Baek J, Jeong H, Ham Y, Hee Jo YH, Choi M, Kang M, Son B, Choi S, Ruy HW, Kim J, Shen H, Sydara K, Lee SW, Kim SY, Han SB, Oh SR, Cho S (2019) Improvement of spinal muscular atrophy via correction of the SMN2 splicing defect by Brucea javanica (L.) Merr. extract and bruceine D. Phytomedicine 65:153089. https://doi.org/10.1016/j.phymed.2019.153089
Bawm S, Matsuura H, Elkhateeb A, Nabeta K, Subeki NN, Oku Y, Katakura K (2008) In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica. Vet Parasitol 158:288–294. https://doi.org/10.1016/j.vetpar.2008.09.021
Article CAS PubMed Google Scholar
Chen H, Bai J, Fang ZF, Yu SS, Ma SG, Xu S, Li Y, Qu J, Ren JH, Li L, Si YK, Chen XG (2011) Indole alkaloids and quassinoids from the stems of Brucea mollis. J Nat Prod 74:2438–2445. https://doi.org/10.1021/np200712y
Article CAS PubMed Google Scholar
Chen D, Li K, Wang B, Chen H, Jiang H, Zhao C, Yao G, Li S, Xu H (2023) Bruceine D acts as a potential insecticide by antagonizing 20E−EcR/USP signal transduction. J Agric Food Chem 71:11491–11501. https://doi.org/10.1021/acs.jafc.3c02275
Article CAS PubMed Google Scholar
Chen H, Han X, Zhang Y, Wang K, Liu D, Hu Z, Wang J (2024) Bruceine D suppresses CAF-promoted TNBC metastasis under TNF-α stimulation by inhibiting Notch1-Jagged1/NF-κB(p65) signaling. Phytomedicine 123:154928. https://doi.org/10.1016/j.phymed.2023.154928
Article CAS PubMed Google Scholar
Cheng Z, Yuan X, Qu Y, Li X, Wu G, Li C, Zu X, Yang N, Ke X, Zhou J, Xie N, Xu X, Liu S, Shen Y, Li H, Zhang W (2017) Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett 403:195–205. https://doi.org/10.1016/j.canlet.2017.06.014
Article CAS PubMed Google Scholar
Chumkaew P, Pechwang J, Srisawat T (2017) Two new antimalarial quassinoid derivatives from the stems of Brucea javanica. J Nat Med 71(3):570–573. https://doi.org/10.1007/s11418-017-1089-2
Article CAS PubMed Google Scholar
Dongju Q, Xiamuxiya A, Huling P, Qian S, Xiaojuan Z (2020) Effect of bruceine D on microRNA-155 expression and proliferation and apoptosis of human retinoblastoma cells. Nanosci Nanotech Let 12:178–183. https://doi.org/10.1166/nnl.2020.3094
Dou YX, Zho JT, Wang TT, Huang YF, Chen VP, Xie YL, Lin ZX, Gao JS, Su ZR, Zeng HF (2018) Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis. Int J Nanomed 28(13):5887–5907. https://doi.org/10.2147/IJN.S174146
Elkhateeb A, Tosa Y, Matsuura H, Nabeta K, Katakura K (2011) Antitrypanosomal activities of acetylated bruceines A and C; a structure-activity relationship study. J Nat Med 66:233–240. https://doi.org/10.1007/s11418-011-0571-5
Article CAS PubMed Google Scholar
Fan J, Dongmei Ren D, Jinxia Wang J, Xiaoqing Liu X, Huaran Zhang H, Mingsheng WuM, Guotao Yang G (2020) Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo. Cell Death Dis 11:126. https://doi.org/10.1038/s41419-020-2317-3
Article CAS PubMed PubMed Central Google Scholar
Feng L, Yu Z, Yong H, Xiaoyan L, Xuan Z, Xue L, Hailin Y (2023) Effects of KCNQ1OT1 gene knockout combined with bruceine d on proliferation, migration, and invasion of breast cancer MDA-MB-231 cells. Cancer Res Prev Treat 50:1066–1074. https://doi.org/10.3971/j.issn.1000-8578.2023.23.0456
Gao Z, Yan Zhang Y, Weixing Shen W, Xinyu Liu X, Yunfang Wei Y, Linxia Li L, Hengguan Cui H (2024) Bruceine A inhibited breast cancer proliferation and metastasis by inducing autophagy via targeting PI3K-AKT signaling pathway. Chem Biol Drug Des 103:e14398. https://doi.org/10.1111/cbdd.14398
Article CAS PubMed Google Scholar
Ha NM, Son NT (2024) Health benefits of fraxetin: from chemistry to medicine. Arch Pharm e2400092. https://doi.org/10.1002/ardp.202400092
He X, Wu J, Tan T, Guo W, Xiong Z, Yang S, Feng Y, Wen Q (2021) Quassinoids from Brucea javanica and attenuates lipopolysaccharide-induced acute lung injury by inhibiting PI3K/Akt/NF-κB pathways. Fitoterapia 153:104980. https://doi.org/10.1016/j.fitote.2021.104980
Article CAS PubMed Google Scholar
Huang R, Zhang L, Jin J, Zhou Y, Zhang H, Lv C, Lu D, Wu Y, Zhang H, Liu S, Chen H, Luan X, Zhang W (2021) Bruceine D inhibits HIF-1 α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/ β-catenin interaction. Acta Pharm Sin B 11:3481–3492. https://doi.org/10.1016/j.apsb.2021.05.009
Article CAS PubMed PubMed Central Google Scholar
Huong DTL, Son NT (2024) Pristimerin: Natural occurrence, biosynthesis, pharmacology, and pharmacokinetics. Rev Bras Farmacogn 34:467–480. https://doi.org/10.1007/s43450-024-00520-z
Kirby GC, O’Neill MJ, Phillipson JD, Warhurst DC (1989) In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum. Biochem Pharmacol 38:4367–4374. https://doi.org/10.1016/0006-2952(89)90644-8
Article CAS PubMed Google Scholar
Li L, Dong Z, Shi P, Tan L, Xu J, Huang P, Wang Z, Cui H, Yang L (2020) Bruceine D inhibits cell proliferation through downregulating LINC01667/MicroRNA-138-5p/Cyclin E1 axis in gastric cancer. Front Pharmacol 24(11):584960. https://doi.org/10.3389/fphar.2020.584960
Li K, Liang Y, Wang Q, Li Y, Zhou S, Wei H, Zhou C, Wan X (2021) Brucea javanica: a review on anticancer of its pharmacological properties and clinical researches. Phytomedicine 86:153560. https://doi.org/10.1016/j.phymed.2021.153560
Article CAS PubMed Google Scholar
Li J, Zheng D, Wei N, Sun Y, Liu L, Yuan Y, Jiang Q (2022) A new quassinoid from Brucea javanica. Chem Nat Compd 58:553–555. https://doi.org/10.1007/s10600-022-03762-2
Li X, Liu C, Zhang X, Sun C, Ling J, Liu Y, Zuo Y, Cao Y, Zhang C, Jiang T, Wang M, Liu J, Lu J (2023a) Bruceine A: suppressing metastasis via MEK/ERK pathway and invoking mitochondrial apoptosis in triple-negative breast cancer. Biomed Pharmacother 168:115784. https://doi.org/10.1016/j.biopha.2023.115784
Article CAS PubMed Google Scholar
Li H, Zhao X, Zheng L, Wang X, Lin S, Shen J, Ren H, Li Y, Qiu Q, Wang Z (2023b) Bruceine A protects against diabetic kidney disease via inhibiting galectin-1. Kidney Int 102:521–535. https://doi.org/10.1016/j.kint.2022.04.020
Li H, Zhu X, Sun Z, Wang Q, Song S, Xu Y, He G, Mao X (2024a) Bruceine B displays potent antimyeloma activity by inducing the degradation of the transcription factor c-Maf. ACS Pharmacol Transl Sci 71:176–185. https://doi.org/10.1021/acsptsci.3c00222
Li L, Xu S, Wang W, Li X, Wang H, Yang Q et al (2024b) Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR. Phytomedicine 130:155693. https://doi.org/10.1016/j.phymed.2024.155693
Article CAS PubMed Google Scholar
Liu JQ, Wang CF, Li XY, Chen JC, Li Y, Qiu MH (2011) One new pregnane glycoside from the seeds of cultivated Brucea javanica. Arch Pharm Res 34:1297–1300. https://doi.org/10.1007/s12272-011-0809-5
Article CAS PubMed Google Scholar
Liuliu P, Feiyun Z, Haiyan Z, Shenghui Z, Yan H (2015) The effect of bruceine D on high-risk human papillomavirus 16 infected cell and its possible mechanism. J Wenzhou Med Univ 45:89−94
Lu C, Fan L, Zhang PF, Tao WW, Yang CB, Shang EX, Chen FY, Che CT, Cheng HB, Duan JA, Zhao M (2021) A novel P38α MAPK activator bruceine A exhibits potent anti-pancreatic cancer activity. Comput Struct Biotechnol J 19:3437–3450. https://doi.org/10.1016/j.csbj.2021.06.011
Article CAS PubMed PubMed Central Google Scholar
Luo C, Wang Y, Wei C, Chen Y, Ji Z (2020) The anti-migration and anti-invasion effects of bruceine D in human triple-negative breast cancer MDA-MB-231 cells. Exp Ther Med 19:273–279. https://doi.org/10.3892/etm.2019.8187
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