Summerfield SG, Yates JWT, Fairman DA. Free drug theory - no longer just a hypothesis? Pharm Res. 2022;39(2):213–22.

Article  CAS  PubMed  Google Scholar 

Greenblatt DJ, Bruno CD, Harmatz JS, Zhang QC, Chow CR. Drug disposition in subjects with obesity: the research work of Darrell R. Abernethy J Clin Pharmacol. 2022;62(11):1350–63.

Article  CAS  PubMed  Google Scholar 

Musteata FM. Calculation of normalized drug concentrations in the presence of altered plasma protein binding. Clin Pharmacokinet. 2012;51(1):55–68.

Article  CAS  PubMed  Google Scholar 

Svennebring AM. The impact of the concentration of drug binding plasma proteins on drug distribution according to Oie–Tozer’s model. Xenobiotica. 2016;46(4):307–14.

Article  CAS  PubMed  Google Scholar 

Greenblatt DJ, Sellers EM, Koch-Weser J. Importance of protein binding for the interpretation of serum or plasma drug concentrations. J Clin Pharmacol. 1982;22(5–6):259–63.

Article  CAS  PubMed  Google Scholar 

Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Clin Pharmacol Therap. 2002;71(3):115–21.

Article  CAS  Google Scholar 

Tatlow D. Jekyll and Hyde of chemotherapy treatment: method for patient-specific dosing of chemotherapy medications. Clin Exp Pharmacol Physiol. 2018;45(3):312–6.

Article  CAS  PubMed  Google Scholar 

Roberts JA, Pea F, Lipman J. The clinical relevance of plasma protein binding changes. Clin Pharmacokinet. 2013;52(1):1–8.

Article  CAS  PubMed  Google Scholar 

Schmidt S, Gonzalez D, Derendorf H. Significance of protein binding in pharmacokinetics and pharmacodynamics. J Pharm Sci. 2010;99(3):1107–22.

Article  CAS  PubMed  Google Scholar 

Celestin MN, Musteata FM. Impact of changes in free concentrations and drug-protein binding on drug dosing regimens in special populations and disease states. J Pharm Sci. 2021;110(10):3331–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balaz S. Subcellular pharmacokinetics: one-compartment model. Am J Pharm Educ. 2002;66(1):66–71.

Google Scholar 

Balaz S. Modeling kinetics of subcellular disposition of chemicals. Chem Rev. 2009;109(5):1793–899.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balaz S, Wiese M, Seydel JK. A time hierarchy-based model for kinetics of drug disposition and its use in quantitative structure-activity relationships. J Pharm Sci. 1992;81(9):849–57.

Article  CAS  PubMed  Google Scholar 

Moore JE Jr, Bertram CD. Lymphatic system flows. Annual Rev Fluid Mech. 2018;50:459–82.

Article  Google Scholar 

Moman RN, Gupta N, Varacallo M. Physiology, Albumin. StatPearls. Treasure Island (FL): StatPearls Publishing, Copyright© 2024. 2024.

Wang Y, Lang L, Huang P, Wang Z, Jacobson O, Kiesewetter DO, et al. In vivo albumin labeling and lymphatic imaging. Proc Natl Acad Sci USA. 2015;112(1):208–13.

Article  PubMed  Google Scholar 

Rutili G, Arfors KE. Protein concentration in interstitial and lymphatic fluids from the subcutaneous tissue. Acta Physiol Scand. 1977;99(1):1–8.

Article  CAS  PubMed  Google Scholar 

Hahn RG, Dull RO. Interstitial washdown and vascular albumin refill during fluid infusion: novel kinetic analysis from three clinical trials. Intensive Care Med Exp. 2021;9(1):44.

Article  PubMed  PubMed Central  Google Scholar 

Cibotaru D, Celestin MN, Kane MP, Musteata FM. Method for simultaneous determination of free concentration, total concentration, and plasma binding capacity in clinical samples. J Pharm Sci. 2021;110(3):1401–11.

Article  CAS  PubMed  Google Scholar 

Stepensky D. The Øie–Tozer model of drug distribution and its suitability for drugs with different pharmacokinetic behavior. Expert Opin Drug Metab Toxicol. 2011;7(10):1233–43.

Article  CAS  PubMed  Google Scholar 

Stepensky D. Use of unbound volumes of drug distribution in pharmacokinetic calculations. Eur J Pharm Sci. 2011;42(1–2):91–8.

Article  CAS  PubMed  Google Scholar 

Al-Qassabi J, Tan SPF, Phonboon P, Galetin A, Rostami-Hodjegan A, Scotcher D. Facing the facts of altered plasma protein binding: do current models correctly predict changes in fraction unbound in special populations? J Pharm Sci. 2024;113(6):1664–73.

Article  CAS  PubMed  Google Scholar