Progress of single-cell RNA sequencing combined with spatial transcriptomics in tumour microenvironment and treatment of pancreatic cancer

Li S, Xu H-X, Wu C-T, Wang W-Q, et al. Angiogenesis in pancreatic cancer: current research status and clinical implications. Angiogenesis. 2019;22(1):15–36.

Article  PubMed  Google Scholar 

Lal JC. Deconvoluting cellular neighborhoods in pancreatic ductal adenocarcinoma. Commun Biology. 2022;5(1):1099.

Article  Google Scholar 

Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221:107753.

Article  CAS  PubMed  Google Scholar 

Chen Y-P, Lv J-W, Mao Y-P, Li X-M, Li J-Y, Wang Y-Q, et al. Unraveling Tumour Microenvironment Heterogeneity in Nasopharyngeal Carcinoma identifies biologically distinct Immune subtypes Predicting prognosis and immunotherapy responses. Mol Cancer. 2021;20(1):14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmed R, Zaman T, Chowdhury F, Mraiche F, Tariq M, Ahmad IS, Hasan A. Single-cell RNA sequencing with spatial transcriptomics of Cancer tissues. Int J Mol Sci. 2022;23(6):3042.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maruggi M, Layng FI, Lemos R, Garcia J, James G, Sevilla BP, Soldevilla M, Baaten F, Jong BJ, de Koh PR, M. Y., Powis G. Absence of HIF1A leads to glycogen accumulation and an inflammatory response that enables pancreatic tumor growth. Cancer Res. 2019;79(22):5839. https://doi.org/10.1158/0008-5472.CAN-18-2994.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, et al. A revised classification system and recommendations from the Baltimore Consensus Meeting for neoplastic precursor lesions in the pancreas. Am J Surg Pathol. 2015;39:1730–41.

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Qu S, Zhang T, Gao Y, Shi H, Song K, Chen W, Yin W. Applications of single-cell omics in Tumor Immunology. Front Immunol. 2021;12:697412. https://doi.org/10.3389/fimmu.2021.697412.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Labani-Motlagh A, Ashja-Mahdavi M, Loskog A. The Tumor Microenvironment: a Milieu Hindering and Obstructing Antitumor Immune responses. Front Immunol. 2020;11:940.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, et al. Understanding the Tumor Immune Microenvironment (Time) for effective therapy. Nat Med. 2018;24:541–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Petitprez F, Meylan M, de Reynies A, Sautes-Fridman C, Fridman WH. The Tumor Microenvironment in the response to Immune Checkpoint Blockade therapies. Front Immunol. 2020;11:784.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yousuf S, Qiu M, von Voithenberg LV et al. Spatially resolved multi-omics single-cell analyses inform mechanisms of immune-dysfunction in pancreatic cancer. Gastroenterology. Published online May 30, 2023:S0016-5085(23)00810-7. https://doi.org/10.1053/j.gastro.2023.05.036.

Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, et al. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet. 2022;54(9):1390–405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aziz HM, Saida L, de Koning W, Stubbs AP, Li Y, Sideras K, Palacios E, Feliu J, Mendiola M, van Eijck CHJ, Mustafa DAM. Spatial genomics reveals a high number and specific location of B cells in the pancreatic ductal adenocarcinoma microenvironment of long-term survivors. Front Immunol. 2023;13:995715.

Article  PubMed  PubMed Central  Google Scholar 

Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of tumours of the digestive system. Lyon: IARC; 2010.

Google Scholar 

Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, Caravan W, Sato K, Storrs E, Mo C-K, Liu J, Southard-Smith AN, Wu Y, Deen NA, Baer N, Fulton JM, Wyczalkowski RS, Liu MA, Ding R, L. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet. 2022;54(9):1390–405. https://doi.org/10.1038/s41588-022-01157-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schalck A, Sakellariou-Thompson D, Forget MA, Sei E, Hughes TG, Reuben A, et al. Single-cell sequencing reveals trajectory of tumor-infiltrating lymphocyte states in pancreatic cancer. Cancer Discov. 2022;12:2330–49. https://doi.org/10.1158/2159-8290.CD-21-1248.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Potter SS. Single-cell RNA sequencing for the study of development, physiology and disease. Nat Rev Nephrol. 2018;14:479–92. https://doi.org/10.1038/s41581-018-0021-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casado-Pelaez M, Bueno-Costa A, Esteller M. Single cell cancer epigenetics. Trends Cancer. 2022;8:820–38. https://doi.org/10.1016/j.trecan.2022.06.005.

Article  CAS  PubMed  Google Scholar 

Chen TY, You L, Hardillo JAU, Chien MP. Spat Transcriptomic Technol Cells.2023;12(16).

Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity. 2019;50(5):1317–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baslan T, Hicks J. Unravelling biology and shifting paradigms in cancer with single-cell sequencing. Nat Rev Cancer. 2017;17(9):557–69.

Article  CAS  PubMed  Google Scholar 

Pan Y, Lu F, Fei Q, Yu X, Xiong P, Yu X, et al. Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer. J Hematol Oncol. 2019;12:124. https://doi.org/10.1186/s13045-019-0822-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Wang D, Peng M, Tang L, Ouyang J, Xiong F, Guo C, Tang Y, Zhou Y, Liao Q, Wu X, Wang H, Yu J, Li Y, Li X, Li G, Zeng Z, Tan Y, Xiong W. Single-cell RNA sequencing in cancer research. J Experimental Clin Cancer Research: CR. 2021;40(1):81. https://doi.org/10.1186/s13046-021-01874-1.

Article  CAS  PubMed Central  Google Scholar 

Sun H, Zhang D, Huang C, Guo Y, Yang Z, Yao N, Dong X, Cheng R, Zhao N, Meng J, Sun B, Hao J. Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer. Cancer Biology Med. 2021;18(2):616–30.

Article  CAS  Google Scholar 

Huang H, Brekken RA. Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer. Am J Physiol - Cell Physiol. 2020;319(2):C233–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aguilera KY, Huang H, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA. Inhibition of discoidin domain receptor 1 reduces collagen-mediated tumorigenicity in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2017;16:2473–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han X, Wang R, Zhou Y, Fei L, Sun H, Lai S, et al. Mapping the mouse cell atlas by Microwell-Seq. Cell. 2018;172(5):1091–107.

Article  CAS  PubMed  Google Scholar 

Lei Y, Tang R, Xu J, et al. Applications of single-cell sequencing in cancer research: progress and perspectives. J Hematol OncolJ Hematol Oncol. 2021;14:91.

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