Kanova M, Kohout P. Serotonin-its synthesis and roles in the healthy and the critically ill. Int J Mol Sci. 2021;22:4837.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mohammad-Zadeh LF, Moses L, Gwaltney-Brant SM. Serotonin: a review. J Vet Pharm Ther. 2008;31:187–99.

Article  CAS  Google Scholar 

Berger M, Gray JA, Roth BL. The expanded biology of serotonin. Annu Rev Med. 2009;60:355–66.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Canli T, Lesch KP. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat Neurosci. 2007;10:1103–9.

Article  PubMed  CAS  Google Scholar 

Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology. 1999;38:1083–152.

Article  PubMed  CAS  Google Scholar 

Iurescia S, Seripa D, Rinaldi M. Role of the 5-HTTLPR and SNP promoter polymorphisms on serotonin transporter gene expression: a closer look at genetic architecture and in vitro functional studies of common and uncommon allelic variants. Mol Neurobiol. 2016;53:5510–26.

Article  PubMed  CAS  Google Scholar 

Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996;66:2621–4.

Article  PubMed  CAS  Google Scholar 

Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527–31.

Article  PubMed  CAS  Google Scholar 

Heils A, Mössner R, Lesch KP. The human serotonin transporter gene polymorphism–basic research and clinical implications. J Neural Transm. 1997;104:1005–14.

Article  PubMed  CAS  Google Scholar 

Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301:386–9.

Article  PubMed  CAS  Google Scholar 

Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet. 2004;127b:85–9.

Article  PubMed  Google Scholar 

Culverhouse RC, Saccone NL, Horton AC, Ma Y, Anstey KJ, Banaschewski T, et al. Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol Psychiatry. 2018;23:133–42.

Article  PubMed  CAS  Google Scholar 

Border R, Johnson EC, Evans LM, Smolen A, Berley N, Sullivan PF, et al. No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples. Am J Psychiatry. 2019;176:376–87.

Article  PubMed  PubMed Central  Google Scholar 

Ikegame T, Hidaka Y, Nakachi Y, Murata Y, Watanabe R, Sugawara H, et al. Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region. Transl Psychiatry. 2021;11:119.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006;78:815–26.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nakamura M, Ueno S, Sano A, Tanabe H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry. 2000;5:32–8.

Article  PubMed  CAS  Google Scholar 

Ikegame T, Bundo M, Okada N, Murata Y, Koike S, Sugawara H, et al. Promoter activity-based case-control association study on SLC6A4 highlighting hypermethylation and altered amygdala volume in male patients with schizophrenia. Schizophr Bull. 2020;46:1577–86.

Article  PubMed  PubMed Central  Google Scholar 

Marchini J, Howie B. Genotype imputation for genome-wide association studies. Nat Rev Genet. 2010;11:499–511.

Article  PubMed  CAS  Google Scholar 

Li N, Stephens M. Modeling linkage disequilibrium and identifying recombination hotspots using single-nucleotide polymorphism data. Genetics. 2003;165:2213–33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Naito T, Suzuki K, Hirata J, Kamatani Y, Matsuda K, Toda T, et al. A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes. Nat Commun. 2021;12:1639.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Border R, Smolen A, Corley RP, Stallings MC, Brown SA, Conger RD, et al. Imputation of behavioral candidate gene repeat variants in 486,551 publicly-available UK Biobank individuals. Eur J Hum Genet. 2019;27:963–9.

Article  PubMed  PubMed Central  Google Scholar 

Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, et al. Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). Environ Health Prev Med. 2020;25:64.

Article  PubMed  PubMed Central  Google Scholar 

Akiyama M, Ishigaki K, Sakaue S, Momozawa Y, Horikoshi M, Hirata M, et al. Characterizing rare and low-frequency height-associated variants in the Japanese population. Nat Commun. 2019;10:4393.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001;68:978–89.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stephens M, Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet. 2005;76:449–62.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nassar LR, Barber GP, Benet-Pagès A, Casper J, Clawson H, Diekhans M, et al. The UCSC Genome Browser database: 2023 update. Nucleic Acids Res. 2023;51:D1188–d95.

Article  PubMed  CAS  Google Scholar