Tschumperlin DJ, Liu F, Tager AM. Biomechanical regulation of mesenchymal cell function. Curr Opin Rheumatol. 2013;25:92–100.

Article  PubMed  PubMed Central  Google Scholar 

Urbanczyk M, Layland SL, Schenke-Layland K. The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues. Matrix Biol. 2020;85–86:1–14.

Article  PubMed  Google Scholar 

Lee HN, Choi YY, Kim JW, Lee YS, Choi JW, Kang T, et al. Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip. Nano Converg. 2021;8:35

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park SM, Eom S, Hong H, Yoon J, Lee SJ, Kim BC, et al. Reconstruction of in vivo-like in vitro model: enabling technologies of microfluidic systems for dynamic biochemical/mechanical stimuli. Microelectron Eng. 2019;203:6–24

Article  Google Scholar 

Tehrani-Rokh M, Kouzani AZ, Kanwar JR. Gradient generating microfluidic devices for cell cultivation. Procedia Eng. 2012;29:1740–4.

Abadie T, Sella C, Perrodin P, Thouin L. Electrochemical generation and detection of transient concentration gradients in microfluidic channels. Theoretical and experimental investigations. Front Chem. 2019;7:704.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang S, Hu H, Kung H, Zou R, Dai Y, Hu Y, et al. Organoids: The current status and biomedical applications. MedComm (2020). 2023;4:e274.

Google Scholar 

Kim J, Koo BK, Knoblich JA. Human organoids: model systems for human biology and medicine. Nat Rev Mol Cell Biol. 2020;21:571–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shankaran A, Prasad K, Chaudhari S, Brand A, Satyamoorthy K. Advances in development and application of human organoids. 3 Biotech. 2021;11:257.

Article  PubMed  PubMed Central  Google Scholar 

Suarez-Martinez E, Suazo-Sanchez I, Celis-Romero M, Carnero A. 3D and organoid culture in research: physiology, hereditary genetic diseases and cancer. Cell Biosci. 2022;12:39

Karimi A, Aga M, Khan T, D'costa SD, Cardenas-Riumallo S, Zelenitz M, et al. Dynamic traction force in trabecular meshwork cells: a 2D culture model for normal and glaucomatous states. Acta Biomater. 2024;175:138–56

Article  PubMed  Google Scholar 

Li H, Bagué T, Kirschner A, Strat AN, Roberts H, Weisenthal RW, et al. A tissue-engineered human trabecular meshwork hydrogel for advanced glaucoma disease modeling. Exp Eye Res. 2021;205:108472.

Article  CAS  PubMed  Google Scholar 

Crouch DJ, Sheridan CM, Behnsen JG, D'Sa RA, Bosworth LA. Cryo-electrospinning generates highly porous fiber scaffolds which improves trabecular meshwork cell infiltration. J Funct Biomater. 2023;14:490.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Włodarczyk-Biegun MK, Villiou M, Koch M, Muth C, Wang P, Ott J, et al. Melt electrowriting of graded porous scaffolds to mimic the matrix structure of the human trabecular meshwork. ACS Biomater Sci Eng. 2022;8:3899–911.

Article  PubMed  PubMed Central  Google Scholar 

Tian YI, Zhang X, Torrejon K, Danias J, Du Y, Xie Y. A biomimetic, stem cell-derived in vitro ocular outflow model. Adv Biosyst. 2020;4:e2000004.

Article  PubMed  PubMed Central  Google Scholar 

Adhikari B, Osmond MJ, Pantcheva MB, Krebs MD. Glycosaminoglycans influence extracellular matrix of human trabecular meshwork cells cultured on 3D scaffolds. ACS Biomater Sci Eng. 2022;8:5221–32.

Article  CAS  PubMed  Google Scholar 

Ota C, Ida Y, Ohguro H, Hikage F. ROCK inhibitors beneficially alter the spatial configuration of TGFβ2-treated 3D organoids from a human trabecular meshwork (HTM). Sci Rep. 2020;10:20292

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121:2081–90.

Article  PubMed  Google Scholar 

Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004;363:1711–20.

Article  Google Scholar 

Choi HG, Lee MJ, Lee SM. Mortality and causes of death in a population with blindness in Korea: a longitudinal follow-up study using a national sample cohort. Sci Rep. 2020;10:4891.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SY, Lee H, Lee JS, Han SA, Kim YJ, Kim JY, et al. Association between glaucoma surgery and all-cause and cause-specific mortality among elderly patients with glaucoma: a nationwide population-based cohort study. Sci Rep. 2021;11:17055.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Quigley HA. Glaucoma. Lancet. 2011;377:1367–77.

Article  Google Scholar 

Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M. Reduction of intraocular pressure and glaucoma progression: results from the early manifest glaucoma trial. Arch Ophthalmol. 2002;120:1268–79.

Article  PubMed  Google Scholar 

Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311:1901–11. .

Article  PubMed  PubMed Central  Google Scholar 

Bill A, Phillips CI. Uveoscleral drainage of aqueous humour in human eyes. Exp Eye Res. 1971;12:275–81.

Article  CAS  PubMed  Google Scholar 

Bill A. Some aspects of aqueous humour drainage. Eye. 1993;7:14–9.

Article  PubMed  Google Scholar 

Vranka JA, Kelley MJ, Acott TS, Keller KE. Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma. Exp Eye Res. 2015;133:112–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cela D, Brignole-Baudouin F, Labbé A, Baudouin C. The trabecular meshwork in glaucoma: an inflammatory trabeculopathy? J Fr Ophtalmol. 2021;44:e497–517.

Article  CAS  PubMed  Google Scholar 

Marshall GE, Konstas AG, Lee WR. Immunogold localization of type IV collagen and laminin in the aging human outflow system. Exp Eye Res. 1990;51:691–9.

Article  CAS  PubMed  Google Scholar 

Marshall GE, Konstas AGP, Lee WR. Immunogold ultrastructural localization of collagens in the aged human outflow system. Ophthalmology. 1991;98:692–700.

Article  CAS  PubMed  Google Scholar 

Dautriche CN, Xie Y, Sharfstein ST. Walking through trabecular meshwork biology: toward engineering design of outflow physiology. Biotechnol Adv. 2014;32:971–83.

Article  PubMed  Google Scholar 

Costagliola C, dell'Omo R, Agnifili L, Bartollino S, Fea AM, Uva MG, et al. How many aqueous humor outflow pathways are there? Surv Ophthalmol. 2020;65:144–70.

Article  PubMed  Google Scholar 

Grant WM. Further studies on facility of flow through the trabecular meshwork. AMA Arch Ophthalmol. 1958;60:523–33.

Article  CAS  PubMed  Google Scholar 

Overby DR, Stamer WD, Johnson M. The changing paradigm of outflow resistance generation: towards synergistic models of the JCT and inner wall endothelium. Exp Eye Res. 2009;88:656–70.

Article  CAS  PubMed  Google Scholar 

Acott TS, Kelley MJ, Keller KE, Vranka JA, Abu-Hassan DW, Li X, et al. Intraocular pressure homeostasis: maintaining balance in a high-pressure environment. J Ocul Pharmacol Ther. 2014;30:94–101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stamer WD, Clark AF. The many faces of the trabecular meshwork cell. Exp Eye Res. 2017;158:112–23.

Article  CAS  PubMed  Google Scholar 

Polansky JR, Weinreb RN, Baxter JD, Alvarado J. Human trabecular cells. I. Establishment in tissue culture and growth characteristics. Invest Ophthalmol Vis Sci. 1979;18:1043–9.

CAS  Google Scholar 

Grierson I, Rahi AH. Microfilaments in the cells of the human trabecular meshwork. Br J Ophthalmol. 1979;63:3. .

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shifera AS, Trivedi S, Chau P, Bonnemaison LH, Iguchi R, Alvarado JA. Constitutive secretion of chemokines by cultured human trabecular meshwork cells. Exp Eye Res. 2010;91:42–7.

Article  CAS  PubMed  Google Scholar 

Epstein DL, Freddo TF, Anderson PJ, Patterson MM, Bassett-Chu S. Experimental obstruction to aqueous outflow by pigment particles in living monkeys. Invest Ophthalmol Vis Sci. 1986;27:387–95.

CAS  PubMed  Google Scholar 

Johnson DH, Richardson TM, Epstein DL. Trabecular meshwork recovery after phagocytic challenge. Curr Eye Res. 1989;8:1121–30.