Advances in Pharmacology and Pharmacy Vol. 12(3), pp. 186 - 198
DOI: 10.13189/app.2024.120304
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Suvarna P. Ingale 1,*, Anagha M. Joshi 2, Pramod L. Ingale 3
1 Department of Pharmacology, SCES's Indira College of Pharmacy, India
2 Department of Pharmaceutical Chemistry, SCES's Indira College of Pharmacy, India
3 Department of Pharmaceutical Chemistry, SGMSPM's Dyanvilas College of Pharmacy, India

ABSTRACT

Alzheimer's disease (AD) is a progressive neurodegenerative, multi-pathological and multifactorial disease affecting around 24 million people worldwide. There are few scientific reports on antioxidant and neuroprotective properties of Passiflora edulis. However, the molecular mechanism of Passiflora edulis leaves in management of AD has remained unexplored. Recently, network Pharmacology has emerged as a newer AI based approach to explore natural product actions and interactions with the multiple targets underlying diseases. Hence, in the present study, we attempted to explore molecular mechanism of Passiflora edulis leaves (PEL) in AD using novel AI based network pharmacology approach. The bioactives present in PEL were extracted from literature sources. Their protein targets were predicted using Swiss Target Prediction web tool. The proteins involved in pathogenesis of AD were retrieved from Therapeutic Target Database. We identified 30 bioactives of PEL modulating 44 potential PEL AD related targets. Of the 30 bioactives of PEL, β-Sitostenone exhibited the highest edge count with interaction with 13 target proteins of AD. Hence, β-Sitostenone has potential to be explored in management of AD. It was found that 44 potential targets of AD were associated with 17 signalling pathways including Alzheimer disease. ADORA2A was identified as the target protein with the highest number of interactions. Further, 14 bioactives have been identified to have AChE modulatory potential which can be explored in management of AD. In conclusion, we identified 27 bioactives of PEL as potential targets which altered majority of target proteins of AD mainly, ADORA2A, ACHE, CHRM3, APP, INSR, BACE1 and MAPT involved in pathogenesis of AD.

KEYWORDS
Network Pharmacology, Passiflora edulis, Alzheimer's Disease, Cytoscape, String

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Suvarna P. Ingale , Anagha M. Joshi , Pramod L. Ingale , "Network Pharmacology-Based Evaluation of Therapeutic Potential of Passiflora edulis Leaves in Alzheimer's Disease," Advances in Pharmacology and Pharmacy, Vol. 12, No. 3, pp. 186 - 198, 2024. DOI: 10.13189/app.2024.120304.

(b). APA Format:
Suvarna P. Ingale , Anagha M. Joshi , Pramod L. Ingale (2024). Network Pharmacology-Based Evaluation of Therapeutic Potential of Passiflora edulis Leaves in Alzheimer's Disease. Advances in Pharmacology and Pharmacy, 12(3), 186 - 198. DOI: 10.13189/app.2024.120304.