Li S, Xu H-X, Wu C-T, Wang W-Q, et al. Angiogenesis in pancreatic cancer: current research status and clinical implications. Angiogenesis. 2019;22(1):15–36.
Lal JC. Deconvoluting cellular neighborhoods in pancreatic ductal adenocarcinoma. Commun Biology. 2022;5(1):1099.
Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221:107753.
Article CAS PubMed Google Scholar
Chen Y-P, Lv J-W, Mao Y-P, Li X-M, Li J-Y, Wang Y-Q, et al. Unraveling Tumour Microenvironment Heterogeneity in Nasopharyngeal Carcinoma identifies biologically distinct Immune subtypes Predicting prognosis and immunotherapy responses. Mol Cancer. 2021;20(1):14.
Article CAS PubMed PubMed Central Google Scholar
Ahmed R, Zaman T, Chowdhury F, Mraiche F, Tariq M, Ahmad IS, Hasan A. Single-cell RNA sequencing with spatial transcriptomics of Cancer tissues. Int J Mol Sci. 2022;23(6):3042.
Article CAS PubMed PubMed Central Google Scholar
Maruggi M, Layng FI, Lemos R, Garcia J, James G, Sevilla BP, Soldevilla M, Baaten F, Jong BJ, de Koh PR, M. Y., Powis G. Absence of HIF1A leads to glycogen accumulation and an inflammatory response that enables pancreatic tumor growth. Cancer Res. 2019;79(22):5839. https://doi.org/10.1158/0008-5472.CAN-18-2994.
Article CAS PubMed PubMed Central Google Scholar
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, et al. A revised classification system and recommendations from the Baltimore Consensus Meeting for neoplastic precursor lesions in the pancreas. Am J Surg Pathol. 2015;39:1730–41.
Article PubMed PubMed Central Google Scholar
Liu J, Qu S, Zhang T, Gao Y, Shi H, Song K, Chen W, Yin W. Applications of single-cell omics in Tumor Immunology. Front Immunol. 2021;12:697412. https://doi.org/10.3389/fimmu.2021.697412.
Article CAS PubMed PubMed Central Google Scholar
Labani-Motlagh A, Ashja-Mahdavi M, Loskog A. The Tumor Microenvironment: a Milieu Hindering and Obstructing Antitumor Immune responses. Front Immunol. 2020;11:940.
Article CAS PubMed PubMed Central Google Scholar
Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, et al. Understanding the Tumor Immune Microenvironment (Time) for effective therapy. Nat Med. 2018;24:541–50.
Article CAS PubMed PubMed Central Google Scholar
Petitprez F, Meylan M, de Reynies A, Sautes-Fridman C, Fridman WH. The Tumor Microenvironment in the response to Immune Checkpoint Blockade therapies. Front Immunol. 2020;11:784.
Article CAS PubMed PubMed Central Google Scholar
Yousuf S, Qiu M, von Voithenberg LV et al. Spatially resolved multi-omics single-cell analyses inform mechanisms of immune-dysfunction in pancreatic cancer. Gastroenterology. Published online May 30, 2023:S0016-5085(23)00810-7. https://doi.org/10.1053/j.gastro.2023.05.036.
Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, et al. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet. 2022;54(9):1390–405.
Article CAS PubMed PubMed Central Google Scholar
Aziz HM, Saida L, de Koning W, Stubbs AP, Li Y, Sideras K, Palacios E, Feliu J, Mendiola M, van Eijck CHJ, Mustafa DAM. Spatial genomics reveals a high number and specific location of B cells in the pancreatic ductal adenocarcinoma microenvironment of long-term survivors. Front Immunol. 2023;13:995715.
Article PubMed PubMed Central Google Scholar
Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: IARC; 2010.
Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, Caravan W, Sato K, Storrs E, Mo C-K, Liu J, Southard-Smith AN, Wu Y, Deen NA, Baer N, Fulton JM, Wyczalkowski RS, Liu MA, Ding R, L. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet. 2022;54(9):1390–405. https://doi.org/10.1038/s41588-022-01157-1.
Article CAS PubMed PubMed Central Google Scholar
Schalck A, Sakellariou-Thompson D, Forget MA, Sei E, Hughes TG, Reuben A, et al. Single-cell sequencing reveals trajectory of tumor-infiltrating lymphocyte states in pancreatic cancer. Cancer Discov. 2022;12:2330–49. https://doi.org/10.1158/2159-8290.CD-21-1248.
Article CAS PubMed PubMed Central Google Scholar
Potter SS. Single-cell RNA sequencing for the study of development, physiology and disease. Nat Rev Nephrol. 2018;14:479–92. https://doi.org/10.1038/s41581-018-0021-7.
Article CAS PubMed PubMed Central Google Scholar
Casado-Pelaez M, Bueno-Costa A, Esteller M. Single cell cancer epigenetics. Trends Cancer. 2022;8:820–38. https://doi.org/10.1016/j.trecan.2022.06.005.
Article CAS PubMed Google Scholar
Chen TY, You L, Hardillo JAU, Chien MP. Spat Transcriptomic Technol Cells.2023;12(16).
Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity. 2019;50(5):1317–34.
Article CAS PubMed PubMed Central Google Scholar
Baslan T, Hicks J. Unravelling biology and shifting paradigms in cancer with single-cell sequencing. Nat Rev Cancer. 2017;17(9):557–69.
Article CAS PubMed Google Scholar
Pan Y, Lu F, Fei Q, Yu X, Xiong P, Yu X, et al. Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer. J Hematol Oncol. 2019;12:124. https://doi.org/10.1186/s13045-019-0822-6.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, Wang D, Peng M, Tang L, Ouyang J, Xiong F, Guo C, Tang Y, Zhou Y, Liao Q, Wu X, Wang H, Yu J, Li Y, Li X, Li G, Zeng Z, Tan Y, Xiong W. Single-cell RNA sequencing in cancer research. J Experimental Clin Cancer Research: CR. 2021;40(1):81. https://doi.org/10.1186/s13046-021-01874-1.
Article CAS PubMed Central Google Scholar
Sun H, Zhang D, Huang C, Guo Y, Yang Z, Yao N, Dong X, Cheng R, Zhao N, Meng J, Sun B, Hao J. Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer. Cancer Biology Med. 2021;18(2):616–30.
Huang H, Brekken RA. Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer. Am J Physiol - Cell Physiol. 2020;319(2):C233–43.
Article CAS PubMed PubMed Central Google Scholar
Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA. Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2017;16:2473–85.
Article CAS PubMed PubMed Central Google Scholar
Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, et al. Mapping the mouse cell atlas by Microwell-Seq. Cell. 2018;172(5):1091–107.
Article CAS PubMed Google Scholar
Lei Y, Tang R, Xu J, et al. Applications of single-cell sequencing in cancer research: progress and perspectives. J Hematol OncolJ Hematol Oncol. 2021;14:91.
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