An essential gene signature of breast cancer metastasis reveals targetable pathways

Yu Z, Song M, Chouchane L, Ma X. Functional genomic analysis of breast cancer metastasis: implications for diagnosis and therapy. Cancers (Basel). 2021;13(13):3276.

Article  CAS  PubMed  Google Scholar 

Nathanson S, Detmar M, Padera T, Yates L, Welch D, Beadnell T, Scheid A, Wrenn E, Cheung K. Mechanisms of breast cancer metastasis. Clin Exp Metastasis. 2022;39(1):117–37.

Article  PubMed  Google Scholar 

Park M, Kim D, Ko S, Kim A, Mo K, Yoon H. Breast cancer metastasis: mechanisms and therapeutic implications. Int J Mol Sci. 2022;23(12):6806.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aftimos P, Oliveira M, Irrthum A, Fumagalli D, Sotiriou C, Gal-Yam E, Robson M, Ndozeng J, Di Leo A, Ciruelos E, et al. Genomic and transcriptomic analyses of breast cancer primaries and matched metastases in AURORA, the Breast International Group (BIG) molecular screening initiative. Cancer Discov. 2021;11(11):2796–811.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Recio S, Hinoue T, Wheeler G, Kelly B, Garrido-Castro A, Pascual T, De Cubas A, Xia Y, Felsheim B, McClure M, et al. Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis. Nat Cancer. 2023;4(1):128–47.

CAS  PubMed  Google Scholar 

Zhang Y, Chen F, Creighton C. Pan-cancer molecular subtypes of metastasis reveal distinct and evolving transcriptional programs. Cell Rep Med. 2023;4:100932.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iwamoto T, Niikura N, Ogiya R, Yasojima H, Watanabe K, Kanbayashi C, Tsuneizumi M, Matsui A, Fujisawa T, Iwasa T, et al. Distinct gene expression profiles between primary breast cancers and brain metastases from pair-matched samples. Sci Rep. 2019;9(1):13343.

Article  PubMed  PubMed Central  Google Scholar 

Garcia-Recio S, Thennavan A, East M, Parker J, Cejalvo J, Garay J, Hollern D, He X, Mott K, Galván P, et al. FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease. J Clin Invest. 2020;130(9):4871–87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang M, Liu Z, Aoshima K, Cai W, Sun H, Xu T, Zhang Y, An Y, Chen J, Chan L, et al. CECR2 drives breast cancer metastasis by promoting NF-κB signaling and macrophage-mediated immune suppression. Sci Transl Med. 2022;14(630):eabf5473.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cosgrove N, Varešlija D, Keelan S, Elangovan A, Atkinson J, Cocchiglia S, Bane F, Singh V, Furney S, Hu C, et al. Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities. Nat Commun. 2022;13(1):514.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manso L, Mourón S, Tress M, Gómez-López G, Morente M, Ciruelos E, Rubio-Camarillo M, Rodriguez-Peralto J, Pujana M, Pisano D, et al. Analysis of paired primary-metastatic hormone-receptor positive breast tumors (HRPBC) uncovers potential novel drivers of hormonal resistance. PLoS ONE. 2016;11(5):e0155840.

Article  PubMed  PubMed Central  Google Scholar 

Klebe M, Fremd C, Kriegsmann M, Kriegsmann K, Albrecht T, Thewes V, Kirchner M, Charoentong P, Volk N, Haag J, et al. Frequent Molecular Subtype Switching and Gene Expression Alterations in Lung and Pleural Metastasis From Luminal A-Type Breast Cancer. JCO Precis Oncol. 2020;4:PO.19.00337.

PubMed  PubMed Central  Google Scholar 

Szekely B, Bossuyt V, Li X, Wali V, Patwardhan G, Frederick C, Silber A, Park T, Harigopal M, Pelekanou V, et al. Immunological differences between primary and metastatic breast cancer. Ann Oncol. 2018;29(11):2232–9.

Article  CAS  PubMed  Google Scholar 

Aran D, Sirota M, Butte A. Systematic pan-cancer analysis of tumour purity. Nat Commun. 2015;6:8971.

Article  CAS  PubMed  Google Scholar 

Joyce J, Pollard J. Microenvironmental regulation of metastasis. Nat Rev Cancer. 2009;9(4):239–52.

Article  CAS  PubMed  Google Scholar 

Wu S, Al-Eryani G, Roden D, Junankar S, Harvey K, Andersson A, Thennavan A, Wang C, Torpy J, Bartonicek N, et al. A single-cell and spatially resolved atlas of human breast cancers. Nat Genet. 2021;53(9):1334–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dempster J, Boyle I, Vazquez F, Root D, Boehm J, Hahn W, Tsherniak A, McFarland J. Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects. Genome Biol. 2021;22(1):343.

Article  PubMed  PubMed Central  Google Scholar 

Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A. 2003;100(14):8418–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

GTEx_Consortium: Genetic effects on gene expression across human tissues. Nature 2017; 550(7675), 204–213.

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf A, Angell H, Fredriksen T, Lafontaine L, Berger A, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782–95.

Article  CAS  PubMed  Google Scholar 

Tsherniak A, Vazquez F, Montgomery P, Weir B, Kryukov G, Cowley G, Gill S, Harrington W, Pantel S, Krill-Burger J, et al. Defining a Cancer Dependency Map. Cell. 2017;170(3):564–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, Matese JC, Perou CM, Hurt MM, Brown PO, et al. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell. 2002;13:1977–2000.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siegel M, He X, Hoadley K, Hoyle A, Pearce J, Garrett A, Kumar S, Moylan V, Brady C, Van Swearingen A, et al. Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer. J Clin Invest. 2018;128(4):1371–83.

Article  PubMed  PubMed Central  Google Scholar 

Chen F, Zhang Y, Varambally S, Creighton C. Molecular correlates of metastasis by systematic pan-cancer analysis across the Cancer Genome Atlas. Mol Cancer Res. 2019;17(2):476–87.

Article  CAS  PubMed  Google Scholar 

Ramaswamy S, Ross K, Lander E, Golub T. A molecular signature of metastasis in primary solid tumors. Nat Genet. 2003;33(1):49–54.

Article  CAS  PubMed  Google Scholar 

van’t Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT. Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415:530–6.

Article  PubMed  Google Scholar 

Kessler J, Kahle K, Sun T, Meerbrey K, Schlabach M, Schmitt E, Skinner S, Xu Q, Li M, Hartman Z, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012;335(6066):348–53.

Article  CAS  PubMed  Google Scholar 

Pereira B, Chin S, Rueda O, Vollan H, Provenzano E, Bardwell H, Pugh M, Jones L, Russell R, Sammut S, et al. The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. Nat Commun. 2016;7:11479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Staaf J, Häkkinen J, Hegardt C, Saal L, Kimbung S, Hedenfalk I, Lien T, Sørlie T, Naume B, Russnes H, et al. RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer. NPJ Breast Cancer. 2022;8(1):94.

Article 

留言 (0)

沒有登入
gif