The effects of doxapram and its potential interactions with K2P channels in experimental model preparations

Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE et al (2000) The genome sequence of Drosophila melanogaster. Science 287(5461):2185–2195. https://doi.org/10.1126/science.287.5461.2185

Article  PubMed  Google Scholar 

Baierlein B, Thurow AL, Atwood HL, Cooper RL (2011) Membrane potentials, synaptic responses, neuronal circuitry, neuromodulation and muscle histology using the crayfish: student laboratory exercises. J Vis Exp 47:e2322. https://doi.org/10.3791/2322

Article  Google Scholar 

Baxter AD (1976) Side effects of doxapram infusion. Eur J Intensive Care Med 2(2):87–88. https://doi.org/10.1007/BF01886121

Article  CAS  PubMed  Google Scholar 

Brock KE, Cooper RL (2023) The effects of doxapram blocking the response of Gram-negative bacterial toxin (LPS) at glutamatergic synapses. BIOLOGY 12(8):1046. https://doi.org/10.3390/biology12081046

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buckingham SD, Kidd JF, Law RJ, Franks CJ, Sattelle DB (2005) Structure and function of two-pore-domain K + channels: contributions from genetic model organisms. Trends Pharmacol Sci 26:361–367. https://doi.org/10.1016/j.tips.2005.05.003

Article  CAS  PubMed  Google Scholar 

Budnik V, Koh YH, Guan B, Hartmann B, Hough C, Woods D, Gorczyca M (1996) Regulation of synapse structure and function by the Drosophila tumor suppressor gene dlg. Neuron 17(4):627–640. https://doi.org/10.1016/s0896-6273(00)80196-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cooper AS, Cooper RL (2009) Historical view and physiology demonstration at the nmj of the crayfish opener muscle. J Vis Exp 33:e1595. https://doi.org/10.3791/1595

Article  Google Scholar 

Cooper RL, Krall RM (2022) Hyperpolarization induced by lipopolysaccharides but not by chloroform is inhibited by doxapram, an inhibitor of two-p-domain k+ channel (K2P). Int J Mol Sci 23:15787. https://doi.org/10.3390/ijms232415787

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cooper RL, McNabb M, Nadolski J (2019) The effects of a bacterial endotoxin LPS on synaptic transmission at the neuromuscular junction. Heliyon 5:e01430. https://doi.org/10.1016/j.heliyon.2019.e01430

Article  PubMed  PubMed Central  Google Scholar 

Cotten JF, Keshavaprasad B, Laster MJ, Eger EI 2, Yost CS (2006) The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg 102(3):779–785. https://doi.org/10.1213/01.ane.0000194289.34345.63

Article  CAS  PubMed  Google Scholar 

Crider ME, Cooper RL (2000) Differential facilitation of high- and low output nerve terminals from a single motor neuron. J Appl Physiol 88:987–996. https://doi.org/10.1152/jappl.2000.88.3.987

Article  CAS  PubMed  Google Scholar 

Cunningham KP, MacIntyre DE, Mathie A, Veale EL (2020) Effects of the ventilatory stimulant, doxapram on human TASK-3 (KCNK9, K2P9.1) channels and TASK-1 (KCNK3, K2P3.1) channels. Acta Physiol (Oxf) 228(2):e13361. https://doi.org/10.1111/apha.13361

Article  CAS  PubMed  Google Scholar 

de Castro C, Titlow J, Majeed ZR, Cooper RL (2014) Analysis of various physiological salines for heart rate, CNS function, and synaptic transmission at neuromuscular junctions in Drosophila melanogaster larvae. J Comp Physiol A 200(1):83–92. https://doi.org/10.1007/s00359-013-0864-0

Article  CAS  Google Scholar 

Elliott ER, Taul AC, Abul-Khoudoud MO, Hensley N, Cooper RL (2023) Effect of doxapram, bacterial endotoxin and pH on heart rate: Larval Drosophila model. Appl Biosci 2:406–420. https://doi.org/10.3390/applbiosci2030026

Article  Google Scholar 

Enyedi P, Czirják G (2010) Molecular background of leak K+ currents: two-pore domain potassium channels. Physiol Rev 90:559–605. https://doi.org/10.1152/physrev.00029.2009

Article  CAS  PubMed  Google Scholar 

Fathi M, Massoudi N, Nooraee N, Beheshti Monfared R (2020) The effects of doxapram on time to tracheal extubation and early recovery in young morbidly obese patients scheduled for bariatric surgery: a randomised controlled trial. Eur J Anaesthesiol 37(6):457–465. https://doi.org/10.1097/EJA.0000000000001144

Article  CAS  PubMed  Google Scholar 

Feliciangeli S, Chatelain FC, Bichet D, Lesage F (2015) The family of K2P channels: salient structural and functional properties. J Physiol 593(12):2587–2603. https://doi.org/10.1113/jphysiol.2014.287268

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flint RB, Simons SHP, Andriessen P, Liem KD, Degraeuwe PLJ, Reiss IKM et al (2021) The bioavailability and maturing clearance of doxapram in preterm infants. Pediatr Res 89(5):1268–1277. https://doi.org/10.1038/s41390-020-1037-9

Article  CAS  PubMed  Google Scholar 

Goldman DE (1943) Potential, impedance, and rectification in membranes. J Gen Physiol 27:37–60. https://doi.org/10.1085/jgp.27.1.37

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldstein SA (2011) K2P potassium channels, mysterious and paradoxically exciting. Sci Signal 4(184):pe35. https://doi.org/10.1126/scisignal.2002225

Article  CAS  PubMed  Google Scholar 

Goldstein SA, Price LA, Rosenthal DN, Pausch MH (1996) ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 93(23):13256–13261. https://doi.org/10.1073/pnas.93.23.13256. Erratum in: Proc Natl Acad Sci U S A 1999;96(1):318

Goldstein SA, Wang KW, Ilan N, Pausch MH (1998) Sequence and function of the two P domain potassium channels: implications of an emerging superfamily. J Mol Med (Berl) 76:13–20. https://doi.org/10.1007/s001090050186

Article  CAS  PubMed  Google Scholar 

Harrison DA, Cooper RL (2023) Characterization of development, behavior and neuromuscular physiology in the phorid fly, Megaselia scalaris. Comp Biochem Physiol A 136(2):427–439. https://doi.org/10.1016/s1095-6433(03)00200-9

Article  Google Scholar 

He P, Southard RC, Whiteheart SW, Cooper RL (1999) Role of α-SNAP in promoting efficient neurotransmission at the crayfish neuromuscular junction. J Neurophysiol 82:3406–3416. https://doi.org/10.1152/jn.1999.82.6.3406

Article  CAS  PubMed  Google Scholar 

Heckmann M, Dudel J (1997) Desensitization and resensitization kinetics of glutamate receptor channels from Drosophila larval muscle. Biophys J 72(5):2160–2169. https://doi.org/10.1016/S0006-3495(97)78859-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hille B (1992) Ionic channels of excitable membranes, 2nd edn. Sinauer Assoc, Sunderland, Mass, USA

Google Scholar 

Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond) 117:500–544. https://doi.org/10.1007/BF02459568

Article  CAS  PubMed  Google Scholar 

Hodgkin AL, Katz B (1949) The effect of sodium ions on the electrical activity of the giant axon of the squid. J Physiol 108:37–77. https://doi.org/10.1113/jphysiol.1949.sp004310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hodgkin AL, Huxley AF, Katz B (1952) Measurement of current-voltage relations in the membrane of the giant axon of Loligo. J Physiol (Lond) 116:424–448. https://doi.org/10.1113/jphysiol.1952.sp004716

Article  CAS  PubMed  Google Scholar 

Ikeda K, Ozawa S, Hagiwara S (1976) Synaptic transmission reversibly conditioned by single-gene mutation in Drosophila melanogaster. Nature 259:489–491. https://doi.org/10.1038/259489a0

Article  CAS  PubMed  Google Scholar 

ISBN 9780199847839

Ison BJ, Abul-Khoudoud MO, Ahmed SM, Alhamdani AW, Ashley C, Bidros PC et al (2022) The effect of Doxapram on proprioceptive neurons: invertebrate model. NeuroSci 3:566–588. https://doi.org/10.3390/neurosci3040041

Article  Google Scholar 

Kamuene JM, Xu Y, Plant LD (2021) The pharmacology of two-pore domain potassium channels. Handb Exp Pharmacol 267:417–443. https://doi.org/10.1007/164_2021_462

Article  CAS  PubMed  Google Scholar 

Karklus AA, Sladky KK, Johnson SM (2021) Respiratory and antinociceptive effects of dexmedetomidine and doxapram in ball pythons (Python regius). Am J Vet Res 82(1):11–21. https://doi.org/10.2460/ajvr.82.1.11

Article  CAS  PubMed  Google Scholar 

Ketchum KA, Joiner WJ, Sellers AJ, Kaczmarek LK, Goldstein SA (1995) A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature 376(6542):690–695. https://doi.org/10.1038/376690a0

Article  CAS  PubMed  Google Scholar 

Kim D (2005) Physiology and pharmacology of two-pore domain potassium channels. Curr Pharm Des 11(21):2717–2736. https://doi.org/10.2174/1381612054546824

Article  CAS  PubMed  Google Scholar 

Kuang Q, Purhonen P, Hebert H (2015) Structure of potassium channels. Cell Mol Life Sci 72(19):3677–3693. https://doi.org/10.1007/s00018-015-1948-5

留言 (0)

沒有登入
gif