Front. Cell. Infect. Microbiol.

Sec. Clinical Microbiology

Volume 14 - 2024 | doi: 10.3389/fcimb.2024.1484371

Provisionally accepted

Jinglin Zhao 1* Li Jiang 1 Weizhi He 1* Dingrui Han 1* Xuan Yang 1* Liuli Wu 2* Haiyan Zhong 1* 1 Kunming Children's Hospital, Kunming, Yunnan Province, China 2 School of Medicine, Kunming University of Science and Technology, Kunming, China

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Sepsis is a systemic inflammatory response syndrome of multiorgan failure caused by dysregulation of the host response to infection and is a major cause of death in critically ill patients. In recent years, with the continuous development of sequencing technology, the intestinal microecology of this disease has been increasingly studied.The gut microbiota plays a host-protective role mainly through the maintenance of normal immune function and the intestinal barrier. Recent evidence suggests that intestinal flora dysbiosis plays a crucial role in sepsis. Clostridium butyricum (C. butyricum), which has been used as a probiotic in poultry feed since its discovery, has been found to play a potential protective role in intestinal infections, inflammatory bowel disease (IBD), colorectal cancer, and other diseases in recent studies. In this review, we continue to focus on the important role and mechanism of C. butyricum as a probiotic in human diseases, especially intestinal diseases. Additionally, we evaluate the research progress of C. butyricum in treatment of sepsis to identify more therapeutic targets for the clinical treatment of sepsis.

Keywords: Sepsis, Clostridium butyricum, Probiotics, Treatment, Gut Microbiota

Received: 21 Aug 2024; Accepted: 19 Nov 2024.

Copyright: © 2024 Zhao, Jiang, He, Han, Yang, Wu and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Jinglin Zhao, Kunming Children's Hospital, Kunming, 650221, Yunnan Province, China
Weizhi He, Kunming Children's Hospital, Kunming, 650221, Yunnan Province, China
Dingrui Han, Kunming Children's Hospital, Kunming, 650221, Yunnan Province, China
Xuan Yang, Kunming Children's Hospital, Kunming, 650221, Yunnan Province, China
Liuli Wu, School of Medicine, Kunming University of Science and Technology, Kunming, China
Haiyan Zhong, Kunming Children's Hospital, Kunming, 650221, Yunnan Province, China

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