, Neijiang, China 3 Department of Neurology, Neijiang Central District People’s Hospital, Neijiang, China 4 Department of Clinical Laboratory, Neijiang Central District People’s Hospital, Neijiang, China

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Anxiety disorders, prevalent mental health conditions, receive significant attention globally due to their intricate etiology and the suboptimal effectiveness of existing therapies. Research is increasingly recognizing that the genesis of anxiety involves not only neurochemical brain alterations but also changes in gut microbiota. The microbiota-gut-brain axis (MGBA), serving as a bidirectional communication pathway between the gut microbiota and the central nervous system (CNS), is at the forefront of novel approaches to deciphering the complex pathophysiology of anxiety disorders. This review scrutinizes the role and recent advancements in the MGBA concerning anxiety disorders through a review of the literature, emphasizing mechanisms via neural signals, endocrine pathways, and immune responses. The evidence robustly supports the critical influence of MGBA in both the development and progression of these disorders. Furthermore, this discussion explores potential therapeutic avenues stemming from these insights, alongside the challenges and issues present in this realm. Collectively, our findings aim to enhance understanding of the pathological mechanisms and foster improved preventative and therapeutic strategies for anxiety disorders.

Keywords: Anxiety Disorders, Gut Microbiota, MGBA, Neural signal, Endocrine pathways, immune pathways

Received: 24 Sep 2024; Accepted: 26 Nov 2024.

Copyright: © 2024 Jiang, Kang, Wang, Zhou, Li, Yan and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Min Jiang, Department of Clinical Laboratory, Neijiang Central District People’s Hospital, Nejiang, China

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