Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ, Nicolls MR. Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur Respir J. 2012;40:1555–65. https://doi.org/10.1183/09031936.00046612.
Article CAS PubMed PubMed Central Google Scholar
Guignabert C, Dorfmuller P. Pathology and pathobiology of pulmonary hypertension. Semin Respir Crit Care Med. 2017;38:571–84. https://doi.org/10.1055/s-0037-1606214.
Villagra J, Shiva S, Hunter LA, Machado RF, Gladwin MT, Kato GJ. Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin. Blood. 2007;110:2166–72. https://doi.org/10.1182/blood-2006-12-061697.
Article CAS PubMed PubMed Central Google Scholar
Al-Qadi M, LeVarge B, Ford HJ. Epidemiology, pathogenesis, and clinical approach in group 5 pulmonary hypertension. Front Med (Lausanne). 2020;7:616720. https://doi.org/10.3389/fmed.2020.616720.
Simonneau G, Montani D, Celermajer DS, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53. https://doi.org/10.1183/13993003.01913-2018.
Long L, Ormiston ML, Yang X, et al. Selective enhancement of endothelial bmpr-ii with bmp9 reverses pulmonary arterial hypertension. Nat Med. 2015;21:777–85. https://doi.org/10.1038/nm.3877.
Article CAS PubMed PubMed Central Google Scholar
Liu X, Gao C, Wang Y, Niu L, Jiang S, Pan S. Bmsc-derived exosomes ameliorate lps-induced acute lung injury by mir-384-5p-controlled alveolar macrophage autophagy. Oxid Med Cell Longev. 2021; 2021: 9973457. https://doi.org/10.1155/2021/9973457.
Islam D, Huang Y, Fanelli V, et al. Identification and modulation of microenvironment is crucial for effective mesenchymal stromal cell therapy in acute lung injury. Am J Respir Crit Care Med. 2019;199:1214–24. https://doi.org/10.1164/rccm.201802-0356OC.
Article CAS PubMed Google Scholar
Morrison TJ, Jackson MV, Cunningham EK, et al. Mesenchymal stromal cells modulate macrophages in clinically relevant lung injury models by extracellular vesicle mitochondrial transfer. Am J Respir Crit Care Med. 2017;196:1275–86. https://doi.org/10.1164/rccm.201701-0170OC.
Article CAS PubMed PubMed Central Google Scholar
Prockop DJ, Oh JY. Mesenchymal stem/stromal cells (mscs): role as guardians of inflammation. Mol Ther. 2012;20:14–20. https://doi.org/10.1038/mt.2011.211.
Article CAS PubMed Google Scholar
Winiarski BK, Acheson N, Gutowski NJ, McHarg S, Whatmore JL. An improved and reliable method for isolation of microvascular endothelial cells from human omentum. Microcirculation. 2011;18:635–45. https://doi.org/10.1111/j.1549-8719.2011.00128.x.
Article CAS PubMed Google Scholar
Xu J, Xu D, Yu Z, et al. Exosomal mir-150 partially attenuated acute lung injury by mediating microvascular endothelial cells and mapk pathway. Biosci Rep. 2022;42. https://doi.org/10.1042/BSR20203363.
Glynos C, Kotanidou A, Orfanos SE, et al. Soluble guanylyl cyclase expression is reduced in lps-induced lung injury. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1448–55. https://doi.org/10.1152/ajpregu.00341.2006.
Article CAS PubMed Google Scholar
Grinnell K, Duong H, Newton J, Rounds S, Choudhary G, Harrington EO. Heterogeneity in apoptotic responses of microvascular endothelial cells to oxidative stress. J Cell Physiol. 2012;227:1899–910. https://doi.org/10.1002/jcp.22918.
Article CAS PubMed PubMed Central Google Scholar
Kerchberger VE, Bastarache JA, Shaver CM, et al. Haptoglobin-2 variant increases susceptibility to acute respiratory distress syndrome during sepsis. Jci Insight. 2019;4. https://doi.org/10.1172/jci.insight.131206.
Beckmann N, Cannet C, Karmouty-Quintana H, et al. Lung mri for experimental drug research. Eur J Radiol. 2007;64:381–96. https://doi.org/10.1016/j.ejrad.2007.08.012.
Jin Y, Qian J, Ju X et al. Osthole protects against acute lung injury by suppressing nf-kappab-dependent inflammation. Mediators Inflamm. 2018; 2018: 4934592. https://doi.org/10.1155/2018/4934592.
Qi D, Tang X, He J, et al. Omentin protects against lps-induced ards through suppressing pulmonary inflammation and promoting endothelial barrier via an akt/enos-dependent mechanism. Cell Death Dis. 2016;7:e2360. https://doi.org/10.1038/cddis.2016.265.
Article CAS PubMed PubMed Central Google Scholar
Kolliputi N, Galam L, Parthasarathy PT, Tipparaju SM, Lockey RF. Nalp-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability. J Cell Physiol. 2012;227:3310–6. https://doi.org/10.1002/jcp.24026.
Article CAS PubMed PubMed Central Google Scholar
Kuklin VN, Kirov MY, Evgenov OV, et al. Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep. Crit Care Med. 2004;32:766–73. https://doi.org/10.1097/01.ccm.0000114575.08269.f6.
Article CAS PubMed Google Scholar
Yang Y, Hu S, Xu X et al. The vascular endothelial growth factors-expressing character of mesenchymal stem cells plays a positive role in treatment of acute lung injury in vivo. Mediators Inflamm. 2016; 2016: 2347938. https://doi.org/10.1155/2016/2347938.
Yi L, Huang X, Guo F, et al. Lipopolysaccharide induces human pulmonary micro-vascular endothelial apoptosis via the yap signaling pathway. Front Cell Infect Microbiol. 2016;6:133. https://doi.org/10.3389/fcimb.2016.00133.
Article CAS PubMed PubMed Central Google Scholar
Magro CM, Allen J, Pope-Harman A, et al. The role of microvascular injury in the evolution of idiopathic pulmonary fibrosis. Am J Clin Pathol. 2003;119:556–67. https://doi.org/10.1309/0B06-Y93E-GE6T-Q36Y.
Takabatake N, Arao T, Sata M, et al. Involvement of pulmonary endothelial cell injury in the pathogenesis of pulmonary fibrosis: clinical assessment by 123i-mibg lung scintigraphy. Eur J Nucl Med Mol Imaging. 2005;32:221–8. https://doi.org/10.1007/s00259-004-1663-1.
Patel RB, Kotha SR, Sherwani SI, et al. Pulmonary fibrosis inducer, bleomycin, causes redox-sensitive activation of phospholipase d and cytotoxicity through formation of bioactive lipid signal mediator, phosphatidic acid, in lung microvascular endothelial cells. Int J Toxicol. 2011;30:69–90. https://doi.org/10.1177/1091581810388850.
Article CAS PubMed Google Scholar
Wouters E, Franssen FM. Chronic obstructive pulmonary disease: shifting the paradigm to the vasculature. Am J Respir Crit Care Med. 2019;199:258–9. https://doi.org/10.1164/rccm.201808-1542ED.
Article CAS PubMed Google Scholar
Gong J, Zhao H, Liu T, et al. Cigarette smoke reduces fatty acid catabolism, leading to apoptosis in lung endothelial cells: implication for pathogenesis of copd. Front Pharmacol. 2019;10:941. https://doi.org/10.3389/fphar.2019.00941.
Article CAS PubMed PubMed Central Google Scholar
de Jesus PV, Yuan K, Lyuksyutova MA, et al. Whole-exome sequencing reveals topbp1 as a novel gene in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014;189:1260–72. https://doi.org/10.1164/rccm.201310-1749OC.
Yang J, Nies MK, Fu Z, et al. Hepatoma-derived growth factor predicts disease severity and survival in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2016;194:1264–72. https://doi.org/10.1164/rccm.201512-2498OC.
Article CAS PubMed PubMed Central Google Scholar
Bauer PM, Bauer EM, Rogers NM, et al. Activated cd47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovasc Res. 2012;93:682–93. https://doi.org/10.1093/cvr/cvr356.
Article CAS PubMed PubMed Central Google Scholar
Scott TE, Qin CX, Drummond GR, Hobbs AJ, Kemp-Harper BK. Innovative anti-inflammatory and pro-resolving strategies for pulmonary hypertension: high blood pressure research council of Australia award 2019. Hypertension. 2021;78:1168–84. https://doi.org/10.1161/HYPERTENSIONAHA.120.14525.
留言 (0)