Survival prospects following SARS-CoV-2 infection extend beyond the acute phase, influenced by various factors including age, health conditions, and infection severity. We investigated mortality risk among 651 post-acute COVID-19 patients, assessing the association between urinary peptides and future death. Data spanning until December 2023 were collected from six countries, comparing mortality trends with age- and sex-matched non-infected controls. A death prediction classifier was developed and validated using pre-existing urinary peptidomics datasets. Notably, 13.98% of post-COVID-19 patients succumbed during the follow-up, with mortality rates significantly higher than non-infected controls, particularly evident in younger individuals (<65 years). Urinary peptide analysis identified 201 peptides linked to mortality, integrated into a predictive classifier (DP201). Higher DP201 scores, alongside age and BMI, significantly predicted death. These findings underscore the utility of urinary peptides in prognosticating post-acute COVID-19 mortality, offering insights for targeted interventions.
Competing Interest StatementH.M. the co-founder and co-owner of Mosaiques Diagnostics. J.S. is employed by Mosaiques-Diagnostics GmbH.
Funding StatementThis project was supported by Federal Ministry of Health (BMG) via grant number 25323FSB114; by the German ministry for education and science (BMBF), via grant 01KU2309; by the Swedish governmental agency for innovation systems (Vinnova), via gran 2022-00542; by National Centre for Research and Development (Narodowe Centrum Badań i Rozwoju), via grant number: PerMed/V/162/UriCov/2023; by Austrian Science Fund (FWF) via Project number I 6464, Grant-DOI 10.55776/I6464; and by the French National Research Agency Agence Nationale de la Recherche (ANR), under the grant ANR-22-PERM-0014 and in part by Austrian Science Fund (FWF) via Project number I 6471, Grant-DOI 10.55776/I6471 under the frame of ERA PerMed.
Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
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The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
The Ethics Committee of the German-Saxonian Board of Physicians (Dresden, Germany; number EK-BR-70/23-1) and the Institutional Review Boards of the recruiting sites provided ethical approval
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Data AvailabilityThe data that support the findings of this study are available upon request from the corresponding author
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