Advances in Pharmacology and Pharmacy Vol. 12(3), pp. 177 - 185
DOI: 10.13189/app.2024.120303
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Rohit Jaysing Bhor 1,*, Nirmal Sujata Eknath 1, Somnath Suryabhan Gholap 2, Santosh Bhausaheb Dighe 3
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, India
2 Department of Chemistry, Padmashri Vikhe Patil College of Arts, Science and Commerce, Pravaranagar, India
3 Department of Pharmacology, Pravara Rural College of Pharmacy, India

ABSTRACT

Introduction: Benzimidazole is a heterocyclic hydrocarbon having unique basic structural characteristics in their molecular structure. By treating 5 mL of an organized 20% aqueous extract of Acacia concinna pod in a 250 mL round-bottom flask, a variety of new 1-benzyl-2-phenyl-1H-benzo[d]imidazole (SN1) and its derivatives were created. O-phenylenediamine (1 mmol) was added to the extract above while stirring. After entire addition of o-phenylenediamine, aldehyde (2 mmol) became introduced with continuous stirring at room temperature. Methods: The structure confirmations of synthesized compounds were done by FTIR, NMR spectroscopy and MS. The title compounds and its derivatives were investigated for in vivo anticonvulsant properties by using Wistar Rats. It was done by Strychnine Induced Convulsion Method. Phenytoin is standard drugs for this activity. Structural activity relationship studies reveal that compounds possessing an electron-withdrawing group exhibit better activity than the compounds containing electron-donating groups. Results: Based on the results obtained, when compared to common medicines like Phenytoin, the compounds 4-(1-(4-hydroxy-3-methoxybenzyl)-1H-benzo[d]imidazol-2-yl)-2-methoxyphenol (SN3), 4-(1-(4-hydroxybenzyl)-1H-benzo[d]imidazol-2-yl) phenol (SN4), 1-(4-nitrobenzyl)-2-(4-nitrophenyl)-1H-benzo[d]imidazole (SN5), 1-(2-chlorobenzyl)-2-(2-chlorophenyl)-1H-benzo[d]imidazole (SN6), 1-(3-nitrobenzyl)-2-(3-nitrophenyl)-1H-benzo[d]imidazole (SN7), 1-(4-Hydroxy-3-methoxybenzyl)-2-(4-hydroxy-3-methoxyphenyl)-1H-1, 3-benzimidazole (SN8) give strong anti convulsant effects against phenytoin drug. Conclusion: The title compounds and its derivatives were investigated for anti convulsant Activity. Structural activity relationship studies told that compounds containing benzimidazole derivatives possessing an electron-withdrawing group exhibit better activity than the compounds containing electron-donating groups. The results of the preliminary anti convulsant testing results of the prepared compounds were shown in Table 3. The synthesized compounds were screened for their anti convulsant activity and 1-(4-nitrobenzyl)-2-(4-nitrophenyl)-1H-benzo[d]imidazole (SN5), 1-(2-chlorobenzyl)-2-(2-chlorophenyl)-1H-benzo[d]imidazole (SN6), 1-(3-nitrobenzyl)-2-(3-nitrophenyl)-1H-benzo[d]imidazole (SN7) give strong anti convulsant effects against phenytoin drug.

KEYWORDS
Benzimidazole, 3- Nitro Benzaldehyde, 4-Cholro Benzaldehyde, 4-Methyl Benzaldehyde, 3,4-Dimethyl Benzaldehyde, Anti Convulsant Activity, Phenytoin

Cite This Paper in IEEE or APA Citation Styles
(a). IEEE Format:
[1] Rohit Jaysing Bhor , Nirmal Sujata Eknath , Somnath Suryabhan Gholap , Santosh Bhausaheb Dighe , "Synthesis, Characterization and In-Vivo Anti Convulsant Activity of "Benzimidazole and Its Derivatives by Using Aqueous Extract of Acacia Concinna Pods (20% w/v)"," Advances in Pharmacology and Pharmacy, Vol. 12, No. 3, pp. 177 - 185, 2024. DOI: 10.13189/app.2024.120303.

(b). APA Format:
Rohit Jaysing Bhor , Nirmal Sujata Eknath , Somnath Suryabhan Gholap , Santosh Bhausaheb Dighe (2024). Synthesis, Characterization and In-Vivo Anti Convulsant Activity of "Benzimidazole and Its Derivatives by Using Aqueous Extract of Acacia Concinna Pods (20% w/v)". Advances in Pharmacology and Pharmacy, 12(3), 177 - 185. DOI: 10.13189/app.2024.120303.