Advances in Pharmacology and Pharmacy Vol. 12(3), pp. 199 - 215
DOI: 10.13189/app.2024.120305
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Rakesh Mishra *, Sagar Dhadwad , Bhawana Sonawane , Chinmay Mali , Patodi Nidhi
Department of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, India

ABSTRACT

Quercetin, a remarkable flavonoid known for its extensive pharmacological benefits, faces challenges in its clinical utilization due to issues related to solubility, permeability, and a relatively shorter biological half-life. The study aims to formulate and optimize quercetin nanosuspension to improve bioavailability and to sustain its release. Quercetin nanosuspension is prepared through the precipitation-ultrasonication technique. Gelucire 43/01 and Compritol 888 ATO have been evaluated as lipid polymer stabilizers. The effect of the drug: polymer ratio and probe sonication time were studied and optimized. The optimum formulation of quercetin nanosuspension formulation was also further lyophilized to enhance its stability. The particle size, and entrapment efficiency of prepared batches ranged from 101 ±2.4 to 777 ±1.4nm and 73.65 ±1.61 to 85.89 ±1.56 % respectively. The optimized batch demonstrated a 6-fold improvement in solubility compared to quercetin with 90.45 ±0.84% drug release in 6 h. The results of Ex-vivo absorption studies performed by everted sac technique using rat intestine indicated 87.72+±1.53 % permeation of quercetin from the optimized formulation in 6 h compared to 15.39 ±1.27 % of pure drug. The outcome of the current study indicated that quercetin loaded lyophilized nanosuspension formulation with improved stability could provide a promising approach to enhance its overall bioavailability for its multifarious clinical use.

KEYWORDS
Quercetin, Nanosuspension, Precipitation-Ultrasonication, Solubility, Permeation

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Rakesh Mishra , Sagar Dhadwad , Bhawana Sonawane , Chinmay Mali , Patodi Nidhi , "Design and Characterization of Lipid Based Freeze Dried Quercetin Nanosuspension with Improved Bioavailability," Advances in Pharmacology and Pharmacy, Vol. 12, No. 3, pp. 199 - 215, 2024. DOI: 10.13189/app.2024.120305.

(b). APA Format:
Rakesh Mishra , Sagar Dhadwad , Bhawana Sonawane , Chinmay Mali , Patodi Nidhi (2024). Design and Characterization of Lipid Based Freeze Dried Quercetin Nanosuspension with Improved Bioavailability. Advances in Pharmacology and Pharmacy, 12(3), 199 - 215. DOI: 10.13189/app.2024.120305.