Advances in Pharmacology and Pharmacy Vol. 12(3), pp. 238 - 247
DOI: 10.13189/app.2024.120308
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Madhavi M N 1,*, Shiva Kumar G 2
1 Hi-Tech College of Pharmacy, Chandrapur, Maharashtra, India
2 GITAM School of Pharmacy, GITAM Deemed to be University, Hyderabad-502329, Telangana, India

ABSTRACT

In the present study, Iguratimod-loaded Cyclodextrin Nanosponges and carboxy methyl tamarind gum interpenetrating polymer networks (IPNs) based tablets were prepared to improve bio-pharmaceutical properties. By varying the concentration of carboxymethyl tamarind gum and glutaraldehyde as cross-linker, Iguratimod-loaded IPNs of formulations (T1-T5) were prepared by freeze-drying, characterized for FTIR, DSC, and XRD and evaluated for % drug loading, equilibrium swelling. Drug-loaded IPN tablets were prepared using Avicel PH-102 and performed in-vitro and in-vivo evaluation studies. The drug load in the IPNs varied between 61.43% and 66.57%, and swelling in the 0.1N HCl presence was significantly less than in the pH 6.8 phosphate buffer. Research employing XRD, DSC, and FTIR confirmed the formation of a molecular complex between Iguratimod and IPNs. The hardness, thickness, mean weight, friability, and average percentage drug content for Iguratimod-loaded IPN tablets were all within limits. Sustain release of drug was observed with IPN tablets in an In-vitro drug release study. In-vivo studies in rabbits estimated various pharmacokinetic constraints AUC0-∞, AUC0-t, Cmax, Tmax, and MRT. The AUC0-∞, t1/2, and MRT values of optimized formulations were pointedly more than those with pure drug and commercial tablets. Thus, related to the pure drug and the marketed product, the study's findings showed increased bioavailability and controlled release of Iguratimod from the optimized IPN tablet formulation.

KEYWORDS
Iguratimod, Carboxy Methyl Tamarind Gum, Interpenetrating Polymer Networks, Cyclodextrin-Nanosponges, IPN Tablets

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Madhavi M N , Shiva Kumar G , "Preparation and Characterization of Iguratimod Oral Formulation Using IPNs of Carboxymethyl Tamarind Seed Gum and Cyclodextrin Nanosponges," Advances in Pharmacology and Pharmacy, Vol. 12, No. 3, pp. 238 - 247, 2024. DOI: 10.13189/app.2024.120308.

(b). APA Format:
Madhavi M N , Shiva Kumar G (2024). Preparation and Characterization of Iguratimod Oral Formulation Using IPNs of Carboxymethyl Tamarind Seed Gum and Cyclodextrin Nanosponges. Advances in Pharmacology and Pharmacy, 12(3), 238 - 247. DOI: 10.13189/app.2024.120308.