Exploring genetic signatures of obesity: hub genes and miRNAs unveiled through comprehensive bioinformatic analysis

Milhem F, Komarnytsky S. Progression to obesity: variations in patterns of metabolic fluxes, fat accumulation, and gastrointestinal responses. Metabolites. 2023;13(9):1016.

Юдин A, Кaлтыгин M, Кoнoвaлoв E, Bлacoв A, Aльтoв Д, Бaтoв B, et al. Informative value of two obesity markers, body mass index (BMI) and lipid accumulation product (LAP), for assessing atherogenic risks in lipid profile: comparative analysis. Health. 2022;3:160.

Google Scholar 

Zhang H. The association between FTO, MC4R variants and obesity in different populations and the possible reasons. In Proceedings of the 1st international conference on health big data and intelligent healthcare, issue 1, pp  437–442. 2022.

Veerabathiran R, Sivakumar S, Kalarani IB, Mohammed V. A review of genes associated with obesity susceptibility: findings from association studies. J Health Sci Med Res. 2023;41(6):2023959.

Article  Google Scholar 

Golden A, Kessler C. Obesity and genetics. J Am Assoc Nurse Pract. 2020;32(7):493–6.

Article  PubMed  Google Scholar 

Lee J-E, Schmidt H, Lai B, Ge K. Transcriptional and epigenomic regulation of adipogenesis. Mol Cell Biol. 2019;39(11):e00601–18.

Article  PubMed  PubMed Central  Google Scholar 

Merrett JE, Bo T, Psaltis PJ, Proud CG. Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ and MAP kinase-interacting kinases during early adipogenesis. Adipocyte. 2020;9(1):427–42.

Article  PubMed  PubMed Central  Google Scholar 

Rivera-Íñiguez I, González-Becerra K, Ramos-Lopez O, Peréz-Beltrán YE, Chagüén-Hernández MS, Martínez-López E, et al. Lipid-related genetic variants for personalized dietary interventions: a systematic review. Mol Nutr Food Res. 2023;67(14):2200675.

Article  Google Scholar 

Madiehe AM. Glucocorticoid regulation of the leptin receptor signaling system in the rat. Louisiana State University and Agricultural & Mechanical College; 2000.

Civelek M, Wu Y, Pan C, Raulerson CK, Ko A, He A, et al. Genetic regulation of adipose gene expression and cardio-metabolic traits. Am J Hum Genet. 2017;100(3):428–43.

Article  PubMed  PubMed Central  Google Scholar 

Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:1–13.

Article  Google Scholar 

Ghobadi MZ, Afsaneh E, Emamzadeh R, Soroush M. Potential miRNA-gene interactions determining progression of various ATLL cancer subtypes after infection by HTLV-1 oncovirus. BMC Med Genom. 2023;16(1):62.

Article  Google Scholar 

Salih SJ, Ghobadi MZ. Evaluating the cytotoxicity and pathogenicity of multi-walled carbon nanotube through weighted gene co-expression network analysis: a nanotoxicogenomics study. BMC Genomic Data. 2022;23(1):12.

Article  PubMed  PubMed Central  Google Scholar 

Zarei Ghobadi M, Afsaneh E, Emamzadeh R. Gene biomarkers and classifiers for various subtypes of HTLV-1-caused ATLL cancer identified by a combination of differential gene co-expression and support vector machine algorithms. Med Microbiol Immunol. 2023;212(4):263–70.

Article  PubMed  Google Scholar 

Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, et al. The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic Acids Res. 2021;49(D1):D605–12.

Article  PubMed  Google Scholar 

Chen Y, Wang X. miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res. 2020;48(D1):D127–31.

Article  PubMed  Google Scholar 

Zarei Ghobadi M, Emamzadeh R, Teymoori-Rad M, Afsaneh E. Exploration of blood-derived coding and non-coding RNA diagnostic immunological panels for COVID-19 through a co-expressed-based machine learning procedure. Front Immunol. 2022;13: 1001070.

Article  PubMed  PubMed Central  Google Scholar 

Wu L, Zhang L, Li B, Jiang H, Duan Y, Xie Z, et al. AMP-activated protein kinase (AMPK) regulates energy metabolism through modulating thermogenesis in adipose tissue. Front Physiol. 2018;9: 330736.

Article  Google Scholar 

Jin H, Li D, Wang X, Jia J, Chen Y, Yao Y, et al. VEGF and VEGFB play balancing roles in adipose differentiation, gene expression, and function. Endocrinology. 2018;159(5):2036–49.

Article  PubMed  Google Scholar 

Luglio HF, Sulistyoningrum DC, Susilowati R. The role of genes involved in lipolysis on weight loss program in overweight and obese individuals. J Clin Biochem Nutr. 2015;57(2):91–7.

Article  PubMed  PubMed Central  Google Scholar 

Loid P, Mustila T, Mäkitie RE, Viljakainen H, Kämpe A, Tossavainen P, et al. Rare variants in genes linked to appetite control and hypothalamic development in early-onset severe obesity. Front Endocrinol. 2020;11: 512622.

Article  Google Scholar 

Grahame HD. AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease. J Intern Med. 2014;276(6):543–59.

Article  Google Scholar 

Sharma RK, Chafik A, Bertolin G. Aurora kinase A/AURKA functionally interacts with the mitochondrial ATP synthase to regulate energy metabolism and cell death. Cell Death Discov. 2023;9(1):203.

Article  PubMed  PubMed Central  Google Scholar 

Bonora M, Patergnani S, Rimessi A, De Marchi E, Suski JM, Bononi A, et al. ATP synthesis and storage. Purinergic Signal. 2012;8:343–57.

Article  PubMed  PubMed Central  Google Scholar 

Soikkeli J, Podlasz P, Yin M, Nummela P, Jahkola T, Virolainen S, et al. Metastatic outgrowth encompasses COL-I, FN1, and POSTN Up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth. Am J Pathol. 2010;177(1):387–403.

Article  PubMed  PubMed Central  Google Scholar 

Jääskeläinen I, Petäistö T, Mirzarazi Dahagi E, Mahmoodi M, Pihlajaniemi T, Kaartinen MT, et al. Collagens Regulating Adipose Tissue Formation and Functions. Biomedicines. 2023;11(5):1412.

Jones JEC, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, et al. The adipocyte acquires a fibroblast-like transcriptional signature in response to a high fat diet. Sci Rep. 2020;10(1):2380.

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhao M, Zhang Y. Identification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated bioinformatic analysis. Bioengineered. 2021;12(1):5386–401.

Article  PubMed  PubMed Central  Google Scholar 

Zeng X, Cao Z, Luo W, Zheng L, Zhang T. MicroRNA-381-A Key transcriptional regulator: its biological function and clinical application prospects in cancer. Front Oncol. 2020;10: 535665.

Article  PubMed  PubMed Central  Google Scholar 

Jiang X, Yu M, Zhu T, Lou L, Chen X, Li Q, et al. Emerging Role of Kcnq1ot1/miR-381–3p/ETS2 Signaling Axis in Inflammation of Acute Respiratory Distress Syndrome. Available at SSRN 3377519. 2019.

Millward D. Protein: Synthesis and Turnover. 2013.

Roustai Geraylow K, Hemmati R, Kadkhoda S, Ghafouri-Fard S. miRNA expression in COVID-19. Gene Rep. 2022;28. 101641

Article  PubMed  PubMed Central  Google Scholar 

Adriana Balderas-Peña, L-M, Sat-Muñoz D, Mireles-Ramírez M-A, Martínez-Herrera B-E, Nava-Zavala A-H, Cervantes-González L-M, et al. Influence of chronic low-grade inflammation (obesity) on the systemic inflammatory response. In: Padilla-Raygoza N, editor. Multisystem inflammatory syndrome. Rijeka: IntechOpen; 2023. p. Ch. 5.

Stansbury CM, Dotson GA, Pugh H, Rehemtulla A, Rajapakse I, Muir LA. A lipid-associated macrophage lineage rewires the spatial landscape of adipose tissue in early obesity. JCI Insight. 2023;8(19):e171701.

留言 (0)

沒有登入
gif