Brosens JJ, Bennett PR, Abrahams VM, Ramhorst R, Coomarasamy A, Quenby S, Lucas ES, McCoy RC. Maternal selection of human embryos in early gestation: insights from recurrent miscarriage. Semin Cell Dev Biol. 2022;131:14–24. https://doi.org/10.1016/j.semcdb.2022.01.007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cakmak H, Taylor HS. Implantation failure: molecular mechanisms and clinical treatment. Hum Reprod Update. 2011;17(2):242–53. https://doi.org/10.1093/humupd/dmq037.

Article  CAS  PubMed  Google Scholar 

Scott RT Jr, Ferry K, Su J, Tao X, Scott K, Treff NR. Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study. Fertil Steril. 2012;97(4):870–5. https://doi.org/10.1016/j.fertnstert.2012.01.104.

Article  PubMed  Google Scholar 

Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT Jr. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertil Steril. 2021;115(3):627–37. https://doi.org/10.1016/j.fertnstert.2020.07.052.

Article  CAS  PubMed  Google Scholar 

Gruhn JR, Zielinska AP, Shukla V, Blanshard R, Capalbo A, Cimadomo D, Nikiforov D, Chan AC, Newnham LJ, Vogel I, Scarica C, Krapchev M, Taylor D, Kristensen SG, Cheng J, Ernst E, Bjørn AB, Colmorn LB, Blayney M, Elder K, Liss J, Hartshorne G, Grøndahl ML, Rienzi L, Ubaldi F, McCoy R, Lukaszuk K, Andersen CY, Schuh M, Hoffmann ER. Chromosome errors in human eggs shape natural fertility over reproductive life span. Science. 2019;365(6460):1466–9. https://doi.org/10.1126/science.aav7321.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capalbo A, Hoffmann ER, Cimadomo D, Ubaldi FM, Rienzi L. Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imaging. Hum Reprod Update. 2017;23(6):706–22. https://doi.org/10.1093/humupd/dmx026.

Article  CAS  PubMed  Google Scholar 

Orvieto R. The use of preimplantation genetic testing for aneuploidy: a committee opinion. Fertil Steril. 2024;12(3):421–34. https://doi.org/10.1016/j.fertnstert.2024.05.166.

Article  Google Scholar 

Munne S, Kaplan B, Frattarelli JL, Child T, Nakhuda G, Shamma FN, et al. Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial. Fertil Steril. 2019;112:1071-9.e7. https://doi.org/10.1016/j.fertnstert.2019.07.1346.

Article  CAS  PubMed  Google Scholar 

Yan J, Qin Y, Zhao H, Sun Y, Gong F, Li R, et al. Live birth with or without preimplantation genetic testing for aneuploidy. N Engl J Med. 2021;385:2047–58. https://doi.org/10.1056/NEJMoa2103613.

Article  CAS  PubMed  Google Scholar 

El-Toukhy T, Kopeika JY, Beebeejaun Y, El Tokhy O, Pundir J, Khalaf Y. Impact of the outcome of fresh blastocyst transfer on the subsequent frozen-thawed blastocyst transfer cycle. Reprod Biomed Online. 2017;35(5):536–41. https://doi.org/10.1016/j.rbmo.2017.06.024.

Article  CAS  PubMed  Google Scholar 

Pirtea P, de Ziegler D, Tao X, Sun L, Zhan Y, Ayoubi JM, Seli E, Franasiak JM, Scott RT Jr. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertil Steril. 2021;115(1):45–53. https://doi.org/10.1016/j.fertnstert.2020.07.002.

Article  PubMed  Google Scholar 

Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, Cutting R, Ong K, Sallam H, Li TC. Recurrent implantation failure: definition and management. Reprod Biomed Online. 2014;28(1):14–38. https://doi.org/10.1016/j.rbmo.2013.08.011.

Article  CAS  PubMed  Google Scholar 

Boynukalin FK, Gultomruk M, Cavkaytar S, Turgut E, Findikli N, Serdarogullari M, Coban O, Yarkiner Z, Rubio C, Bahceci M. Parameters impacting the live birth rate per transfer after frozen single euploid blastocyst transfer. PLoS ONE. 2020;15(1):e0227619. https://doi.org/10.1371/journal.pone.0227619.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gardner DK, Schoolcraft WB. Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol. 1999;11(3):307–11. https://doi.org/10.1097/00001703-199906000-00013.

Article  CAS  PubMed  Google Scholar 

Zhao H, Tao W, Li M, Liu H, Wu K, Ma S. Comparison of two protocols of blastocyst biopsy submitted to preimplantation genetic testing for aneuploidies: a randomized controlled trial. Arch Gynecol Obstet. 2019;299(5):1487–93. https://doi.org/10.1007/s00404-019-05084-1.

Article  PubMed  Google Scholar 

Garrisi JG, Colls P, Ferry KM, Zheng X, Garrisi MG, Munné S. Effect of infertility, maternal age, and number of previous miscarriages on the outcome of preimplantation genetic diagnosis for idiopathic recurrent pregnancy loss. Fertil Steril. 2009;92(1):288–95. https://doi.org/10.1016/j.fertnstert.2008.05.056.

Article  PubMed  Google Scholar 

Hodes-Wertz B, Grifo J, Ghadir S, Kaplan B, Laskin CA, Glassner M, Munné S. Idiopathic recurrent miscarriage is caused mostly by aneuploid embryos. Fertil Steril. 2012;98(3):675–80. https://doi.org/10.1016/j.fertnstert.2012.05.025.

Article  PubMed  Google Scholar 

Murugappan G, Shahine LK, Perfetto CO, Hickok LR, Lathi RB. Intent to treat analysis of in vitro fertilization and preimplantation genetic screening versus expectant management in patients with recurrent pregnancy loss. Hum Reprod. 2016;31(8):1668–74. https://doi.org/10.1093/humrep/dew135.

Article  PubMed  Google Scholar 

Wang A, Kort J, Westphal L. Miscarriage history association with euploid embryo transfer outcomes. Reprod Biomed Online. 2019;39(4):617–23. https://doi.org/10.1016/j.rbmo.2019.05.011.

Article  CAS  PubMed  Google Scholar 

Flenady V, Koopmans L, Middleton P, Frøen JF, Smith GC, Gibbons K, Coory M, Gordon A, Ellwood D, McIntyre HD, Fretts R, Ezzati M. Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet. 2011;377(9774):1331–40. https://doi.org/10.1016/S0140-6736(10)62233-7.

Article  PubMed  Google Scholar 

Huang L, Sauve R, Birkett N, Fergusson D, van Walraven C. Maternal age and risk of stillbirth: a systematic review. CMAJ. 2008;178(2):165–72. https://doi.org/10.1503/cmaj.070150.

Article  PubMed  PubMed Central  Google Scholar 

Nelson SM, Lawlor DA. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilisation: a prospective study of 144,018 treatment cycles. PLoS Med. 2011;8(1):e1000386. https://doi.org/10.1371/journal.pmed.1000386.

Article  PubMed  PubMed Central  Google Scholar 

Check JH, Nowroozi K, Chase J, Nazari A, Braithwaite C. Comparison of pregnancy rates following in vitro fertilization-embryo transfer between the donors and the recipients in a donor oocyte program. J Assist Reprod Genet. 1992;9(3):248–50. https://doi.org/10.1007/BF01203822.

Article  CAS  PubMed  Google Scholar 

Stafford-Bell MA, Copeland CM. Surrogacy in Australia: implantation rates have implications for embryo quality and uterine receptivity. Reprod Fertil Dev. 2001;13(1):99–104. https://doi.org/10.1071/rd00044.

Article  CAS  PubMed  Google Scholar 

Magnus MC, Wilcox AJ, Morken NH, Weinberg CR, Håberg SE. Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study. BMJ. 2019;364:l869. https://doi.org/10.1136/bmj.l869.

Article  PubMed  PubMed Central  Google Scholar 

Mejia RB, Capper EA, Summers KM, Mancuso AC, Sparks AE, Van Voorhis BJ. Cumulative live birth rate in women aged ≤37 years after in vitro fertilization with or without preimplantation genetic testing for aneuploidy: a Society for Assisted Reproductive Technology Clinic Outcome Reporting System retrospective analysis. F&S Rep. 2022;3(3):184–91. https://doi.org/10.1016/j.xfre.2022.05.004.

Article  Google Scholar 

Kucherov A, Fazzari M, Harry Lieman G, Ball D, Doody K, Jindal S. PGT-A is associated with reduced cumulative live birth rate in first reported IVF stimulation cycles age ≤ 40: an analysis of 133,494 autologous cycles reported to SART CORS. J Assist Reprod Genet. 2023;40(1):137–49. https://doi.org/10.1007/s10815-022-02667-x.

Article  PubMed