aDobney Hypertension Centre, Medical School - Royal Perth Hospital Unit, The University of Western Australia, Perth, Western Australia

bThe George Institute for Global Health, University of New South Wales

cWestmead Applied Research Centre, University of Sydney

dDepartment of Cardiology, Westmead Hospital, Sydney, New South Wales

eDepartment of Cardiology, Royal Perth Hospital

fSchool of Medicine, The University of Western Australia, Perth, Western Australia

gMenzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania

hSchool of Public Health & Preventive Medicine Monash University, School of Population Health, Curtin University, Perth, Western Australia

iCastle Hill Medical Centre Sydney

jSchool of Medicine, Western Sydney University, Sydney, New South Wales

kSir Charles Gairdner Hospital, Perth, Western Australia

lNeurovascular Hypertension & Kidney Disease Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

Correspondence to Prof. Markus P. Schlaich, Dobney Chair in Clinical Research, Medical School - Royal Perth Hospital Unit, The University of Western Australia, Level 3, MRF Building, Rear 50 Murray St, Perth, WA 6000, Australia. Tel: +61 8 9224 0334; fax: +61 8 9224 0374; e-mail: [email protected]

Abbreviations: ABPM, Ambulatory BP monitoring; BP, Blood pressure; GLMM, Generalized linear mixed-effects model; LMM, Linear Mixed effects regression Models; MAP, Mean arterial pressure; QUARTET, Quadruple combination of quarter doses of blood pressure medicines vs. standard dose monotherapy in patients with hypertension

Received 14 November, 2023

Revised 22 December, 2023

Accepted 15 January, 2024

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