Wanis HA, Møller H, Ashkan K, Davies EA. The incidence of major subtypes of primary brain tumors in adults in England 1995–2017. Neuro Oncol. 2021;23(8):1371–82. https://doi.org/10.1093/neuonc/noab076.

Article  PubMed  PubMed Central  Google Scholar 

Riano I, Bravo P, Bravo LE, Garcia LS, Collazos P, Carrascal E. Incidence, mortality, and survival trends of primary CNS tumors in Cali, Colombia, from 1962 to 2019. JCO Glob Oncol. 2020;6:1712–20. https://doi.org/10.1200/GO.20.00368.

Article  PubMed  Google Scholar 

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, Bray F. Cancer statistics for the year 2020: an overview. Int J Cancer. 2021. https://doi.org/10.1002/ijc.33588.

Article  PubMed  Google Scholar 

Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P. Molecular pathology of tumors of the central nervous system. Ann Oncol. 2019;30(8):1265–78. https://doi.org/10.1093/annonc/mdz164.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong J, Xing X, Gao Y, Pei L, Lu C, Sun H, Lai Y, Du K, Xiao F, Yang Y, Wang X, Shi Y, Bai F, Zhang N. Distinct roles of TREM2 in central nervous system cancers and peripheral cancers. Cancer Cell. 2024;42(6):968-984.e9. https://doi.org/10.1016/j.ccell.2024.05.001.

Article  CAS  PubMed  Google Scholar 

Carballo GB, Honorato JR, de Lopes GPF, Spohr TC. A highlight on Sonic Hedgehog pathway. Cell Commun Signal. 2018;16(1):11. https://doi.org/10.1186/s12964-018-0220-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Powter B, Jeffreys SA, Sareen H, Cooper A, Brungs D, Po J, Roberts T, Koh ES, Scott KF, Sajinovic M, Vessey JY, de Souza P, Becker TM. Human TERT promoter mutations as a prognostic biomarker in glioma. J Cancer Res Clin Oncol. 2021;147(4):1007–17. https://doi.org/10.1007/s00432-021-03536-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Cui B, Li X, Zhao X, Huang T, Ding X. The emerging roles of Hedgehog signaling in tumor immune microenvironment. Front Oncol. 2023;13:1171418. https://doi.org/10.3389/fonc.2023.1171418.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jha NK, Chen WC, Kumar S, Dubey R, Tsai LW, Kar R, Jha SK, Gupta PK, Sharma A, Gundamaraju R, Pant K, Mani S, Singh SK, Maccioni RB, Datta T, Singh SK, Gupta G, Prasher P, Dua K, Dey A, Sharma C, Mughal YH, Ruokolainen J, Kesari KK, Ojha S. Molecular mechanisms of developmental pathways in neurological disorders: a pharmacological and therapeutic review. Open Biol. 2022;12(3): 210289. https://doi.org/10.1098/rsob.210289.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu K, McGlynn S, Matise MP. Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Development. 2013;140(7):1594–604. https://doi.org/10.1242/dev.090845.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Placzek M, Briscoe J. Sonic hedgehog in vertebrate neural tube development. Int J Dev Biol. 2018;62(1):225–34. https://doi.org/10.1387/ijdb.170293jb.

Article  CAS  PubMed  Google Scholar 

Cheng C, Cong Q, Liu Y, Hu Y, Liang G, Dioneda KMM, Yang Y. Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression. Sci Adv. 2023;9(24):eadf6927. https://doi.org/10.1126/sciadv.adf6927.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhandari J, Thada PK. Neural tube disorders. In: StatPearls. Treasure Island: StatPearls Publishing. 2024.

Komada M. Sonic hedgehog signaling coordinates the proliferation and differentiation of neural stem/progenitor cells by regulating cell cycle kinetics during development of the neocortex. Congenit Anom (Kyoto). 2012;52(2):72–7. https://doi.org/10.1111/j.1741-4520.2012.00368.x.

Article  PubMed  Google Scholar 

Loo CKC, Pearen MA, Ramm GA. The role of Sonic Hedgehog in human holoprosencephaly and short-rib polydactyly syndromes. Int J Mol Sci. 2021;22(18):9854. https://doi.org/10.3390/ijms22189854.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greene ND, Copp AJ. Neural tube defects. Annu Rev Neurosci. 2014;37:221–42. https://doi.org/10.1146/annurev-neuro-062012-170354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murdoch JN, Copp AJ. The relationship between sonic Hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol. 2010;88(8):633–52. https://doi.org/10.1002/bdra.20686.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Briscoe J, Thérond PP. The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol. 2013;14(7):416–29. https://doi.org/10.1038/nrm3598.

Article  CAS  PubMed  Google Scholar 

Achilleos A, Trainor PA. Neural crest stem cells: discovery, properties and potential for therapy. Cell Res. 2012;22(2):288–304. https://doi.org/10.1038/cr.2012.11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Juliandi B, Abematsu M, Nakashima K. Epigenetic regulation in neural stem cell differentiation. Dev Growth Differ. 2010;52(6):493–504. https://doi.org/10.1111/j.1440-169X.2010.01175.x.

Article  CAS  PubMed  Google Scholar 

Daynac M, Tirou L, Faure H, Mouthon MA, Gauthier LR, Hahn H, Boussin FD, Ruat M. Hedgehog controls quiescence and activation of neural stem cells in the adult ventricular-subventricular zone. Stem Cell Reports. 2016;7(4):735–48. https://doi.org/10.1016/j.stemcr.2016.08.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang W, Shiraishi R, Kawauchi D. Sonic Hedgehog signaling in cerebellar development and cancer. Front Cell Dev Biol. 2022;29(10): 864035. https://doi.org/10.3389/fcell.2022.864035.

Article  Google Scholar 

Yang C, Qi Y, Sun Z. The role of Sonic Hedgehog pathway in the development of the central nervous system and aging-related neurodegenerative diseases. Front Mol Biosci. 2021;8(8): 711710. https://doi.org/10.3389/fmolb.2021.711710.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang C, Li S, Li X, Li H, Li Y, Zhang C, Lin J. Effect of sonic hedgehog on motor neuron positioning in the spinal cord during chicken embryonic development. J Cell Mol Med. 2019;23(5):3549–62. https://doi.org/10.1111/jcmm.14254.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuhn NF, Purdon TJ, van Leeuwen DG, Lopez AV, Curran KJ, Daniyan AF, Brentjens RJ. CD40 ligand-modified chimeric antigen receptor T cells enhance antitumor function by eliciting an endogenous antitumor response. Cancer Cell. 2019;35(3):473-488.e6. https://doi.org/10.1016/j.ccell.2019.02.006.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pietrobono S, Gagliardi S, Stecca B. Non-canonical hedgehog signaling pathway in cancer: activation of gli transcription factors beyond smoothened. Front Genet. 2019;12:10. https://doi.org/10.3389/fgene.2019.00556.

Article  CAS  Google Scholar 

Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R. The output of hedgehog signaling is controlled by the dynamic association between suppressor of fused and the gli proteins. Genes Dev. 2010;24(7):670–82. https://doi.org/10.1101/gad.1902910.

Article  CAS  PubMed  PubMed Central